Buprenorphine versus methadone in the treatment of opioid-dependent cocaine users.

Abstract:

:This study compared the efficacy of buprenorphine to methadone for decreasing cocaine use in patients with combined opioid and cocaine use. Participants (n = 51) were enrolled in a 26-week treatment program and randomly assigned to either buprenorphine or methadone. Dosing was double-blind and double-dummy. Patients were stabilized on either 8 mg sublingual buprenorphine or 50 mg oral methadone, with dose increases given in response to continued illicit cocaine use or opioid use through week 16 of treatment. Maximum doses possible were 16 mg buprenorphine and 90 mg methadone. Average doses achieved were 11.2 mg buprenorphine and 66.6 mg methadone; 49% of the patients received the maximum doses possible. Urine samples were collected three times per week, and there was no significant difference in the rate of cocaine positive urines for the intent-to-treat sample (69% for buprenorphine versus 63% for methadone). For patients who remained in treatment through the flexible dosing period (n = 28), there were significant decreases in cocaine positive urines over time (P < 0.01), but no significant differences between groups or group x time effects. Buprenorphine and methadone were equally effective on measures of treatment retention, urine results for opioids, and compliance with attendance and counseling. These results demonstrate no selective efficacy of either buprenorphine or methadone in attenuating cocaine use in this population, but do provide further support for the equivalent efficacy of buprenorphine and methadone in the treatment of opioid dependence.

journal_title

Psychopharmacology

authors

Strain EC,Stitzer ML,Liebson IA,Bigelow GE

doi

10.1007/BF02247469

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

401-6

issue

4

eissn

0033-3158

issn

1432-2072

journal_volume

116

pub_type

临床试验,杂志文章,随机对照试验
  • Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity.

    abstract:OBJECTIVES:The present study investigates the effects of injections of a specific N-methyl-D-aspartic acid (NMDA) antagonist 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phophonic acid (CPP) into the prefrontal cortex (PFC) on the extracellular concentrations of dopamine and acetylcholine in the nucleus accumbens (NAc) and...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-008-1288-3

    authors: Del Arco A,Segovia G,Mora F

    更新日期:2008-12-01 00:00:00

  • Antidepressants and human memory: an investigation of four drugs with different sedative and anticholinergic profiles.

    abstract::The effects on memory and psychomotor functions of four antidepressants which differ in sedative and anticholinergic properties were assessed. Amitriptyline (37.5, 70 mg), trazodone (100, 200 mg) viloxazine (100, 200 mg), protriptyline (10, 20 mg) or placebo were administered in a double blind, independent groups desi...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00172967

    authors: Curran HV,Sakulsriprong M,Lader M

    更新日期:1988-01-01 00:00:00

  • Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism.

    abstract::This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying intensities of a tactile stimulus and the magnitudes of the...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050820

    authors: Harvey JA,Welsh SE,Hood H,Romano AG

    更新日期:1999-01-01 00:00:00

  • The relationship between stereotypy and memory improvement produced by amphetamine.

    abstract::This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427774

    authors: Carr GD,White NM

    更新日期:1984-01-01 00:00:00

  • Correction to: Estimating the optimal dose of flupentixol decanoate in the maintenance treatment of schizophrenia-a systematic review of the literature.

    abstract::An error in Fig. 3 was introduced in the production process which the authors have asked to be rectified. Below is the correct figure. ...

    journal_title:Psychopharmacology

    pub_type: 已发布勘误

    doi:10.1007/s00213-019-05340-x

    authors: Bailey L,Taylor D

    更新日期:2019-11-01 00:00:00

  • Chronic exposure to cocaine is associated with persistent behavioral disturbances. A cross-sectional dimensional study in outpatients with multiple substance use disorders.

    abstract:RATIONALE:Behavioral disturbances (BD) are prevalent in patients with substance use disorders (SUD). OBJECTIVES:To test the hypothesis that chronic exposure to cocaine could favor the acquisition of BD that were not present in childhood. METHODS:We used child and adult ADHD self-report screening scales (WURS-25 and A...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05620-x

    authors: Vorspan F,de Witt P,Zerdazi EH,Karsinti E,Ksouda K,Icick R,Bellivier F,Marie N,Brousse G,Bloch V

    更新日期:2020-11-01 00:00:00

  • Blockade of the discriminative stimulus effects of cocaine in rhesus monkeys with the D1 dopamine antagonist SCH 23390.

    abstract::To investigate the role of D1 dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 mg/kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related in...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00181961

    authors: Kleven MS,Anthony EW,Goldberg LI,Woolverton WL

    更新日期:1988-01-01 00:00:00

  • Social stress is as effective as physical stress in reinstating morphine-induced place preference in mice.

    abstract:RATIONALE:Relapse to drug-seeking in abstinent heroin addicts and reinstatement in experimental animals are observed when exposed to drug-associated stimuli or cues, the drug itself, and stressful events. It has been shown that footshock-induced stress increases the rewarding effects of opiates, delays extinction, and ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0345-z

    authors: Ribeiro Do Couto B,Aguilar MA,Manzanedo C,Rodríguez-Arias M,Armario A,Miñarro J

