Abstract:
:Chlordiazepoxide (CDP) and amphetamine (AMPH) were tested, alone or in combination, in BALB/c mice pretreated with alpha-methyl-p-tyrosine (AMT) and subjected to shuttle-box avoidance training. CDP and AMPH, given alone, partly reversed avoidance depression induced by 50 mg/kg of AMT, but were ineffective in mice pretreated with 100 mg/kg of AMT. Stronger effects were produced by CDP-AMPH combinations, which also improved avoidance performance in mice pretreated with the higher dose of AMT. The results suggest that catecholamines may play a role in the facilitation of avoidance induced by CDP, especially when given in combination with AMPH.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Sansone M,Renzi Pdoi
10.1007/BF00433495subject
Has Abstractpub_date
1981-01-01 00:00:00pages
22-4issue
1eissn
0033-3158issn
1432-2072journal_volume
75pub_type
杂志文章abstract::Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00426799
更新日期:1978-06-15 00:00:00
abstract:INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-009-1533-4
更新日期:2009-08-01 00:00:00
abstract:RATIONALE:Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of cocaine, and evidence is accumulating that correlates repetitive administration of sub-convulsive doses of cocaine with a decreased seizure threshold, a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050027
更新日期:2000-01-01 00:00:00
abstract:RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-006-0588-8
更新日期:2006-12-01 00:00:00
abstract::A total of 97 patients, who participated in two studies on the relationship between the clinical effect and plasma levels of imipramine and clomipramine, were examined for improvement curves by use of weekly ratings on the Hamilton Depression Scale (HDS). Although we confirmed that our six-item HDS subscale, in contra...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427459
更新日期:1984-01-01 00:00:00
abstract::Administration of various doses of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) to rats produced dose-related decreases in 1-h food intake in the food-deprived paradigm. Pretreatment with spiperone (5-HT1A/5-HT2/D2 antagonist), propranolol or CGP361A (beta-adrenoceptor antagonists that also have binding affinit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247721
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:The effect of LSD in humans has been described as occurring in two temporal phases. The behavioral effects in rats also occur in two temporal phases: an initial suppression of exploration followed by increased locomotor activity. OBJECTIVES:We decided to investigate this phenomenon from the perspective that ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2183-9
更新日期:2005-07-01 00:00:00
abstract:RATIONALE:Severe, traumatic stress or repeated exposure to stress can result in long-term deleterious effects, including hippocampal cell atrophy and death, which, in turn, result in memory impairments and behavioural abnormalities. The dopaminergic D(2) receptor agonist, bromocriptine, has been shown to modulate learn...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0801-4
更新日期:2007-08-01 00:00:00
abstract::Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism would affect antic...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05515-x
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The general premise that receptor theory provides a useful framework for understanding the behavioral effects of psychoactive drugs has been a central tenet of behavioral pharmacology. OBJECTIVES:The purpose of this review is to reiterate this basic theme and, in particular, the proposition that current con...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130000567
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Alcohol drinking may lead to increased aggression in certain individuals, and both fighting and drinking increase levels of dopamine and serotonin in mesocorticolimbic structures. Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging. OB...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0637-3
更新日期:2007-04-01 00:00:00
abstract::Animal and human studies have demonstrated that, depending upon the sequence of alcohol presentation, long-term memory of events can either be enhanced or diminished. In the present study a similar phenomenon is demonstrated in the neuronal excitability of slices of hippocampus from guinea pig brains. Alcohol given af...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426380
更新日期:1984-01-01 00:00:00
abstract::Recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (SSRIs) in unipolar major depressive disorder. The present study, using the mouse forced swimming test, was performed to investigate further the mechanisms inv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050663
更新日期:1998-07-01 00:00:00
abstract::First, it was confirmed that systemic injection of the neurotoxin 6-hydroxydopamine HBr (30 mg/kg IP) depleted noradrenaline levels in rat heart, but not centrally. Losses averaged 90% of control 1 day after injection, and 50% at 42 days. The same drug and dose was then administered to 50% of a group of rats which had...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431782
