Changes in morphine self-administration after tel-diencephalic lesions in rats.

abstract：:It has been suggested that the GAbAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We rep...

journal_title：Psychopharmacology

authors： Taha EB,Dean P,Redgrave P

更新日期：1982-01-01 00:00:00

abstract：:The peripheral BDZ receptor ligand Ro 5-4864 was administered to rabbits in doses ranging from 0.2 to 7 mg/kg IV. Changes in electrocortical activity appeared within 1 min after administration, characterized by trains of slow waves in the posterior sensorimotor and optic cortices (0.6-2 mg/kg) and by grand mal seizure...

journal_title：Psychopharmacology

authors： Massotti M,Lucantoni D

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:The integrity of cortical cholinergic transmission is vital to attentional processing. A growing literature suggests that alterations in attentional processing accompany addictive drug use. This study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. OBJ...

journal_title：Psychopharmacology

authors： Arnold HM,Nelson CL,Sarter M,Bruno JP

更新日期：2003-02-01 00:00:00

abstract：RATIONALE:Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants, particularly cocaine use during "binges." OBJECTIVE:Experimental protocols were designed to induce behavioral sensitization through exposures to social-defeat stress...

journal_title：Psychopharmacology

authors： Covington HE 3rd,Miczek KA

更新日期：2001-12-01 00:00:00

abstract：:The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...

journal_title：Psychopharmacology

authors： de Leeuw AS,Den Boer JA,Slaap BR,Westenberg HG

更新日期：1996-08-01 00:00:00

abstract：:Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during treatment, the complicated metabolism of CPZ, or to varying degrees of protein binding. Using a mass fragmentographic ...

journal_title：Psychopharmacology

authors： Wode-Helgodt B,Alfredsson G

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Nitric oxide (NO) is a messenger synthesized in both the neuronal and glial populations by nitric oxide synthase type 1 (NOS1). Nicotine regulates NO production in a sex-dependent manner, both molecules being involved in motor function. OBJECTIVE:The present study evaluates sex differences in motor coordinat...

journal_title：Psychopharmacology

authors： Muñoz-Castañeda R,Díaz D,Avila-Zarza CA,Alonso JR,Weruaga E

更新日期：2014-02-01 00:00:00

abstract：:Latent inhibition (LI) is a phenomenon in which repeated, non-reinforced presentation of a stimulus retards subsequent conditioning to that stimulus. Several recent experiments have suggested that LI is abolished following acute, low doses of amphetamine given during pre-exposure and conditioning, and this effect has ...

journal_title：Psychopharmacology

authors： Killcross AS,Robbins TW

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:In drug-dependent individuals, the primary excessive motivation is for drugs. Studies also indicate altered interest for "natural" rewarding activities associated with motivational disorders that may be relevant to drug dependence. However, to date, the impact of drug dependence and withdrawal upon motivation...

journal_title：Psychopharmacology

authors： Rouibi K,Contarino A

更新日期：2012-06-01 00:00:00

abstract：:The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxy...

journal_title：Psychopharmacology

authors： Pickar D,Cohen RM,Jimerson DC,Lake CR,Murphy DL

更新日期：1981-01-01 00:00:00

abstract：:In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-...

journal_title：Psychopharmacology

authors： Herbert M,Standen PJ,Short AH,Birmingham AT

更新日期：1983-01-01 00:00:00

abstract：:Dosage regimen adjustments because of poor renal function are often assumed to be unnecessary for extensively metabolized antidepressants. This assumption is being increasingly questioned in recognition of the role of active drug metabolites. The purpose of this study was to assess the steady-state accumulation of the...

journal_title：Psychopharmacology

authors： DeVane CL,Laizure SC,Cameron DF

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...

journal_title：Psychopharmacology

authors： Deschaux O,Spennato G,Moreau JL,Garcia R

更新日期：2011-05-01 00:00:00

abstract：RATIONALE:Demonstrations of associative tolerance to the analgesic effects of morphine, not confounded by practice or novelty effects, have been restricted to the tail-flick and flinch-jump tests. OBJECTIVES:Experiment 1 investigated whether associative tolerance would be found on two other nociceptive assessment meth...

journal_title：Psychopharmacology

authors： Cepeda-Benito A,Tiffany ST,Cox LS

更新日期：1999-08-01 00:00:00

abstract：RATIONALE:Trichotillomania is characterized by repetitive pulling causing noticeable hair loss. Pharmacological treatment data for trichotillomania are limited. OBJECTIVE:Dronabinol appears to reduce the exocitotoxic damage caused by glutamate release in the striatum and offers promise in reducing compulsive behavior....

