Dose-dependent differences in short ultrasonic vocalizations emitted by rats during cocaine self-administration.

abstract：OBJECTIVES:Ayahuasca is a traditional South American psychoactive beverage and the central sacrament of Brazilian-based religious groups, with followers in Europe and the United States. The tea contains the psychedelic indole N,N-dimethyltryptamine (DMT) and beta-carboline alkaloids with monoamine oxidase-inhibiting pr...

journal_title：Psychopharmacology

authors： Barbanoj MJ,Riba J,Clos S,Giménez S,Grasa E,Romero S

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:Batteries of tests that are thought to measure different aspects of anxiety-related behaviour are used to characterise mice after genetic or pharmacological manipulation. However, because of the potentially confounding effects of repeated testing and natural intra-individual variations in behaviour over time,...

journal_title：Psychopharmacology

authors： Fraser LM,Brown RE,Hussin A,Fontana M,Whittaker A,O'Leary TP,Lederle L,Holmes A,Ramos A

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...

journal_title：Psychopharmacology

authors： Concas A,Sogliano C,Porcu P,Marra C,Brundu A,Biggio G

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Convergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between the amygdala and the prefrontal cortex (PFC), alcohol's effects are likely to extend beyond regional ch...

journal_title：Psychopharmacology

authors： Gorka SM,Fitzgerald DA,King AC,Phan KL

更新日期：2013-09-01 00:00:00

abstract：:The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by th...

journal_title：Psychopharmacology

authors： Neill JC,Cooper SJ

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Beneficial effects of nicotine on cognitive processes including attention have potential therapeutic uses and have been proposed as incentives for tobacco smoking. OBJECTIVES:To establish task conditions under which the effects of nicotine on attention are obtained reliably and to characterise such effects f...

journal_title：Psychopharmacology

authors： Hahn B,Shoaib M,Stolerman IP

更新日期：2002-07-01 00:00:00

abstract：:A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppres...

journal_title：Psychopharmacology

authors： Miczek KA,Weerts EM,Vivian JA,Barros HM

更新日期：1995-09-01 00:00:00

abstract：:The purpose of this study was to investigate the developmental differences in seizure susceptibility in mice and the roles of the histaminergic neuron system in inhibition of convulsions in development. First, we studied developmental differences in electrically-induced seizures. Since the 14-day-old mice showed a dif...

journal_title：Psychopharmacology

authors： Yokoyama H,Onodera K,Iinuma K,Watanabe T

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. OBJECTIVES:This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administer...

journal_title：Psychopharmacology

authors： Griffiths RR,Richards WA,McCann U,Jesse R

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. OBJECTIVES:To determine the human cytochromes P450 mediating the metabolism of nefazodone, and the inhibitory...

journal_title：Psychopharmacology

authors： von Moltke LL,Greenblatt DJ,Granda BW,Grassi JM,Schmider J,Harmatz JS,Shader RI

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...

journal_title：Psychopharmacology

authors： Ciccocioppo R,Biondini M,Antonelli L,Wichmann J,Jenck F,Massi M

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:Early onset of heroin use during adolescence might increase chances of later drug addiction. Prior work from our laboratory suggests, however, that adolescent male rats are actually less sensitive than adults to some enduring effects of heroin self-administration. In the present study, we tested two likely c...

journal_title：Psychopharmacology

authors： Doherty JM,Frantz KJ

更新日期：2013-02-01 00:00:00

abstract：:The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...

journal_title：Psychopharmacology

authors： Ogura C,Nakazawa K,Majima K,Nakamura K,Ueda H,Umezawa Y,Wardell WM

更新日期：1980-01-01 00:00:00

abstract：:Established social groups of talapoin monkeys show rank-related differences in aggressive, social and sexual behaviours and visual monitoring, as well as in endocrine and monoamine profiles. Here we describe the effects on these variables of an "anxiogenic drug", beta-carboline carboxylic acid ethyl ester (beta-CCE), ...

journal_title：Psychopharmacology

authors： Vellucci SV,Herbert J,Keverne EB

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Salvinorin A, the primary psychoactive derivative of the hallucinogenic herb Salvia divinorum, is a potent and highly selective kappa-opioid receptor (KOR) agonist. Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects. OBJECTIVES:This study represents a syst...