更新日期:1985-01-01 00:00:00
abstract::The peripheral BDZ receptor ligand Ro 5-4864 was administered to rabbits in doses ranging from 0.2 to 7 mg/kg IV. Changes in electrocortical activity appeared within 1 min after administration, characterized by trains of slow waves in the posterior sensorimotor and optic cortices (0.6-2 mg/kg) and by grand mal seizure...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00180835
更新日期:1986-01-01 00:00:00
abstract::Roxindole is a potent autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-HT1A agonist. In order to get more insight into its mode of action in various psychiatric populations, we evaluated the effects of subchronic roxindole treatment on pituitary and adrenal hor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246221
更新日期:1995-02-01 00:00:00
abstract:RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3816-7
更新日期:2015-05-01 00:00:00
abstract::The relationship between each of two pharmacologic effects (tachycardia and psychological "high") of delta-9-tetrahydrocannabinol (THC) and plasma THC concentration was investigated in three male and three female experienced marihuana smokers. Each subject smoked 1% THC cigarette on two occasions separated by 2 h. Hea...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432179
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:A subset of male rats that self-administer 3,4-methylenedioxypyrovalerone (MDPV) have unusually high levels of drug intake; however, factor(s) that influence this behavior (e.g., reinforcement history and sex) are unknown. OBJECTIVES:Characterize the reinforcing potency and effectiveness of MDPV in female ra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05726-2
更新日期:2020-11-24 00:00:00
abstract::Acute alcohol intoxication disrupts memory acquisition in humans and laboratory animals. This review summarizes recent behavioral and immediate early gene expression studies addressing the mechanisms of this phenomenon. Most behavioral investigations agree that the amnestic effect of alcohol is due to its preferential...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050687
更新日期:1998-09-01 00:00:00
abstract:RATIONALE:Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects. OBJECTIVES:This study examines the effect of the preferential D(3) agonist ropinirole on PPI in humans. METHODS:PPI w...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0843-7
更新日期:2007-10-01 00:00:00
abstract:RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05623-8
更新日期:2020-11-01 00:00:00
abstract::The effects of single and repeated electroconvulsive treatment (ECT) on beta-endorphin (beta-EP), cortisol, growth hormone (GH) and prolactin (Prl) plasma levels were investigated in nine depressed patients. Blood samples were monitored a day before ECT, the day of the first and sixth ECT (0, 30, 60 and 90 min after s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02439598
更新日期:1987-01-01 00:00:00
abstract::We examined the effects on sucrose consumption of a dopamine (DA) D2/D3 antagonist (raclopride, 0-0.3 mg/kg), a serotonin 5-HT2/2c antagonist (ritanserin, 0-0.4 mg/kg), and raclopride (0.15 mg/kg) combined with ritanserin (0-0.4 mg/kg). Three different concentrations of sucrose solution (0.7%, 7.0% and 34%) were teste...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246286
更新日期:1996-01-01 00:00:00
abstract:RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0006-7
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Recent studies using positron emission tomography (PET) have established the relationship between an intravenous dose of cocaine and the percentage occupancy of the dopamine transporter in humans, and have documented the requirement of more than 50% occupancy for perception of the "high". The present experim...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051093
更新日期:1999-09-01 00:00:00
abstract::Adult hooded rats exposed to a repeated maternal separation procedure during the neonatal period showed a blunted expression of locomotor hyperactivity conditioned to the presentation of the daily food ration. We have demonstrated that the expression of food-conditioned anticipatory hyperactivity is sensitive to the r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246414
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this assoc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2643-y
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. MATERIALS AND METHODS:We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0551-8
更新日期:2006-12-01 00:00:00
abstract:RATIONALE:Greater incidence of anxiety and depressive disorders of women compared to men may be due in part to progesterone (P) and its neuroactive metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), acting in limbic regions, such as the amygdala. OBJECTIVE:If P's metabolism via 5alpha-reduction to 3alpha...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0100-x
更新日期:2006-06-01 00:00:00