    更新日期:2006-05-01 00:00:00

  • Specific oculomotor deficit after acute methadone. II. Smooth pursuit eye movements.

    abstract::Changes in smooth pursuit eye tracking of targets moving sinusoidally in horizontal and vertical planes before and after up to 10 mg oral methadone were measured electrooculographically in nontolerant nondependent humans. Methadone depressed the gain of horizontal tracking movements at most frequencies tested (0.2 - 1...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00431261

    authors: Rothenberg S,Schottenfeld S,Selkoe D,Gross K

    更新日期:1980-01-01 00:00:00

  • Effects of acute or chronic carbamazepine on experimentally-induced conflict in the rat.

    abstract::The effects of acutely or chronically administered carbamazepine were studied in rats submitted to the modified Geller-Seifter conflict test. Diazepam was used as a standard anxiolytic. The results showed an increase in punished response after carbamazepine, as observed with diazepam, leading to the suggestion of an a...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244411

    authors: Almeida RN,Leite JR

    更新日期:1990-01-01 00:00:00

  • A novel 2- and 3-choice touchscreen-based continuous trial-unique nonmatching-to-location task (cTUNL) sensitive to functional differences between dentate gyrus and CA3 subregions of the hippocampus.

    abstract:RATIONALE:The touchscreen continuous trial-unique non-matching-to-location task (cTUNL) has been developed to optimise a battery of tasks under NEWMEDS (Novel Methods leading to New Medication in Depression and Schizophrenia, http://www.newmeds-europe.com ). It offers novel task features of both a practical and a theor...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-015-4019-6

    authors: Oomen CA,Hvoslef-Eide M,Kofink D,Preusser F,Mar AC,Saksida LM,Bussey TJ

    更新日期:2015-11-01 00:00:00

  • [Effects of diazepam on exploratory behavior of pigs (author's transl)].

    abstract::The exploratory behavior of pigs was studied in two successive daily 20-mn sessions in a two-compartment box by counting the number of crossings from one compartment to the other and observing the activity patterns. Injection of 1 mg/kg diazepam before the first session increased the number of crossings without affect...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00431643

    authors: Dantzer R

    更新日期:1977-03-16 00:00:00

  • Cocaine facilitation of prefrontal cortex self-stimulation: a microstructural and pharmacological analysis.

    abstract::A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02801979

    authors: McGregor IS,Atrens DM,Jackson DM

    更新日期:1992-01-01 00:00:00

  • The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat.

    abstract:RATIONALE:Anticipatory nausea (AN) experienced by chemotherapy patients is resistant to current anti-nausea treatments. In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined. OBJECTIVE:The potential of cannabidiol (CBD) and the fatty a...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-007-0970-1

    authors: Rock EM,Limebeer CL,Mechoulam R,Piomelli D,Parker LA

    更新日期:2008-02-01 00:00:00

  • In vivo potency and efficacy of the novel cathinone α-pyrrolidinopentiophenone and 3,4-methylenedioxypyrovalerone: self-administration and locomotor stimulation in male rats.

    abstract:RATIONALE:Numerous substituted cathinone drugs have appeared in recreational use. This variety is often a response to legal actions; the scheduling of 3,4-methylenedioxypyrovalerone (MDPV; "bath salts") in the USA was followed by the appearance of the closely related drug α-pyrrolidinopentiophenone (alpha-PVP; "flakka"...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-015-3944-8

    authors: Aarde SM,Creehan KM,Vandewater SA,Dickerson TJ,Taffe MA

    更新日期:2015-08-01 00:00:00

  • DSP4 and Herrnstein's equation: further evidence for a role of noradrenaline in the maintenance of operant behaviour by positive reinforcement.

    abstract::The effect of the selective noradrenaline neurotoxin DSP4 on steady-state operant behaviour was examined using a quantitative behavioural paradigm based on Herrnstein's (1970) equation, which defines a hyperbolic relationship between steady-state response rate and reinforcement frequency in variable-interval schedules...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02180039

    authors: Morley MJ,Shah K,Bradshaw CM,Szabadi E

    更新日期:1988-01-01 00:00:00

  • Effects of alcohol consumption and alcohol expectancy on the categorisation of perceptual cues of emotional expression.

    abstract:RATIONALE:Evidence that alcohol leads to increased aggressive behaviour is equivocal and confounded by evidence that such effects may operate indirectly via expectancy. One mechanism by which alcohol consumption may increase aggressive behaviour is via alterations in the processing of emotional facial cues. OBJECTIVES...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-009-1463-1

    authors: Attwood AS,Ataya AF,Benton CP,Penton-Voak IS,Munafò MR

    更新日期:2009-06-01 00:00:00

  • A comparison of the acute behavioral effects of triazolam and temazepam in normal volunteers.

    abstract::Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behav...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02244887

    authors: Rush CR,Higgins ST,Hughes JR,Bickel WK

    更新日期:1993-01-01 00:00:00

  • Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): relationship to inhibition of brain adenosine deaminase.

