Repeated methylphenidate treatment induces behavioral sensitization and decreases protein kinase A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum.

abstract：:Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...

journal_title：Psychopharmacology

authors： Wei ET

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...

journal_title：Psychopharmacology

authors： Uhlírová L,Sustková-Fiserová M,Krsiak M

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited. OBJECTIVES:We sought to extend past findings by examining dose-response curves that overlap with the individual d...

journal_title：Psychopharmacology

authors： Bechtholt-Gompf AJ,Smith KL,John CS,Kang HH,Carlezon WA Jr,Cohen BM,Ongür D

更新日期：2011-06-01 00:00:00

abstract：:The effects of scopolamine, an anticholinergic drug, of trimipramine, a tricyclic antidepressant with both anticholinergic and sedative properties, of diazepam and a placebo, on explicit memory and repetition priming were assessed using a free-recall task and a word-stem completion task. Forty-eight healthy volunteers...

journal_title：Psychopharmacology

authors： Danion JM,Zimmermann MA,Willard-Schroeder D,Grangé D,Welsch M,Imbs JL,Singer L

更新日期：1990-01-01 00:00:00

abstract：:The four homoeopathic drugs, Gelsemium, Cannabis Indica, Graphites and Agaricus Muscarius, administered orally in 30th and 200th potencies on white rats, enhanced restraint-induced catalepsy in a similar manner to the two standard drugs pilocarpine and haloperidol (IP injection at 5 mg/kg). All the drugs tested differ...

journal_title：Psychopharmacology

authors： Sukul NC,Bala SK,Bhattacharyya B

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Nicotine and other agonists of nicotinic cholinergic receptors (nAChR) have been shown to improve performance in specific memory domains in rodents and monkeys. Such beneficial effects are observed in preclinical models of age-related cognitive decline, stimulating interest in nAChR ligands as possible therap...

journal_title：Psychopharmacology

authors： Katner SN,Davis SA,Kirsten AJ,Taffe MA

更新日期：2004-09-01 00:00:00

abstract：:Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...

journal_title：Psychopharmacology

authors： Piccirillo M,Alpert JE,Cohen DJ,Shaywitz BA

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Depression is a frequent non-motor symptom in Parkinson's disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is ...

journal_title：Psychopharmacology

authors： Felicio AC,Moriyama TS,Godeiro-Junior C,Shih MC,Hoexter MQ,Borges V,Silva SM,Amaro-Junior E,Andrade LA,Ferraz HB,Bressan RA

更新日期：2010-07-01 00:00:00

abstract：:Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the "effect size", such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few...

journal_title：Psychopharmacology

authors： Quitkin FM

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal...

journal_title：Psychopharmacology

authors： Buchmann AF,Zohsel K,Blomeyer D,Hohm E,Hohmann S,Jennen-Steinmetz C,Treutlein J,Becker K,Banaschewski T,Schmidt MH,Esser G,Brandeis D,Poustka L,Zimmermann US,Laucht M

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:Although some aspects of memory functions are known to be acutely impaired by delta(9)-tetrahydrocannabinol (delta(9)-THC; the main active constituent of marijuana), effects on other aspects of memory are not known and the time course of functional impairments is unclear. OBJECTIVE:The present study aimed to...

journal_title：Psychopharmacology

authors： Curran HV,Brignell C,Fletcher S,Middleton P,Henry J

更新日期：2002-10-01 00:00:00

abstract：:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...

journal_title：Psychopharmacology

authors： Heinrichs SC,Klaassen A,Koob GF,Schulteis G,Ahmed S,De Souza EB

更新日期：1998-04-01 00:00:00

abstract：RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...

journal_title：Psychopharmacology

authors： Woolverton WL,Freeman KB,Myerson J,Green L

更新日期：2012-04-01 00:00:00

abstract：:It has previously been shown that serotonergic [5-hydroxytryptamine (5-HT)] neurons of the median raphe nucleus (MR) are critically involved in the control of the hippocampal electroencephalogram (EEG). Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hi...

journal_title：Psychopharmacology

authors： Kinney GG,Kocsis B,Vertes RP

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving--though long suspected--remains elusive. MATERIALS AND METHODS:We employed laboratory exposure to stress, alcohol cue, and neu...

