Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse.

Abstract:

AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin receptor (5-HT4R) partial agonist, RS-67333, to counterbalance deficits in short- and long-term memory. To select sub-efficacious doses of both drugs, dose-response studies were first performed on the scopolamine-induced deficits of spontaneous alternation in the Y-maze task and of acquisition and retrieval processes in a passive avoidance task. RESULT:For spontaneous alternation behavior, combination of 1 mg/kg galantamine and 0.5 mg/kg RS-67333 fully reversed the deficit. In the passive avoidance task, no sub-efficacious doses could be found in the retention paradigm, but a beneficial effect of the association has been demonstrated in the acquisition paradigm. CONCLUSION:Mnesic effects of galantamine can be thus potentiated by activation of 5-HT4R. Such a combination treatment might (1) strengthen symptomatic relief, (2) attenuate adverse effects given the lower doses of each compound required, and (3) afford a disease-modifying effect given the known action of 5-HT4R on amyloidogenesis cascade.

journal_title

Psychopharmacology

authors

Freret T,Lelong-Boulouard V,Lecouflet P,Hamidouche K,Dauphin F,Boulouard M

doi

10.1007/s00213-017-4664-z

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

2365-2374

issue

15

eissn

0033-3158

issn

1432-2072

pii

10.1007/s00213-017-4664-z

journal_volume

234

pub_type

杂志文章
  • On the positive and negative affective responses to cocaine and their relation to drug self-administration in rats.

    abstract:RATIONALE:Acute cocaine administration produces an initial rewarding state followed by a dysphoric/anxiogenic "crash." OBJECTIVE:The objective of this study was to determine whether individual differences in the relative value of cocaine's positive and negative effects would account for variations in subsequent drug s...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-015-3873-6

    authors: Ettenberg A,Fomenko V,Kaganovsky K,Shelton K,Wenzel JM

    更新日期:2015-07-01 00:00:00

  • A retrospective study on the long-term efficacy of clozapine in 96 schizophrenic and schizoaffective patients during a 13-year period.

    abstract::The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00442567

    authors: Lindström LH

    更新日期:1989-01-01 00:00:00

  • Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in rats.

    abstract:RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-003-1703-8

    authors: Cervo L,Cocco A,Carnovali F

    更新日期:2004-04-01 00:00:00

  • Reproductive experience alters the involvement of N-methyl-D-aspartate receptors in fear extinction, but not fear conditioning, in female Sprague Dawley rats.

    abstract::Recently, evidence has emerged showing that the behavioural and hormonal features of fear extinction are altered as a result of reproductive experience in both rats and humans. The current set of experiments sought to determine whether reproductive experience also alters the molecular features of fear extinction. In a...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-018-4956-y

    authors: Tang S,Graham BM

    更新日期:2019-01-01 00:00:00

  • The effects of dopamine agonists on prepulse inhibition in healthy men depend on baseline PPI values.

    abstract:RATIONALE AND OBJECTIVES:Dopamine (DA) agonists reliably disrupt prepulse inhibition (PPI) of the startle reflex in animals but less so in humans despite cross-species similarities in the neural regulation of PPI. This study examines whether individual variation in baseline PPI may account for the inconsistencies in DA...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-005-0056-x

    authors: Bitsios P,Giakoumaki SG,Frangou S

    更新日期:2005-10-01 00:00:00

  • Depression and senile dementia of the Alzheimer type: a role for moclobemide.

    abstract::Depression is common in patients with senile dementia of the Alzheimer type (SDAT) and may precede the onset of the dementia; the underlying biological and neurotransmitter mechanisms may be common to both diseases, so far as norepinephrine lesions are concerned. The major routes of metabolism of amines in the brain u...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02246259

    authors: Chan-Palay V

    更新日期:1992-01-01 00:00:00

  • 2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and α2-adrenergic receptors.

    abstract:RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05207-1

    authors: Halberstadt AL,Brandt SD,Walther D,Baumann MH

    更新日期:2019-03-01 00:00:00

  • Comparison of alprazolam plasma levels in normal Asian and Caucasian male volunteers.

    abstract::Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00216063

    authors: Lin KM,Lau JK,Smith R,Phillips P,Antal E,Poland RE

    更新日期:1988-01-01 00:00:00

  • Profile of acute tolerance to three sedative anxiolytics.

