Abstract:
RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as these may help in developing treatment. MATERIALS AND METHODS:Post-mortem grey matter from Brodmann Area 21, 9 and 7 of 51 brains was assayed for ten neurochemical parameters indexing neurotransmission. Repeated measures analyses of variance were carried out for each parameter comparing groups (FTD vs AD vs control) at each anatomical site. RESULTS:In FTD only the indices of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, serotonin (5-HT)(1A) and 5-HT(2A) receptors were significantly reduced from control values. Of the ten parameters only 5-HT(1A) receptors showed significant group x site interaction. This reflected disproportionate reduction in frontal and temporal compared to parietal cortex. In FTD three other receptors (muscarinic, M(1), N-methyl-D: -aspartate, NMDA, and kainate), choline acetyltransferase (ChAT) activity, 5-HT and 5-hydroxyindoleacetic acid content and 5-HT reuptake site values were not significantly reduced from control values. Only 5-HT, 5-HT reuptake site and ChAT values were significantly higher in FTD than AD. NMDA receptor and ChAT values were significantly reduced from control only in AD. CONCLUSIONS:Neurochemical results in FTD indicate degeneration and loss of pyramidal neurones in frontotemporal neocortex, yet 5-HT afferents and 5-HT concentration, which are inhibitory on pyramidal neurones, were relatively preserved. This could lead to an excess of extraneural 5-HT causing underactivity of surviving pyramidal neurones. Pharmacotherapy with a 5-HT(1A) receptor antagonist may be indicated.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Bowen DM,Procter AW,Mann DM,Snowden JS,Esiri MM,Neary D,Francis PTdoi
10.1007/s00213-007-0992-8subject
Has Abstractpub_date
2008-03-01 00:00:00pages
603-10issue
4eissn
0033-3158issn
1432-2072journal_volume
196pub_type
杂志文章abstract::We have previously demonstrated that depletion of forebrain norepinephrine (NE) led to an attenuation of neophobia in a novel environment, as defined by a greater preference for novel food over familiar food. To study further the role of forebrain NE in neophobia we chronically infused noradrenergic receptor ligands o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02253601
更新日期:1992-01-01 00:00:00
abstract::Haloperidol has recently been found to be metabolized to its pyridinium ion (HP+). This conversion of haloperidol to HP+ appears to be similar to the activation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to N-methyl-4-phenyl pyridinium ion (MPP+). MPP+ is responsible for the dam...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246077
更新日期:1995-10-01 00:00:00
abstract::The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00428027
更新日期:1978-09-15 00:00:00
abstract::The 2-[14C]deoxyglucose method was used to compare the effects of the acute administration of cocaine by two different routes, intravenous and intraperitoneal, on rates of local cerebral glucose utilization in freely moving rats. Doses were initially chosen on the basis of their ability to elicit equivalent increases ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244931
更新日期:1993-01-01 00:00:00
abstract::SCH 39166 is the first selective D1-dopamine receptor antagonist developed for clinical trials in schizophrenia. SCH 39166 was evaluated as a radioligand for PET, labeled with 11C, and as a D1-dopamine receptor antagonist after single oral doses in healthy men. After intravenous injection of [11C]SCH 39166 distributio...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246067
更新日期:1995-10-01 00:00:00
abstract:RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1918-3
更新日期:2004-12-01 00:00:00
abstract::The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427276
更新日期:1983-01-01 00:00:00
abstract::The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00555228
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. OBJECTIVE:The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3030-z
更新日期:2013-07-01 00:00:00
abstract::The effects of flumazenil, a benzodiazepine receptor antagonist, on triazolam- and zolpidem-induced memory impairment were investigated. Sixty subjects received oral triazolam 0.5 mg, zolpidem 20.0 mg, or placebo at 10 a.m. (n = 20 per drug). Ninety minutes later, half of the subjects (n = 10) in each oral drug group ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02245635
更新日期:1995-09-01 00:00:00
abstract::The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426469
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:The motivational impetuses underlying self-administration of cocaine and other drugs of abuse are not fully understood. One emerging factor is affect. Both positive and negative affective states have been hypothesized to influence drug seeking and drug taking. In parallel, it has been posited that the ultraso...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1913-9
更新日期:2010-09-01 00:00:00
abstract:RATIONALE:Cannabinoid antagonists purportedly have greater effects in reducing the intake of highly palatable food compared to less palatable food. However, this assertion is based on free-feeding studies in which the amount of palatable food eaten under baseline conditions is often confounded with other variables, suc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3366-4
更新日期:2014-05-01 00:00:00
abstract:RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2060-y
更新日期:2005-05-01 00:00:00
