Abstract:
RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the discriminative stimulus effect of LSD at two pretreatment times and 2,5-dimethoxy-4-iodoamphetamine (DOI), a selective 5-HT(2A/2C) agonist. MATERIALS AND METHODS:Male Sprague-Dawley rats were trained in a two-lever, fixed ratio (FR) 50, food-reinforced task with LSD-30 (0.08 mg/kg, i.p., 30-min pretreatment time), LSD-90 (0.16 mg/kg, i.p., 90-min pretreatment time), and DOI (0.4 mg/kg, i.p., 30-min pretreatment time) as discriminative stimuli. Substitution and combination tests with the dopamine D(4) agonists, ABT-724 and WAY 100635, were performed in all groups. Combination tests were run using the dopamine D(4) antagonists A-381393 and L-745,870 and two antipsychotic drugs, clozapine and olanzapine. RESULTS:WAY 100635 produced full substitution in LSD-90 rats, partial substitution in LSD-30 rats, and saline appropriate responding in DOI-trained rats. ABT-724 partially mimicked the LSD-90 and LSD-30 cues, but produced no substitution in DOI-trained rats. In combination tests, both agonists shifted the dose-response curve of LSD leftward, most potently for the LSD-90 cue. The D(4) antagonists significantly attenuated both the LSD-90 and LSD-30 cue, but had no effect on the DOI cue. CONCLUSION:Dopamine D(4) receptor activation plays a significant modulatory role in the discriminative stimulus effects in LSD-90-trained rats, most markedly for the later temporal phase of LSD, but has no effect on the cue produced by DOI.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Marona-Lewicka D,Chemel BR,Nichols DEdoi
10.1007/s00213-008-1238-0subject
Has Abstractpub_date
2009-04-01 00:00:00pages
265-77issue
2eissn
0033-3158issn
1432-2072journal_volume
203pub_type
杂志文章abstract:RATIONALE:The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards. OBJECTIVES:Experiment 1 investigated whet...
journal_title:Psychopharmacology
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doi:10.1007/s00213-010-1779-x
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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abstract:RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00428312
更新日期:1979-01-01 00:00:00
abstract::The pharmacokinetic and pharmacodynamic effects of concomitant administration of alprazolam and fluoxetine were studied in this double-blind parallel study in 80 healthy, male volunteers. Subjects were randomly assigned to one of four treatment groups. Drug treatments consisted of 4-day regimens of 1 mg alprazolam fou...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Central dopaminergic transmission has been implicated in memory processes. The present experiments examined the effects of several direct acting dopaminergic agents on performance of a delayed-non-match-to-sample radial arm maze task. Preadministration of apomorphine (D1-D2 agonist; 0.25, 0.5, and 1.0 mg/kg), quinpiro...
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pub_type: 杂志文章
doi:10.1007/BF02245288
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0275-1
更新日期:2006-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
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更新日期:2005-12-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2014-01-01 00:00:00
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doi:10.1007/BF00427276
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pub_type: 杂志文章
doi:10.1007/BF00449124
更新日期:1982-01-01 00:00:00
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doi:10.1007/s00213-015-4019-6
更新日期:2015-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3038-4
更新日期:2013-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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更新日期:2020-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2021-01-06 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1979-02-28 00:00:00
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更新日期:2019-04-01 00:00:00
abstract:RATIONALE:Schedule-induced polydipsia (SIP) is an established model for studying compulsive behaviour in rats. Serotoninergic drugs effectively reduce compulsive drinking on SIP, and high compulsive drinker rats selected by SIP have shown differences in serotoninergic brain activity. However, the specific serotoninergi...
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更新日期:2015-02-01 00:00:00