    abstract::Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427800

    authors: Ellinwood EH Jr,Linnoila M,Easler ME,Molter DW

    更新日期:1983-01-01 00:00:00

  • Kappa opioids and the modulation of pain.

    abstract:BACKGROUND AND RATIONALE:Pain is a complex sensory experience, involving cognitive factors, environment (setting, society, and culture), experience, and gender and is modulated significantly by the central nervous system (CNS). The mechanisms by which opioid analgesics work are understood, but this class of drugs is no...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-010-1819-6

    authors: Kivell B,Prisinzano TE

    更新日期:2010-06-01 00:00:00

  • Glucocorticoid mechanisms may contribute to ECT-induced retrograde amnesia.

    abstract:RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0593-y

    authors: Nagaraja N,Andrade C,Sudha S,Madan Singh N,Chandra JS,Venkataraman BV

    更新日期:2007-01-01 00:00:00

  • Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity.

    abstract:RATIONALE:Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear. OBJECTIVES:To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gen...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-005-0104-6

    authors: Clark L,Roiser JP,Cools R,Rubinsztein DC,Sahakian BJ,Robbins TW

    更新日期:2005-11-01 00:00:00

  • Discriminative stimulus properties of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)DOI] in C57BL/6J mice.

    abstract:RATIONALE:The drug discrimination procedure has proven to be a valuable tool for studying the mechanism of action of psychoactive drugs. Recently, mice with targeted gene mutations have been developed that may also prove useful in evaluating the role of specific receptors in mediating the actions of drugs. We were inte...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-002-1252-6

    authors: Smith RL,Barrett RJ,Sanders-Bush E

    更新日期:2003-02-01 00:00:00

  • Acute fluoxetine treatment potentiates amphetamine hyperactivity and amphetamine-induced nucleus accumbens dopamine release: possible pharmacokinetic interaction.

    abstract::Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050852

    authors: Sills TL,Greenshaw AJ,Baker GB,Fletcher PJ

    更新日期:1999-02-01 00:00:00

  • Response to selection for ethanol-induced locomotor activation: genetic analyses and selection response characterization.

    abstract::Selectively bred FAST mice are highly susceptible, while SLOW mice are less susceptible, to the locomotor stimulant effects of ethanol. Heritability estimates indicate that approximately 15% of the variance in the FAST lines is of additive genetic origin, while low susceptibility is ostensibly nonheritable. Inbreeding...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244259

    authors: Phillips TJ,Burkhart-Kasch S,Terdal ES,Crabbe JC

    更新日期:1991-01-01 00:00:00

  • Effect of subcutaneous nicotine injections of EEG alpha frequency in non-smokers: a placebo-controlled pilot study.

    abstract::The effect of two subcutaneous injections of 0.6 mg nicotine, administered 40 min apart, was compared with placebo in four non-smoking subjects in a counter-balanced double-blind crossover design. The nicotine injections produced mean peak plasma nicotine concentrations of 5.3 ng/ml 10 min after the first injection an...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02244767

    authors: Foulds J,McSorley K,Sneddon J,Feyerabend C,Jarvis MJ,Russell MA

    更新日期:1994-06-01 00:00:00

  • Suppression of cocaine self-administration in monkeys: effects of delayed punishment.

    abstract:RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-011-2501-3

    authors: Woolverton WL,Freeman KB,Myerson J,Green L

    更新日期:2012-04-01 00:00:00

  • Separate and combined effects of marijuana and alcohol on mood, equilibrium and simulated driving.

    abstract:RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00213-002-1124-0

    authors: Liguori A,Gatto CP,Jarrett DB

    更新日期:2002-10-01 00:00:00

  • Post-retrieval oxytocin facilitates next day extinction of threat memory in humans.

    abstract:RATIONALE:Memories can return to a labile state and become amenable to modification by pharmacological and behavioral manipulations after retrieval. This process may reduce the impact of aversive memories and provide a promising therapeutic technique for the treatment of anxiety disorders. A growing body of evidence su...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-018-5074-6

    authors: Hu J,Wang Z,Feng X,Long C,Schiller D

    更新日期:2019-01-01 00:00:00

  • Individual and morphological differences in the behavioural response to apomorphine in rats.