abstract:RATIONALE:Despite animal evidence that methylenedioxymethamphetamine (ecstasy) causes lasting damage in brain regions related to long-term memory, results regarding human memory performance have been variable. This variability may reflect the cognitive complexity of the memory tasks. However, previous studies have test...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1766-2
更新日期:2010-03-01 00:00:00
abstract:RATIONALE:Longitudinal, population-based studies can better assess the relationship of ecstasy use with depression. OBJECTIVES:We examined whether change in ecstasy use was associated with change in depressive symptoms/probable depression over a 4-year period, among a large Australian sample. METHODS:The Personality ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3132-7
更新日期:2013-10-01 00:00:00
abstract::The rabbit classical eyeblink conditioning paradigm was used to assess the effects of haloperidol on hippocampal function. Haloperidol disrupted hippocampal activity and conditioned responses (CRs) at low but not high conditioned stimulus (CS) intensities. The observed relationship of hippocampal activity and the CR s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050237
更新日期:1997-04-01 00:00:00
abstract:RATIONALE:Non-contingent chronic nicotine exposure procedures have evolved rapidly in recent years, culminating in electronic nicotine delivery systems (ENDS or e-cigarettes) to deliver vaporized drugs to rodents in standard housing chambers. OBJECTIVES:The aim of the current work was to use ENDS to test concentration...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05400-2
更新日期:2020-03-01 00:00:00
abstract:RATIONALE:Although many studies have investigated the effects of gestational and lactational cocaine use on maternal behavior, few studies have examined the effects of prior adult cocaine use on maternal behavior. METHODS:In the current study, intraperitoneal cocaine or saline was administered to adult female rats for...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1777-z
更新日期:2010-03-01 00:00:00
abstract:RATIONALE:Acute ethanol administration induces hypothermia in genetically susceptible animals. Tolerance to this effect may develop with repeated administration. Allopregnanolone is an endogenously produced neuroactive steroid that acts at the GABA-A receptor. We postulated that allopregnanolone would induce hypothermi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1106-2
更新日期:2002-07-01 00:00:00
abstract::The serotonergic agent meta-chlorophenylpiperazine (m-CPP) increases temperature and plasma ACTH and other hormones and decreases social interaction, locomotor activity and food intake in rats, most likely via stimulation of 5-HT2C receptors. Repeated daily administration of m-CPP to rats induces rapid tolerance to th...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02805987
更新日期:1996-09-01 00:00:00
abstract::Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245832
更新日期:1995-03-01 00:00:00
abstract::The behavioral effects of intraventricularly (IVT) administered (-)-nicotine on food-maintained behavior were studied. Rats responded by pressing a lever under various fixed ratio (FR) schedules. Infusion of 5 microgram of (-)-nicotine suppressed responding under an FR 16 schedule for 11-13 min. The effect was inverse...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432762
更新日期:1982-01-01 00:00:00
abstract::Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439445
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1638-9
更新日期:2009-11-01 00:00:00
abstract::Pigeons were trained to peck each of two response keys. Periods during which pecks on one key (the food key) produced access to grain according to a random-ratio 80 schedule alternated irregularly with periods during which food-key responses had no scheduled consequences (extinction). Both keys remained amber unless a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00422418
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Traditional remedies prepared from Ptychopetalum olacoides (PO) are used throughout the Amazon to alleviate age-related conditions. These formulas are mainly used by elders, and alleged effects may be related to the anticholinesterase properties identified in a standardized ethanol extract of this species [P....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1272-y
更新日期:2009-01-01 00:00:00
abstract::Monoamine oxidase inhibitors (MAOIs) are widely accepted as effective antidepressants. Unfortunately their use has been limited by their capacity to potentiate dietary tyramine (the so called "cheese effect") and their interaction with other drugs. The latter poses a particular problem for patients undergoing anaesthe...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02246234
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Nicotine and other agonists of nicotinic cholinergic receptors (nAChR) have been shown to improve performance in specific memory domains in rodents and monkeys. Such beneficial effects are observed in preclinical models of age-related cognitive decline, stimulating interest in nAChR ligands as possible therap...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1804-z
更新日期:2004-09-01 00:00:00
abstract::This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticonvulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to incr...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00428416
更新日期:1985-01-01 00:00:00