Abstract:
RATIONALE:Non-contingent chronic nicotine exposure procedures have evolved rapidly in recent years, culminating in electronic nicotine delivery systems (ENDS or e-cigarettes) to deliver vaporized drugs to rodents in standard housing chambers. OBJECTIVES:The aim of the current work was to use ENDS to test concentration-dependent effects of nicotine e-cigarette vapor inhalation on blood-nicotine concentrations, blood-cotinine concentrations, and somatic withdrawal signs over time in rats. METHODS:Male Wistar rats were exposed to vapor containing various concentrations of nicotine (20, 40, 80 mg/mL) for 11 days through ENDS, and blood concentrations of nicotine and cotinine, the major proximate metabolite of nicotine, as well as spontaneous and precipitated somatic withdrawal signs, were measured over time (across days of exposure and over hours after termination of vapor exposure). RESULTS:Exposing male Wistar rats to non-contingent nicotine vapor inhalation through ENDS produces somatic withdrawal symptoms and measurable blood-nicotine and blood-cotinine levels that change according to (1) concentration of nicotine in vape solution, (2) number of days of nicotine vapor exposure, (3) time since termination of nicotine vapor exposure, and (4) relative to the withdrawal signs, whether withdrawal was spontaneous or precipitated (by mecamylamine). CONCLUSIONS:The data presented here provide parameters that can be used as a reasonable starting point for future work that employs ENDS to deliver non-contingent nicotine vapor in rats, although many parameters can and should be altered to match the specific goals of future work.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Montanari C,Kelley LK,Kerr TM,Cole M,Gilpin NWdoi
10.1007/s00213-019-05400-2subject
Has Abstractpub_date
2020-03-01 00:00:00pages
613-625issue
3eissn
0033-3158issn
1432-2072pii
10.1007/s00213-019-05400-2journal_volume
237pub_type
杂志文章abstract::Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00216063
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Group I metabotropic glutamate receptor antagonists, which block both the mGlu1 and mGlu5 receptors, have been shown to have anxiolytic effects in the lick suppression test in rats. OBJECTIVE:The anxiolytic potential of the selective mGlu1 antagonist 3,4-dihydro-2H-pyrano[2,3]beta-quinolin-7-yl)(cis-4-methox...
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doi:10.1007/s00213-004-2056-7
更新日期:2005-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442814
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no approved treatment exists for the cognitive symptoms. There is thus a great need for research aiming at identifying novel targets for treatment of this indicati...
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pub_type: 杂志文章
doi:10.1007/s00213-010-2039-9
更新日期:2011-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432441
更新日期:1981-01-01 00:00:00
abstract::The development of a differential tolerance to morphine was investigated with respect to the mean effective dose, the threshold dose of tolerance, the degree of tolerance after a fixed dose, and the speed of tolerance loss. The mean effective doses, the threshold doses of tolerance, and the degree of tolerance differe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428157
更新日期:1982-01-01 00:00:00
abstract::There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days wit...
journal_title:Psychopharmacology
pub_type: 杂志文章
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abstract::The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species. ...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00176837
更新日期:1988-01-01 00:00:00
abstract::Ethanol-induced locomotor stimulation has been proposed to be positively correlated with the rewarding effects of ethanol (Wise and Bozarth 1987). The present experiments provided a test of this hypothesis using a genetic model. Three behavioral indices of the motivational effects of ethanol (drinking, taste condition...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245064
更新日期:1994-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432273
更新日期:1979-03-28 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050711
更新日期:1998-10-01 00:00:00
abstract::The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
abstract::Voluntary consumption of alcohol by rats (i.e. in the absence of food or water deprivation, sweetening of the alcohol solution, etc.) that results in the attainment of behaviorally significant or pharmacologically detectable blood alcohol levels (BALs) has been difficult to demonstrate. In this study, we showed that f...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177925
更新日期:1987-01-01 00:00:00
abstract::The effects of single and long-term haloperidol administration on rat open field behavior was studied. Withdrawal from long-term haloperidol treatment induced a significant increase in all parameters of activity recorded, except rearing. There was a direct relationship between the impairment of motor function induced ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429212
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...
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pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS:Twelve participants ('dual users' of EC and cigarettes) used their own brand cigaret...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4512-6
更新日期:2017-03-01 00:00:00
abstract:RATIONALE:The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while respondi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4389-4
更新日期:2016-10-01 00:00:00
abstract:RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...
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pub_type: 杂志文章
doi:10.1007/s00213-020-05463-6
更新日期:2020-05-01 00:00:00
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doi:10.1007/s00213-011-2274-8
更新日期:2011-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00492216
更新日期:1979-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246149
更新日期:1995-07-01 00:00:00
abstract:RATIONALE:H(3)-receptor inverse agonists raise a great interest as innovative therapeutics in several central disorders. Whereas their procognitive properties are well established, their antipsychotic-like properties are still debated. OBJECTIVES:We further explored the effect of maximal doses (3-10 mg/kg) of ciproxif...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1863-2
更新日期:2010-07-01 00:00:00
abstract::We examined the possibility that anoxia at birth can alter behavioral sensitization to amphetamine during adulthood. Male rats born either vaginally or by Cesarean section with or without an additional 15-min period of anoxia received five once-daily injections of either d-amphetamine (2.0 mg/kg, i.p.) or vehicle or n...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050419
更新日期:1997-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1907-7
更新日期:2010-09-01 00:00:00
abstract::Chronic exposure to very mild unpredictable stress has previously been found to depress the consumption of, and preference for, highly palatable sweet solutions. The present study used the place conditioning procedure to investigate whether these effects result from a decreased sensitivity to reward. Rats were subject...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244188
更新日期:1991-01-01 00:00:00
abstract::Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429002
更新日期:1983-01-01 00:00:00
abstract::This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245224
更新日期:1994-01-01 00:00:00
abstract:RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2282-8
更新日期:2011-09-01 00:00:00
abstract:RATIONALE:Although newer interview methods such as Structured Interview Guide for the Montgomery-Asberg Depression Rating Scale (SIGMA; MADRS) with audiotaping and Rater Applied Performance Scale (RAPS) appraisal have been introduced to improve reliability of ratings in antidepressant clinical trials, there is limited ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3584-4
更新日期:2014-11-01 00:00:00