    abstract::The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00172869

    authors: Havemann U,Magnus B,Möller HG,Kuschinsky K

    更新日期:1986-01-01 00:00:00

  • Behavioral processes underlying the intake suppressive effects of melanocortin 3/4 receptor activation in the rat.

    abstract:RATIONALE:Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated. OBJECTIVES:We examined the ingestive behavioral effects of MTII at the microstructural level using two complementary approaches. METHODS...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-002-1022-5

    authors: Williams DL,Grill HJ,Weiss SM,Baird JP,Kaplan JM

    更新日期:2002-04-01 00:00:00

  • Intra-amygdala injections of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in rats.

    abstract::The effects of intra-amygdala injections of corticotropin-releasing factor (CRF) on memory and exploratory behavior in rats were examined in the present study. Rats with chronically implanted cannulae received intra-amygdala injections of vehicle or CRF at a dose of 0.01, 0.1 or 1.0 micrograms, either immediately afte...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00177566

    authors: Liang KC,Lee EH

    更新日期:1988-01-01 00:00:00

  • Cognitive-impairing effects of medroxyprogesterone acetate in the rat: independent and interactive effects across time.

    abstract:RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-011-2322-4

    authors: Braden BB,Garcia AN,Mennenga SE,Prokai L,Villa SR,Acosta JI,Lefort N,Simard AR,Bimonte-Nelson HA

    更新日期:2011-11-01 00:00:00

  • Perphenazine decanoate and cis(z)-flupentixol decanoate in maintenance treatment of schizophrenic outpatients. Serum levels at the minimum effective dose.

    abstract::Two groups of schizophrenic outpatients were treated with perphenazine decanoate (N = 20) and cis(z)-flupentixol decanoate (N = 24) respectively. Every 3 months the dose was gradually reduced until symptoms appeared that were suggestive of a prodromal phase of a psychotic episode. A slightly higher dose was then promp...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02316862

    authors: Kistrup K,Gerlach J,Aaes-Jørgensen T,Larsen NE

    更新日期:1991-01-01 00:00:00

  • The effects of chronic buprenorphine on intake of heroin and cocaine in rats and its effects on nucleus accumbens dopamine levels during self-administration.

    abstract:RATIONALE:Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear. OBJECTIVES:To determine the effects of chronic buprenorphine treatment on intake of heroin and/or cocaine and measure nucleus accumbens (NAc) dopamine (DA) levels during self-administration. METHODS:In...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0485-1

    authors: Sorge RE,Stewart J

    更新日期:2006-09-01 00:00:00

  • Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine.

    abstract:RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05558-0

    authors: McClenahan SJ,Gunnell MG,Owens SM,Fantegrossi WE

    更新日期:2020-09-01 00:00:00

  • Effect of topiramate treatment on ethanol consumption in rats.

    abstract:RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-009-1683-4

    authors: Breslin FJ,Johnson BA,Lynch WJ

    更新日期:2010-01-01 00:00:00

  • Injections of muscimol into the median raphe nucleus produce hippocampal theta rhythm in the urethane anesthetized rat.

    abstract::It has previously been shown that serotonergic [5-hydroxytryptamine (5-HT)] neurons of the median raphe nucleus (MR) are critically involved in the control of the hippocampal electroencephalogram (EEG). Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hi...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02311170

    authors: Kinney GG,Kocsis B,Vertes RP

    更新日期:1995-08-01 00:00:00

  • Evidence for cell loss in corpus striatum after long-term treatment with a neuroleptic drug (flupenithixol) in rats.

    abstract::The number of nerve cells in two different areas of the corpus striatum (i.e., ventrolateral and dorsomedial) was estimated in rat brain after long-term (36 weeks) treatment with the neuroleptic flupenthixol. Nine rats were given weekly injections of 4 mg/kg flupenthixol dissolved in Viscoleo i.m., and seven rats rece...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00428036

    authors: Nielsen EB,Lyon M

    更新日期:1978-09-15 00:00:00

  • Failure of muscarinic blockade to antagonize analepsis induced by thyrotropin-releasing hormone and MK-771 in the rat.

    abstract::In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00431749

    authors: Santori EM,Schmidt DE,Kalivas PW,Horita A

    更新日期:1981-01-01 00:00:00