Acute effects of self-paced walking on urges to smoke during temporary smoking abstinence.

abstract：RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...

journal_title：Psychopharmacology

authors： Sarter M,Martinez V,Kozak R

更新日期：2009-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular...

journal_title：Psychopharmacology

authors： Kuehl LK,Muhtz C,Hinkelmann K,Dettenborn L,Wingenfeld K,Spitzer C,Otte C

更新日期：2016-09-01 00:00:00

abstract：RATIONALE:Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and...

journal_title：Psychopharmacology

authors： Dwyer JM,Rizzo SJ,Neal SJ,Lin Q,Jow F,Arias RL,Rosenzweig-Lipson S,Dunlop J,Beyer CE

更新日期：2009-03-01 00:00:00

abstract：:Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...

journal_title：Psychopharmacology

authors： Davis RE,Sant WW,Ellison G

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibitio...

journal_title：Psychopharmacology

authors： Su B,Li S,Yang L,Zheng M

更新日期：2020-04-01 00:00:00

abstract：:The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...

journal_title：Psychopharmacology

authors： Garcha HS,Thomas P,Spivak CE,Wonnacott S,Stolerman IP

更新日期：1993-01-01 00:00:00

abstract：:Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...

journal_title：Psychopharmacology

authors： Gerlach J,Christensen JK,Christensen TL,Elley J,Jensen JP,Larsen SB

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...

journal_title：Psychopharmacology

authors： Harvey AJ,Bayless SJ,Hyams G

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...

journal_title：Psychopharmacology

authors： Rowlett JK,Woolverton WL

更新日期：1996-11-01 00:00:00

abstract：:Young adult rats (5 months) were compared with aged (28 months) rats in their ability to learn and perform in a diazepam drug discrimination. Both groups of rats were drug naive at the onset of the experiment. Adult and aged animals learned to discriminate diazepam. In general, the response rates under both drug and v...

journal_title：Psychopharmacology

authors： Amrick CL,Bennett DA

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Recent studies have shown that metabotropic glutamate receptor 5 (mGluR5) can modulate N-methyl-D-aspartate (NMDA) receptor function in vivo. For example, the mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate PCP (phencyclidine)-evoked hyperactivity and PCP-induced disruptions in pr...

journal_title：Psychopharmacology

authors： Campbell UC,Lalwani K,Hernandez L,Kinney GG,Conn PJ,Bristow LJ

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Converging evidence suggests that dopaminergic and serotonergic mechanisms affect distinct aspects of cognitive performance. Experiments using the rodent five-choice reaction time task have established a critical role for dopaminergic mechanisms in the rat medial prefrontal cortex (mPFC), but have yielded onl...

journal_title：Psychopharmacology

authors： Passetti F,Dalley JW,Robbins TW

更新日期：2003-01-01 00:00:00

abstract：:The behavioral performance of inbred mouse strains was examined in animal models of anxiety to evaluate the potential contribution of genetic factors to fear-motivated behaviors. The preference that randomly bred mice and rats exhibit for the enclosed as opposed to the open arms of an elevated maze has been considered...

journal_title：Psychopharmacology

authors： Trullas R,Skolnick P

更新日期：1993-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Previous studies show that electrical stimulation of the ventral subiculum (vSub) can reinstate drug-seeking behavior in rats following extinction. This study examined whether vSub stimulation could also evoke reinitiation of d-amphetamine (d-AMPH) self-administration during voluntary abstinenc...

journal_title：Psychopharmacology

authors： Taepavarapruk P,Phillips AG

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:A substantial portion of cigarette smokers prefer menthol-flavored cigarettes. To date, however, no studies have examined whether menthol in cigarettes has central pharmacological effects. OBJECTIVE:We investigated psychophysiological and subjective effects of smoking menthol versus non-menthol cigarettes in...

journal_title：Psychopharmacology

authors： Pritchard WS,Houlihan ME,Guy TD,Robinson JH

更新日期：1999-04-01 00:00:00

abstract：:The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...

journal_title：Psychopharmacology

authors： Blander A,Hunt T,Blair R,Amit Z

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:To date, the literature on the intravenous self-administration of cocaine by laboratory animals lacks a compelling demonstration of an ascending limb to the dose-response function. It has been argued that previous demonstrations of an ascending limb are confounded by the extinction process. OBJECTIVE:The obj...

journal_title：Psychopharmacology

authors： Flory GS,Woods JH

更新日期：2003-02-01 00:00:00

abstract：:Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether sc...

