Abstract：
RATIONALE:Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced. OBJECTIVES:We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produce an enhanced conditioned place preference (CPP) relative to either reward given alone. The present study further examined the nature of drug-social reward interactions using nicotine. METHODS:Dose-effect functions for nicotine-CPP were established using two different routes of administration (vehicle, 0.1, 0.3, and 0.6 mg/kg, SC and vehicle, 0.01, 0.03, and 0.06 mg/kg, IV). The effects of nicotine on social reward-CPP and social play behavior were next examined using parameters presumed to be sub-threshold for establishing social reward- and nicotine-CPP. RESULTS:Dose-dependent nicotine-CPP was observed using both routes of administration. Two pairings of the initially non-preferred side of the apparatus with either SC nicotine or another adolescent rat failed to produce CPP when examined alone, but together produced a robust CPP despite nicotine reducing social play. This interaction effect was not observed with the IV nicotine. A final experiment demonstrated that the enhancement of CPP with the combination of rewards was not due to additive effects of weak, sub-threshold conditioning. CONCLUSIONS:These findings suggest that nicotine and social rewards interact synergistically in adolescent rats resulting in a greater, perhaps qualitatively different, reward than either reward given alone. Understanding drug-social reward interactions may provide new directions for development of preventions and interventions of adolescent smoking.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Thiel KJ,Sanabria F,Neisewander JLdoi
10.1007/s00213-009-1470-2subject
Has Abstractpub_date
2009-06-01 00:00:00pages
391-402issue
3eissn
0033-3158issn
1432-2072journal_volume
204pub_type
杂志文章abstract：RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the disc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1238-0
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abstract：:This was a 4-week, three-center, double-blind, randomized, parallel, placebo-controlled evaluation of the efficacy and safety of bupropion in hospitalized depressed patients. Results from 27 placebo and 48 bupropion-treated patients were analyzed for efficacy and safety. Assessments of efficacy and safety were made at...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：RATIONALE:The effects of caffeine, especially caffeinated coffee, on human performance have been extensively studied. However, few studies have been naturalistic representations of how tea/coffee is normally consumed in terms of dose and time of consumption. OBJECTIVES:This study investigated the effects of day-long c...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130000383
更新日期：2000-04-01 00:00:00
abstract：:Effects of two dosages of rubidium chloride on exploration, locomotion, rearing and immobility were assessed for male and female rats in an exploration box and an open field. In contrast to previous findings, rubidium was found to decrease locomotion and rearing in the exploratory box, and also to decrease locomotion ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426740
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journal_title：Psychopharmacology
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doi：10.1007/s00213-006-0673-z
更新日期：2007-05-01 00:00:00
abstract：RATIONALE:(+/-) 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine analog and drug of abuse. In animals, MDMA damages brain serotonin (5-HT) neurons at doses that overlap with those used recreationally by some humans. To date, few functional sequelae of MDMA-induced 5-HT damage have been identified. ...
journal_title：Psychopharmacology
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doi：10.1007/s002130050967
更新日期：1999-04-01 00:00:00
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更新日期：2002-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2012-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00436101
更新日期：1982-01-01 00:00:00
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journal_title：Psychopharmacology
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更新日期：2012-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00178516
更新日期：1986-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1913-9
更新日期：2010-09-01 00:00:00
abstract：:Neuroimaging has been identified as a potentially powerful probe for the in vivo study of drug effects on the brain with utility across several phases of drug development spanning preclinical and clinical investigations. Specifically, neuroimaging can provide insight into drug penetration and distribution, target enga...
journal_title：Psychopharmacology
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doi：10.1007/s00213-007-0900-2
更新日期：2008-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-003-1532-9
更新日期：2003-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00652245
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
pub_type： 杂志文章
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051093
更新日期：1999-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051029
更新日期：1999-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2009-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0256-4
更新日期：2007-01-01 00:00:00
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journal_title：Psychopharmacology
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更新日期：2009-08-01 00:00:00
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journal_title：Psychopharmacology
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doi：10.1007/s00213-010-2039-9
更新日期：2011-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...
journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