    abstract::Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427798

    authors: Mendelson WB,Kuruvilla A,Watlington T,Goehl K,Paul SM,Skolnick P

    更新日期:1983-01-01 00:00:00

  • NCQ 298, a new selective iodinated salicylamide ligand for the labelling of dopamine D2 receptors.

    abstract::NCQ 298 ((S)-3-iodo-N-[(l-ethyl-2-pyrrolidinyl)methyl]-5,6- dimethoxysalicylamide) has an iodine substituent. We have labelled NCQ 298 with 123I and 125I, and used the radioligands as tracers in receptor studies in vitro, in vivo in autoradiography and in SPECT studies on Cynomolgus monkeys. [125I]NCQ 298 bound in vit...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244067

    authors: Hall H,Högberg T,Halldin C,Köhler C,Ström P,Ross SB,Larsson SA,Farde L

    更新日期:1991-01-01 00:00:00

  • Sleep pattern alterations by naloxone. Partial prevention by haloperidol.

    abstract::A continuous intravenous infusion of the opiate receptor antagonist naloxone, at doses ranging from 0.7 to 1.0 micrograms/kg/min (total dose 8.8-13.2 mg), was performed in eight normal subjects during the first 240 min of night sleep. A significant reduction in stage REM and in stage 4 percent duration was observed. P...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00429731

    authors: Cianchetti C,Masala C,Olivari P,Giordano G

    更新日期:1984-01-01 00:00:00

  • Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys: interaction with methamphetamine.

    abstract:RATIONALE:The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130000602

    authors: Ranaldi R,Anderson KG,Carroll FI,Woolverton WL

    更新日期:2000-12-01 00:00:00

  • Prolonged antidopaminergic actions of single doses of butyrophenones in the rat.

    abstract::Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acute anti-apomorphine ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00431801

    authors: Campbell A,Baldessarini RJ,Teicher MH,Kula NS

    更新日期:1985-01-01 00:00:00

  • Antagonism of oxotremorine-induced behavioral suppression by antimuscarinic drugs.

    abstract::The effects of benztropine, scopolamine, atropine, methylatropine, amitriptyline, phencyclidine, and meperidine were determined alone and in conjunction with a behaviorally suppressing dose (0.05 mg/kg IM) of oxotremorine in pigeons responding under a multiple fixed-ratio 30 fixed-interval 5-min schedule of grain pres...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00433492

    authors: Leander JD

    更新日期:1981-01-01 00:00:00

  • Differential effects of post-weaning juvenile stress on the behaviour of C57BL/6 mice in adolescence and adulthood.

    abstract:RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-010-1991-8

    authors: Peleg-Raibstein D,Feldon J

    更新日期:2011-03-01 00:00:00

  • Effects of combined escitalopram and aripiprazole in rats: role of the 5-HT1a receptor.

    abstract:RATIONALE:Pre-clinical and clinical studies have suggested that the antidepressant efficacy of escitalopram (ESC) can be augmented by co-administration of aripiprazole (ARI). OBJECTIVE:To establish if the effects of ESC + ARI can be altered by modulating the 5-HT1a receptor. METHODS:Sprague-Dawley male rats received ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05225-z

    authors: Lapointe T,Hudson R,Daniels S,Melanson B,Zhou Y,Leri F

    更新日期:2019-07-01 00:00:00

  • Histamine H3-receptor blockade in the rat nucleus basalis magnocellularis improves place recognition memory.

    abstract:RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of th...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130100892

    authors: Orsetti M,Ferretti C,Gamalero R,Ghi P

    更新日期:2002-01-01 00:00:00

  • A preliminary study of sex-related differences in prolactin responses to dopamine blockade and insulin hypoglycemia and in penfluridol plasma levels in schizophrenic patients.

    abstract::Twelve healthy chronic schizophrenic patients were treated with the long-acting oral dopamine (DA) receptor blocker penfluridol (100 mg orally) for 6 weeks. Plasma prolactin (PRL) levels were measured during insulin-tolerance tests (ITT) performed at the end of the drug-free period (7-10 days) and during weeks 1 and 6...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427494

    authors: Nathan RS,Sachar EJ,Ostrow L,Asnis GM,Halbreich U,Halpern F,Renzi NL,Slotnick V

    更新日期:1983-01-01 00:00:00

  • Stress reinstates heroin-seeking in drug-free animals: an effect mimicking heroin, not withdrawal.

    abstract::Exposure to 10 min of footshock stress (1 mA; 0.5 s on, with a mean off period of 40 s) reinstated heroin-seeking behavior in heroin-experienced, drug-free rats after many sessions of extinction and up to 6 weeks after last exposure to heroin. In reinstating the behavior, the footshock mimicked the effect of a non-con...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02246300

    authors: Shaham Y,Stewart J

    更新日期:1995-06-01 00:00:00

  • Repeated social-defeat stress, cocaine or morphine. Effects on behavioral sensitization and intravenous cocaine self-administration "binges".

    abstract:RATIONALE:Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants, particularly cocaine use during "binges." OBJECTIVE:Experimental protocols were designed to induce behavioral sensitization through exposures to social-defeat stress...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130100858

    authors: Covington HE 3rd,Miczek KA

    更新日期:2001-12-01 00:00:00