journal_title：Psychopharmacology

authors： Mangieri RA,Hong KI,Piomelli D,Sinha R

更新日期：2009-07-01 00:00:00

abstract：:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...

journal_title：Psychopharmacology

authors： Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko S

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) cont...

journal_title：Psychopharmacology

authors： Isola R,Zhang H,Tejwani GA,Neff NH,Hadjiconstantinou M

更新日期：2009-01-01 00:00:00

abstract：:A study was performed to examine behavioral response to a challenge of selective dopamine D-1 and D-2 agonists in rats previously sensitized by subchronic administration of methamphetamine or cocaine. Rats in three groups received repeated injections (IP) of saline, methamphetamine (4 mg/kg/day) or cocaine (20 mg/kg/d...

journal_title：Psychopharmacology

authors： Ujike H,Akiyama K,Otsuki S

更新日期：1990-01-01 00:00:00

abstract：:Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...

journal_title：Psychopharmacology

authors： Weiner I,Feldon J,Ben-Horin E

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Rice KC,Traynor JR,Woods JH

更新日期：2005-11-01 00:00:00

abstract：:Animals responding for biphasic square wave stimulation to the VTA were treated for 26 days with a low dose (0.07 mg/kg) of the neuroleptic haloperidol and tested at 1 h post-injection. Initially the drug induced a pronounced lateral displacement of the baseline rate-intensity function, concomitant with a depression i...

journal_title：Psychopharmacology

authors： Lynch MR,Carey RJ

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Ayahuasca is a traditional South American psychoactive beverage and the central sacrament of Brazilian-based religious groups, with followers in Europe and the United States. The tea contains the psychedelic indole N,N-dimethyltryptamine (DMT) and beta-carboline alkaloids with monoamine oxidase-inhibiting pr...

journal_title：Psychopharmacology

authors： Barbanoj MJ,Riba J,Clos S,Giménez S,Grasa E,Romero S

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:The dopaminergic system has been proposed to mediate alcohol-induced locomotor activity, yet the mechanisms underlying this behavioral response remain poorly understood. OBJECTIVES:This study was conducted to investigate the role of dopamine D2-like receptors in mediating alcohol-induced behavioral responses...

journal_title：Psychopharmacology

authors： Tran S,Facciol A,Gerlai R

更新日期：2016-06-01 00:00:00

abstract：:The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...

journal_title：Psychopharmacology

authors： Weiskrantz L,Mondadori C

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...

journal_title：Psychopharmacology

authors： Rendell PG,Gray TJ,Henry JD,Tolan A

更新日期：2007-11-01 00:00:00

abstract：RATIONALE:Phytocannabinoids are useful therapeutics for multiple applications including treatments of constipation, malaria, rheumatism, alleviation of intraocular pressure, emesis, anxiety and some neurological and neurodegenerative disorders. Consistent with these medicinal properties, extracted cannabinoids have rec...

journal_title：Psychopharmacology

authors： Deiana S,Watanabe A,Yamasaki Y,Amada N,Arthur M,Fleming S,Woodcock H,Dorward P,Pigliacampo B,Close S,Platt B,Riedel G

更新日期：2012-02-01 00:00:00

abstract：RATIONALE:The cholinergic system is linked extensively to memory, but its exact role remains controversial. In particular, scopolamine-induced impairment in rodents is not task specific, which may be due to difficulty in developing rodent protocols to assess deficits in recent memory, in which the remembered event is b...

journal_title：Psychopharmacology

authors： Araujo JA,Chan AD,Winka LL,Seymour PA,Milgram NW

更新日期：2004-08-01 00:00:00

abstract：RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...

journal_title：Psychopharmacology

authors： Rhodes SM,Coghill DR,Matthews K

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...

journal_title：Psychopharmacology

authors： Langleben DD,Busch EL,O'Brien CP,Elman I

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...

journal_title：Psychopharmacology

authors： Temple JL,Ziegler AM,Graczyk A,Bendlin A,O'Leary S,Schnittker YS

更新日期：2012-09-01 00:00:00