Abstract：
RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine would decrease its effectiveness, and whether the effects of delay could be described within a delay discounting framework. METHODS:Monkeys were implanted with double-lumen catheters to allow separate injection of cocaine and histamine. In discrete trials, subjects first chose between cocaine (50 or 100 μg/kg/inj) alone and an injection of the same dose of cocaine followed immediately by an injection of histamine (0.37-50 μg/kg). Next, they chose between cocaine followed immediately by histamine and cocaine followed by an equal but delayed dose of histamine. RESULTS:When choosing between cocaine alone and cocaine followed immediately by histamine, preference increased with histamine dose from indifference to >80% choice of cocaine alone. When choosing between cocaine followed by immediate histamine and cocaine followed by delayed histamine, monkeys showed strong position preferences. When delayed histamine was associated with the nonpreferred position, preference for that option increased with delay from ≤30% to >85%. The corresponding decrease in choice of the preferred position was well described by a hyperboloid discounting function. CONCLUSIONS:Histamine can function as a punisher in the choice between injections of cocaine and delay can decrease its effectiveness as a punisher. The effects of delaying punishment of drug self-administration can be conceptualized within the delay discounting framework.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Woolverton WL,Freeman KB,Myerson J,Green Ldoi
10.1007/s00213-011-2501-3subject
Has Abstractpub_date
2012-04-01 00:00:00pages
509-17issue
3eissn
0033-3158issn
1432-2072journal_volume
220pub_type
杂志文章abstract：:The effect of 15 min/day of immobilization (IM) stress on oral self-administration (SA) of morphine (0.5 mg/ml) or fentanyl (25 micrograms/ml) and withdrawal was examined in rats. In addition, the role of conditioning factors in these effects was assessed. For each drug, four groups of subjects were exposed for 50 day...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02253539
更新日期：1993-01-01 00:00:00
abstract：:Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00187246
更新日期：1987-01-01 00:00:00
abstract：:Phencyclidine (PCP; 2.5 or 5.0 mg/kg) potentiated the effects of rewarding hypothalamic brain stimulation, causing parallel leftward shifts of the functions that relate rate of responding to stimulation frequency. Thus, like a number of other drugs of abuse, PCP lowered the "dose" of stimulation required to maintain r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02253528
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Successive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonge...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3905-2
更新日期：2015-08-01 00:00:00
abstract：RATIONALE:Fluoxetine (Prozac®) is the most frequently prescribed drug to battle depression in pregnant women, but its safety in the unborn child has not yet been established. Fluoxetine, a selective serotonin reuptake inhibitor, crosses the placenta, leading to increased extracellular serotonin levels and potentially n...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2299-z
更新日期：2011-10-01 00:00:00
abstract：RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05687-6
更新日期：2021-02-01 00:00:00
abstract：RATIONALE:A glutamate-dopamine interaction has been implicated in the psychosis-like effects of glutamate N-methyl- D-aspartate (NMDA) receptor antagonists, such as phencyclidine and ketamine. However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man have been controvers...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1236-6
更新日期：2002-12-01 00:00:00
abstract：AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin re...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4664-z
更新日期：2017-08-01 00:00:00
abstract：:The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244133
更新日期：1990-01-01 00:00:00
abstract：:Rats were trained to discriminate between two compound stimulus arrays that included exteroceptive (ES) and interoceptive (IS) stimulus components. The ES components were illumination and tactile cues, and the IS components were produced by d-amphetamine (A) or Na pentobarbital (P) treatment (drug versus drug discrimi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174076
更新日期：1986-01-01 00:00:00
abstract：:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050563
更新日期：1998-04-01 00:00:00
abstract：:Functional antagonists at the N-methyl-D-aspartate (NMDA) receptor complex produce anti-depressant-like actions in preclinical models. Thus, an injection of a glycine partial agonist (1-aminocyclopropanecarboxylic acid; ACPC), a competitive NMDA antagonist (2-amino-7-phosphonoheptanoic acid; AP-7) or a use-dependent c...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245261
更新日期：1992-01-01 00:00:00
abstract：:This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245224
更新日期：1994-01-01 00:00:00
abstract：:The behavioral performance of inbred mouse strains was examined in animal models of anxiety to evaluate the potential contribution of genetic factors to fear-motivated behaviors. The preference that randomly bred mice and rats exhibit for the enclosed as opposed to the open arms of an elevated maze has been considered...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244948
更新日期：1993-01-01 00:00:00
abstract：:The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00212851
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Most adult smokers start smoking during their adolescence. This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence. OBJECTIVE:To test the hypothesis that ado...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1758-6
更新日期：2004-07-01 00:00:00
abstract：:Human CSF cyclic AMP and cyclic GMP have been measured as possible indicators of activity of central neurotransmitter-sensitive adenylate or guanylate cyclase. In an attempt to help to identify the specific neurotransmitter systems of origin of human CSF cyclic AMP and GMP, we studied Parkinson patients with and with...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427396
更新日期：1978-07-19 00:00:00
abstract：RATIONALE:Whilst the deleterious effects of alcohol on retrospective remembering have been widely documented, no study has yet objectively determined alcohol's effects on prospective memory (PM)--remembering to do something in the future. OBJECTIVES:With this aim, the present study determined the acute effects of alco...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1546-z
更新日期：2009-08-01 00:00:00
abstract：:Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice. Repeated administration (5 times at 3 to 4-day intervals) of MAP, but not CAF, induced sensitization to its effect. Furthermore, the mice repeatedly receiving CAF showed no significant ch...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245053
更新日期：1994-10-01 00:00:00
abstract：:A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02801979
更新日期：1992-01-01 00:00:00
abstract：:Acute (50.0 mg/kg) and repeated (0.1-10.0 mg/kg) administration of dihydroergosine (DHESN) to rats over 5 days lowered the concentration of 5-HIAA in the brain. DHESN given acutely increased the brain 5-HT in p-CPA-treated animals and diminished the probenecid-induced increase in brain 5-HIAA. In pargyline-treated rat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00172881
更新日期：1986-01-01 00:00:00
abstract：:MA rats, bred for greater motor impairment following subhypnotic doses of ethanol, were found to be more sensitive to the hypnotic effects of phenobarbital and chloral hydrate than were LA rats. In addition, the previously reported finding of a difference between the two lines of rats in duration of loss of righting r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426674
更新日期：1979-02-28 00:00:00
abstract：:To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00426885
更新日期：1978-04-28 00:00:00
abstract：RATIONALE:Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues. OBJECTIVES:Here,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4627-4
更新日期：2017-08-01 00:00:00
abstract：RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-006-0588-8
更新日期：2006-12-01 00:00:00
abstract：RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05462-7
更新日期：2020-05-01 00:00:00
abstract：:This study evaluated the effects of two central nicotinic-cholinergic receptor agonists and an antagonist on performance accuracy of a rat, delayed stimulus discrimination task (DSDT). Rats were trained to discriminate between an auditory and visual stimulus by pressing a right or left lever. To diminish the rat's abi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246174
更新日期：1996-01-01 00:00:00
abstract：:This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427774
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000422
更新日期：2000-06-01 00:00:00
abstract：RATIONALE:The ability of tobacco harm reduction strategies to produce significant reductions in toxin exposure is limited by compensatory increases in smoking behavior. Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon and assessing ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1567-7
更新日期：2009-09-01 00:00:00
