Abstract:
:The effect of postethanol treatment with L-Dopa, aminophylline and/or ephedrine was investigated. In one experiment, healthy, male, moderate drinkers ingested ethanol (0.8 g/kg) and then either L-Dopa (1.5 g), or placebo. In a second experiment, subjects ingested ethanol followed by aminophylline (200 mg), ephedrine (50 mg), aminophylline (200 mg) plus ephedrine (50 mg), or placebo. Double-blind, within-subjects, crossover designs were employed. Treatment with L-Dopa significantly reduced ethanol's effect on the electroencephalogram, motor coordination, and divided attention performance (t-test for paired data). Treatment with aminophylline and/or ephedrine also significantly reduced ethanol's effects on the electroencephalogram and motor coordination. The ethanol-antagonism may result from central noradrenergic stimulation.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Alkana RL,Parker ES,Cohen HB,Birch H,Noble EPdoi
10.1007/BF00497849subject
Has Abstractpub_date
1977-12-28 00:00:00pages
203-12issue
3eissn
0033-3158issn
1432-2072journal_volume
55pub_type
临床试验,杂志文章,随机对照试验abstract:RATIONALE:The ability of tobacco harm reduction strategies to produce significant reductions in toxin exposure is limited by compensatory increases in smoking behavior. Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon and assessing ...
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