journal_title：Psychopharmacology

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-09-01 00:00:00

abstract：:Biotransformation of phenacetin via O-deethylation to acetaminophen, an index reaction reflecting activity of Cytochrome P450-1A2, was studied in microsomal preparations from a series of human livers. Acetaminophen formation was consistent with a double Michaelis-Menten system, with low-Km (mean Km1 = 68 microM) and h...

journal_title：Psychopharmacology

authors： von Moltke LL,Greenblatt DJ,Duan SX,Schmider J,Kudchadker L,Fogelman SM,Harmatz JS,Shader RI

更新日期：1996-12-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The mechanisms underlying relapse to cocaine seeking induced by exposure to priming cocaine injections, cues associated with cocaine self-administration and environmental stressors have been studied in rats. Here we describe a reinstatement method for studying relapse to cocaine seeking in mice...

journal_title：Psychopharmacology

authors： Highfield DA,Mead AN,Grimm JW,Rocha BA,Shaham Y

更新日期：2002-06-01 00:00:00

abstract：:A two flavour, unbiased, taste preference conditioning procedure was used to test for possible motivating effects of gamma 2-MSH. Three training trials failed to produce any significant effect with doses ranging from 2.4 to 40 micrograms/ICV infusion in drug-naive, non-operated or placebo-implanted rats. However, in r...

journal_title：Psychopharmacology

authors： Mucha RF,van Ree JM

更新日期：1989-01-01 00:00:00

abstract：:A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...

journal_title：Psychopharmacology

authors： Kilts CD,Commissaris RL,Rech RH

更新日期：1981-01-01 00:00:00

abstract：:Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...

journal_title：Psychopharmacology

authors： Smith JB,McKearney JW

更新日期：1977-07-18 00:00:00

abstract：BACKGROUND:Emerging data indicate the neuromodulator adenosine may play a role in the therapeutics of schizophrenia. Adenosine A(2A) receptor stimulation exerts a functional antagonism at postsynaptic D(2) receptors. Data from animal models relevant to schizophrenia support a therapeutic effect of modulating adenosiner...

journal_title：Psychopharmacology

authors： Wonodi I,Gopinath HV,Liu J,Adami H,Hong LE,Allen-Emerson R,McMahon RP,Thaker GK

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Repeated treatment with morphine has been shown to sensitize rats to its stimulant effects on motor activity and mesolimbic dopamine (DA) transmission. OBJECTIVES:The aim of this study is to investigate if morphine sensitization is associated to changes in the behavioral reactions to appetitive and aversive ...

journal_title：Psychopharmacology

authors： De Luca MA,Bimpisidis Z,Bassareo V,Di Chiara G

更新日期：2011-08-01 00:00:00

abstract：:The increasing interest in subjective well-being and quality of life of schizophrenic patients represents a conceptual shift in therapeutic outcome criteria. Symptom reduction alone was the most essential outcome parameter for a long time; with the development of atypical antipsychotics more ambitious success criteria...

journal_title：Psychopharmacology

authors： Karow A,Naber D

更新日期：2002-06-01 00:00:00

abstract：:Changes in saccadic eye movements before and after up to 10 mg oral diazepam were measured electrooculographically in diazepam-naive humans. Diazepam produced dose-dependent increases in saccade duration and decreases in maximum saccade velocity over a 2--36 degrees range of saccade amplitudes. The magnitude of drug-i...

journal_title：Psychopharmacology

authors： Rothenberg SJ,Selkoe D

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder. OBJECTIVES:The study evaluated the efficacy and safety of s...

journal_title：Psychopharmacology

authors： Li H,Gu N,Zhang H,Wang G,Tan Q,Yang F,Ning Y,Zhang H,Lu Z,Xu X,Shi J,Gao C,Li L,Zhang K,Tian H,Wang X,Li K,Li H,Xu Y,Xie S,Yu X

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:In humans, the retrieval of memories associated with an alcohol-related experience frequently evokes alcohol-seeking behaviour. The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval. OBJECTIVES:The aim of our study was ...

journal_title：Psychopharmacology

authors： von der Goltz C,Vengeliene V,Bilbao A,Perreau-Lenz S,Pawlak CR,Kiefer F,Spanagel R

更新日期：2009-08-01 00:00:00

abstract：:The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...

journal_title：Psychopharmacology

authors： Rebec GV,White IM,Puotz JK

更新日期：1997-04-01 00:00:00