journal_title：Psychopharmacology

authors： Walentiny DM,Vann RE,Warner JA,King LS,Seltzman HH,Navarro HA,Twine CE Jr,Thomas BF,Gilliam AF,Gilmour BP,Carroll FI,Wiley JL

更新日期：2010-06-01 00:00:00

abstract：:In the present study we have investigated the effects of diazepam (DZP) (10 mg/kg) treatment of rat dams during different periods of gestation or during lactation on the development and behavior of their offspring. The results show that DZP exposure during different phases of early development has differing effects on...

journal_title：Psychopharmacology

authors： Frieder B,Epstein S,Grimm VE

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:The intake of psychostimulant drugs may induce cognitive dysfunction and negative affective-like states, and is associated with increased activity of stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates neuroendocrine, behavioural and autonomic responses to stressors, and might ...

journal_title：Psychopharmacology

authors： Morisot N,Millan MJ,Contarino A

更新日期：2014-10-01 00:00:00

abstract：:The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and nighttime experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of met...

journal_title：Psychopharmacology

authors： Risch C,Kripke D,Janowsky D

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth. OBJECTIVES:This review describes the existing published and unpublished literat...

journal_title：Psychopharmacology

authors： Boylan K,Romero S,Birmaher B

更新日期：2007-03-01 00:00:00

abstract：RATIONALE:Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. OBJECTIVES:The present experiments evaluated the influence of opioid re...

journal_title：Psychopharmacology

authors： Vivian JA,Miczek KA

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...

journal_title：Psychopharmacology

authors： Sukhtankar DD,Lee H,Rice KC,Ko MC

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...

journal_title：Psychopharmacology

authors： Cui X,Lefevre E,Turner KM,Coelho CM,Alexander S,Burne TH,Eyles DW

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...

journal_title：Psychopharmacology

authors： Dallery J,Raiff BR

更新日期：2007-03-01 00:00:00

abstract：:This study compared the efficacy of buprenorphine to methadone for decreasing cocaine use in patients with combined opioid and cocaine use. Participants (n = 51) were enrolled in a 26-week treatment program and randomly assigned to either buprenorphine or methadone. Dosing was double-blind and double-dummy. Patients w...

journal_title：Psychopharmacology

authors： Strain EC,Stitzer ML,Liebson IA,Bigelow GE

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a potent and selective serotonin neurotoxin whose use is growing among adolescents. Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence. OBJ...

journal_title：Psychopharmacology

authors： Jacobsen LK,Mencl WE,Pugh KR,Skudlarski P,Krystal JH

更新日期：2004-05-01 00:00:00

abstract：:Pretreatment of rats with hydantoin (75 mg/kg, PO, an anticonvulsant), trihexyphenidyl (10 mg/kg, SC, a muscarinic cholinergic antagonist), or piperonyl butoxide (500 mg/kg, PO, a metabolic inhibitor) had no effect on the whole blood or brain tissue levels of orally administered DDT (75 mg/kg) or its metabolites DDD a...

journal_title：Psychopharmacology

authors： Herr DW,Hong JS,Chen P,Tilson HA,Harry GJ

更新日期：1986-01-01 00:00:00

abstract：:Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...

journal_title：Psychopharmacology

authors： Caligiuri MP,Lohr JB,Rotrosen J,Adler L,Lavori P,Edson R,Tracy K

更新日期：1997-07-01 00:00:00

abstract：:There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days wit...

journal_title：Psychopharmacology

authors： Bjartmar L,Johansson IM,Marcusson J,Ross SB,Seckl JR,Olsson T

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...

journal_title：Psychopharmacology

authors： MacKenzie G,Maguire J

更新日期：2014-09-01 00:00:00

abstract：RATIONALE:Methamphetamine (METH) is a powerfully addictive stimulant associated with serious health conditions. Accumulating evidence suggests a role of oxidative stress in METH-induced behavioral abnormalities. Sulforaphane (SFN), found in cruciferous vegetables, is a potent antioxidant. It is of interest to determine...

journal_title：Psychopharmacology

authors： Chen H,Wu J,Zhang J,Fujita Y,Ishima T,Iyo M,Hashimoto K

更新日期：2012-07-01 00:00:00