Abstract:
:Diazepam-sensitive (DS) and -resistant (DR) mice were selectively bred for increased and reduced sensitivity to the ataxic effects of diazepam (40 mg/kg). Other response differences between DS and DR mice may reflect pleiotropic effects of the genes fixed during their selection. These mice were tested for their sensitivity to the locomotor stimulant effects of several doses of diazepam, flunitrazepam, pentobarbital, phenobarbital, and ethanol. DR mice were more sensitive than DS mice to the locomotor stimulant effects of all drugs except phenobarbital. These results largely support the hypothesis that a common biological mechanism mediates sensitivity to the stimulant effects of sedative-hypnotic drugs. Receptor mediation of the benzodiazepine effects was examined by administering the benzodiazepine receptor antagonist, RO15-1788. Locomotor depression produced by diazepam and flunitrazepam in DS mice was blocked by RO15-1788. However, while the locomotor stimulation produced by diazepam in DR mice was antagonized, the stimulant effect of flunitrazepam was not. This suggests that binding of flunitrazepam to the GABAA-benzodiazepine receptor is not necessary for production of locomotor stimulation.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Phillips TJ,Gallaher EJdoi
10.1007/BF02244976subject
Has Abstractpub_date
1992-01-01 00:00:00pages
125-31issue
1eissn
0033-3158issn
1432-2072journal_volume
107pub_type
杂志文章abstract:RATIONALE:The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD therapy. OBJECTIVES:We i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4133-5
更新日期:2016-02-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1995-02-01 00:00:00
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更新日期:2002-12-01 00:00:00
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1978-10-31 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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更新日期:2009-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428198
更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181242
更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05639-0
更新日期:2020-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2674-4
更新日期:2012-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246263
更新日期:1995-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246300
更新日期:1995-06-01 00:00:00
abstract:RATIONALE:Despite the high prevalence of nicotine use in humans, robust nicotine self-administration has been difficult to demonstrate in laboratory animals. OBJECTIVES:A parametric analysis of nicotine self-administration was conducted to study its reinforcing effects in nonhuman primates. METHODS:Adult rhesus macaq...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4293-y
更新日期:2016-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-006-0622-x
更新日期:2007-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4913-9
更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2006-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02180028
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00652236
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0176-3
更新日期:2006-01-01 00:00:00
abstract:RATIONALE:Preclinical studies suggest that medications enhancing the brain gamma amino butyric acid (GABA) system attenuate the rewarding effects of stimulants including nicotine. These preclinical studies have not been followed up in systematic human studies. OBJECTIVES:This study was conducted to examine the effects...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0010-y
更新日期:2005-09-01 00:00:00
abstract::Nicotine (6 mg/kg/day) was administered subcutaneously via Alzet osmotic pumps to rats for 28 days. Nociception was measured by the hot-plate and tail-flick methods. A significant antinociceptive effect was demonstrated during the first week of the treatment; after that tolerance developed, lasting for the remaining p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245428
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1180-1
更新日期:2008-10-01 00:00:00
abstract:RATIONALE:The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth. OBJECTIVES:This review describes the existing published and unpublished literat...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0442-z
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants, particularly cocaine use during "binges." OBJECTIVE:Experimental protocols were designed to induce behavioral sensitization through exposures to social-defeat stress...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100858
更新日期:2001-12-01 00:00:00