journal_title：Psychopharmacology

authors： Grant JE,Odlaug BL,Chamberlain SR,Kim SW

更新日期：2011-12-01 00:00:00

abstract：:Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse e...

journal_title：Psychopharmacology

authors： Yisak W,Farde L,von Bahr C,Nilsson LB,Fredriksson G,Ogenstad S

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced. OBJECTIVES:We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produ...

journal_title：Psychopharmacology

authors： Thiel KJ,Sanabria F,Neisewander JL

更新日期：2009-06-01 00:00:00

abstract：RATIONALE:Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are components of the mechanism that mediates the overall effects of nic...

journal_title：Psychopharmacology

authors： Rezvani AH,Cauley M,Xiao Y,Kellar KJ,Levin ED

更新日期：2013-03-01 00:00:00

abstract：:The effects of benzodiazepine (triazolam 0.25 and 0.50 mg) on different aspects of cognitive function were assessed. Triazolam impaired free recall and recognition of information presented after drug administration. In contrast to these impairments in explicit memory, a memory function that did not require conscious a...

journal_title：Psychopharmacology

authors： Weingartner HJ,Hommer D,Lister RG,Thompson K,Wolkowitz O

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophre...

journal_title：Psychopharmacology

authors： Pouget P,Wattiez N,Rivaud-Péchoux S,Gaymard B

更新日期：2010-05-01 00:00:00

abstract：:The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...

journal_title：Psychopharmacology

authors： Rowlett JK,Woolverton WL

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:The cholinergic system is linked extensively to memory, but its exact role remains controversial. In particular, scopolamine-induced impairment in rodents is not task specific, which may be due to difficulty in developing rodent protocols to assess deficits in recent memory, in which the remembered event is b...

journal_title：Psychopharmacology

authors： Araujo JA,Chan AD,Winka LL,Seymour PA,Milgram NW

更新日期：2004-08-01 00:00:00

abstract：:In order to assess the contribution of cerebellar effects of ethanol to the production of ataxia, "nervous" (nr/nr) and control (nr/+ or +/+) C3H mice were tested for locomotor ability 2 min after being given intraperitoneal ethanol injections. The nr/nr mice suffer from loss of most of their cerebellar Purkinje cells...

journal_title：Psychopharmacology

authors： Northup LR

更新日期：1976-07-28 00:00:00

abstract：:The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...

journal_title：Psychopharmacology

authors： Nurnberger JI Jr,Simmons-Alling S,Kessler L,Jimerson S,Schreiber J,Hollander E,Tamminga CA,Nadi NS,Goldstein DS,Gershon ES

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving--though long suspected--remains elusive. MATERIALS AND METHODS:We employed laboratory exposure to stress, alcohol cue, and neu...

journal_title：Psychopharmacology

authors： Mangieri RA,Hong KI,Piomelli D,Sinha R

更新日期：2009-07-01 00:00:00

abstract：:There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sit...

journal_title：Psychopharmacology

authors： Benmansour S,Tejani-Butt SM,Hauptmann M,Brunswick DJ

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Toluene is a misused inhalant with hallucinogenic properties and complex effects. Toluene blocks N-methyl-D-aspartate (NMDA) receptors, releases dopamine (DA), and modifies several neurotransmitter levels; nonetheless, the mechanism by which it produces hallucinations is not well characterized. OBJECTIVES:Th...

journal_title：Psychopharmacology

authors： Rivera-García MT,López-Rubalcava C,Cruz SL

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:Though interoceptive properties of antidepressants have been described, discriminative stimulus (DS) properties of mirtazapine, which does not affect monoamine reuptake, remain uncharacterized. OBJECTIVES:The objectives of the study are to train rats to recognize a mirtazapine DS, then perform substitution s...

journal_title：Psychopharmacology

authors： Dekeyne A,Millan MJ

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Robust intravenous (i.v.) nicotine self-administration (SA) in rats has been reported by several laboratories, including our own, using fixed ratio (FR) schedules of reinforcement. Studies on other drugs of abuse, however, suggest that progressive ratio (PR) schedules may provide additional information not ga...

journal_title：Psychopharmacology

authors： Donny EC,Caggiula AR,Mielke MM,Booth S,Gharib MA,Hoffman A,Maldovan V,Shupenko C,McCallum SE

更新日期：1999-11-01 00:00:00

abstract：:Rats that are placed in a novel environment containing a probe will explore the environment and the probe. Exploration of the probe is reduced when the probe is electrified. We here report that chlordiazepoxide blocks this inhibition, and have determined some of the pharmacological features of this new experimental pr...

journal_title：Psychopharmacology

authors： Meert TF,Colpaert FC

更新日期：1986-01-01 00:00:00