Abstract:
:During the third week of life, a hyperactive period for laboratory rat, the occurrence of 8 behavioral categories was recorded in individual littermates transferred to a novel environment. Neonatal destruction of the catecholaminergic system by intraventricular injection of 6-OH-DA resulted in increased motor activity during the third week of life. Selective lesioning of the dopaminergic system by the combined treatment of 6-OH-DA + desmethylimipramine also induced a significant increase in some active behavioral categories. It appeared that in contrasts to the gross behavioral sequence, as seen in controls, which compromised locomotion and rearing leads to grooming leads to sitting and lying down, the lesioned animals showed a prolonged phse of restless locomotion. These data are interpreted as a disability to habituate adequately to a novel environment after neonatal lesioning of the dopaminergic system.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Stoof JC,Duijkstra H,Hillegers JPdoi
10.1007/BF00426882subject
Has Abstractpub_date
1978-04-28 00:00:00pages
163-6issue
2eissn
0033-3158issn
1432-2072journal_volume
57pub_type
杂志文章abstract:OBJECTIVE:The aim of our study was to test whether ketamine produces an antidepressant effect in animal model of olfactory bulbectomy and assess the role of mammalian target of rapamycin (mTOR) pathway in ketamine's antidepressant effect. METHODS:Bulbectomized (OBX) rats and sham controls were assigned to four subgrou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4256-3
更新日期:2016-06-01 00:00:00
abstract::Human eyeblink conditioning, a relatively simple form of learning and memory, has previously been shown to be impaired by the central and peripheral anticholinergic scopolamine. The present study compared the behavioral effects of scopolamine with the benzodiazepine lorazepam and a peripherally active anticholinergic,...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246273
更新日期:1995-12-01 00:00:00
abstract::The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445554
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Evidence that alcohol leads to increased aggressive behaviour is equivocal and confounded by evidence that such effects may operate indirectly via expectancy. One mechanism by which alcohol consumption may increase aggressive behaviour is via alterations in the processing of emotional facial cues. OBJECTIVES...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1463-1
更新日期:2009-06-01 00:00:00
abstract::Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245309
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Major depression is a chronic disabling disorder, often preceded by stress. Despite emerging clinical interest in mechanisms perpetuating episodes of depression and/or establishing increased vulnerability for relapse, little attention has been paid to address these aspects in experimental models. Here, we stu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1835-6
更新日期:2010-06-01 00:00:00
abstract:RATIONALE:Impulsivity is related to greater risk of nicotine dependence, perhaps by enhancing sensitivity to nicotine's reinforcing and rewarding effects during initial smoking experiences. OBJECTIVE:We examined the influence of impulsivity characteristics on acute sensitivity to nicotine reward, reinforcement, and ot...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1231-7
更新日期:2008-11-01 00:00:00
abstract:RATIONALE:The Scheduled High Alcohol Consumption (SHAC) binge drinking model is a simple, partial murine model with which to investigate some of the neurobiological underpinnings of alcoholism. OBJECTIVES:The SHAC model was used to characterize monoamine and amino acid adaptations produced in the nucleus accumbens (NA...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0641-7
更新日期:2007-03-01 00:00:00
abstract::The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00432251
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05462-7
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Although ethanol is frequently used in combination with other psychoactive drugs, the behavioral and pharmacological reasons for this form of polydrug abuse have not been well described. MATERIALS AND METHODS:Rhesus monkeys with indwelling intravenous catheters produced intravenous injections of ethanol (50...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0809-9
更新日期:2007-09-01 00:00:00
abstract:RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-008-1216-6
更新日期:2009-01-01 00:00:00
abstract:RATIONALE:Depressed patients robustly exhibit affective biases in emotional processing which are altered by SSRIs and predict clinical outcome. OBJECTIVES:The objective of this study is to investigate whether psilocybin, recently shown to rapidly improve mood in treatment-resistant depression (TRD), alters patients' e...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4754-y
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3833-6
更新日期:2015-06-01 00:00:00
abstract:RATIONALE:Demonstrations of associative tolerance to the analgesic effects of morphine, not confounded by practice or novelty effects, have been restricted to the tail-flick and flinch-jump tests. OBJECTIVES:Experiment 1 investigated whether associative tolerance would be found on two other nociceptive assessment meth...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051077
更新日期:1999-08-01 00:00:00
abstract:RATIONALE:Although some aspects of memory functions are known to be acutely impaired by delta(9)-tetrahydrocannabinol (delta(9)-THC; the main active constituent of marijuana), effects on other aspects of memory are not known and the time course of functional impairments is unclear. OBJECTIVE:The present study aimed to...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-002-1169-0
更新日期:2002-10-01 00:00:00
abstract::The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050648
更新日期:1998-07-01 00:00:00
abstract:RATIONALE:The notion that the onset of action of antidepressant drugs (ADs) takes weeks is widely accepted; however, the sequence of events necessary for therapeutic effects still remains obscure. OBJECTIVE:We aimed to evaluate a time-course of ADs-induced alterations in the expression of 95 selected genes in 4 region...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2714-0
更新日期:2012-10-01 00:00:00
abstract::Rats were trained to self-administer cocaine in 1-h sessions on a fixed ratio 5 (FR5) schedule of reinforcement. Acquisition was carried out at a unit dose of 0.3 mg/kg and responding was then stabilized at cocaine doses of 0.1, 0.3, and 1.0 mg/kg/infusion. Pretreatments with naltrexone (0.1-10 mg/kg, SC) 20 min prior...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244173
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Evidences indicate that methylglyoxal, a highly reactive metabolite of hyperglycemia, can enhance protein glycation, oxidative stress, or inflammation. Mangiferin, a polyphenol compound of C-glucoside, has many beneficial biological activities, including anti-inflammation, anti-oxidation, neuroprotection, cog...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3061-5
更新日期:2013-08-01 00:00:00
abstract:RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2082-6
更新日期:2011-04-01 00:00:00
abstract::In mice that were scored for the length of time they remained immobile in awkward postures (cataleptic) on an inclined wire grid, a large IP dose of pilocarpine (80 mg/kg) caused a clear catalepsy, which was prevented by both dopamine agonists that were tested, apomorphine (4 or 8 mg/kg, IP) and bromocriptine (8 mg/kg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431769
更新日期:1985-01-01 00:00:00
abstract::Administration to mice of harmaline (100 mg/kg SC) resulted in a greater than two-fold increase in cyclic GMP in the cerebellum 15 min later. This response was inhibited by pretreatment 5 min before the harmaline with pentobarbital (ED50 6.5 mg/kg), chlormethiazole (ED50 10.4 mg/kg) and dizocilpine (ED50 0.5 mg/kg). H...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02257413
更新日期:1993-01-01 00:00:00
abstract::In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244140
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Alcohol-associated cues elicit craving in human addicts but little is known about craving mechanisms. Current animal models focus on relapse and this may confound the effect of environmental cues. OBJECTIVES. To develop a model to study the effects of environmental cues on alcohol consumption in animals not e...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1454-6
更新日期:2003-07-01 00:00:00
abstract::Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245832
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Marijuana intoxication appears to impair response inhibition, but it is unclear if impaired inhibition and associated brain abnormalities persist after prolonged abstinence among adolescent users. We hypothesized that brain activation during a go/no-go task would show persistent abnormalities in adolescent m...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0823-y
更新日期:2007-10-01 00:00:00
abstract:RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-002-1326-5
更新日期:2003-09-01 00:00:00
abstract:RATIONALE:The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidep...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1381-7
更新日期:2009-03-01 00:00:00
abstract:RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5068-4
更新日期:2019-01-01 00:00:00