Relationship between variations in estradiol and progesterone levels across the menstrual cycle and human performance.

Abstract:

RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal phase of the menstrual cycle. METHODS:In a within-subjects design, 24 female pilots were tested twice during their menstrual cycle: once during the menstrual and once during the luteal phase. On both test days they performed a 75-min simulator flight in a Frasca 141, a popular pilot training device. RESULTS:Despite highly significant differences in estradiol (E2) as well as progesterone (P) levels on the 2 test days, and despite excluding subjects with anovulatory cycles from the analyses, there were no significant differences in overall flight performance between the menstrual and luteal phases. We found no significant correlations between E2 or P levels and flight performance. CONCLUSIONS:We found no evidence that the tested menstrual cycle phases and their associated E2 and P levels significantly influence flight simulator performance. We consider these negative findings based on 24 subjects meaningful because previous studies on the influence of menstrual cycle on cognitive performance have not involved complex "real world" tasks such as piloting an aircraft and they obtained inconsistent results.

journal_title

Psychopharmacology

authors

Mumenthaler MS,O'Hara R,Taylor JL,Friedman L,Yesavage JA

doi

10.1007/s002130100700

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

198-203

issue

2

eissn

0033-3158

issn

1432-2072

journal_volume

155

pub_type

杂志文章
  • Platelet membrane fluidity and treatment response in cognitively-impaired, depressed elderly: initial results.

    abstract::A prospective study of response to treatment with nortriptyline was carried out in a group of 14 inpatients with mixed symptoms of depression and dementia. Platelet membrane fluidity, as reflected by the fluorescence anisotropy of DPH labeled membranes, was determined for all 14 drug-free subjects prior to treatment b...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00174688

    authors: Zubenko GS,Reynolds CF 3rd,Perel JM,Decker C,Malinakova I

    更新日期:1988-01-01 00:00:00

  • Glucocorticoid mechanisms may contribute to ECT-induced retrograde amnesia.

    abstract:RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0593-y

    authors: Nagaraja N,Andrade C,Sudha S,Madan Singh N,Chandra JS,Venkataraman BV

    更新日期:2007-01-01 00:00:00

  • Nicotine e-cigarette vapor inhalation effects on nicotine & cotinine plasma levels and somatic withdrawal signs in adult male Wistar rats.

    abstract:RATIONALE:Non-contingent chronic nicotine exposure procedures have evolved rapidly in recent years, culminating in electronic nicotine delivery systems (ENDS or e-cigarettes) to deliver vaporized drugs to rodents in standard housing chambers. OBJECTIVES:The aim of the current work was to use ENDS to test concentration...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05400-2

    authors: Montanari C,Kelley LK,Kerr TM,Cole M,Gilpin NW

    更新日期:2020-03-01 00:00:00

  • A double-blind placebo controlled experimental study of nicotine: I--effects on incentive motivation.

    abstract:RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00213-006-0588-8

    authors: Dawkins L,Powell JH,West R,Powell J,Pickering A

    更新日期:2006-12-01 00:00:00

  • Influence of naloxone upon motor activity induced by psychomotor stimulant drugs.

    abstract::Naloxone, an opioid receptor antagonist, attenuates a wide range of behavioral effects of d-amphetamine, such as the stimulation of motor activity. To investigate the pharmacological selectivity of the naloxone/amphetamine interaction, we assessed the effects of naloxone (5.0 mg/kg SC) upon motor activity induced in r...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244839

    authors: Jones DN,Holtzman SG

    更新日期:1994-03-01 00:00:00

  • Nicotine self-administration in rats on a progressive ratio schedule of reinforcement.

    abstract:RATIONALE:Robust intravenous (i.v.) nicotine self-administration (SA) in rats has been reported by several laboratories, including our own, using fixed ratio (FR) schedules of reinforcement. Studies on other drugs of abuse, however, suggest that progressive ratio (PR) schedules may provide additional information not ga...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130051153

    authors: Donny EC,Caggiula AR,Mielke MM,Booth S,Gharib MA,Hoffman A,Maldovan V,Shupenko C,McCallum SE

    更新日期:1999-11-01 00:00:00

  • Increased accumbal dopamine during daily alcohol consumption and subsequent aggressive behavior in rats.

    abstract:BACKGROUND:Alcohol drinking may lead to increased aggression in certain individuals, and both fighting and drinking increase levels of dopamine and serotonin in mesocorticolimbic structures. Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging. OB...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0637-3

    authors: van Erp AM,Miczek KA

    更新日期:2007-04-01 00:00:00

  • Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated early maternal separation: effects of prefeeding, d-amphetamine, dopamine antagonists and clonidine.

    abstract::Adult hooded rats exposed to a repeated maternal separation procedure during the neonatal period showed a blunted expression of locomotor hyperactivity conditioned to the presentation of the daily food ration. We have demonstrated that the expression of food-conditioned anticipatory hyperactivity is sensitive to the r...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02246414

    authors: Matthews K,Hall FS,Wilkinson LS,Robbins TW

    更新日期:1996-07-01 00:00:00

  • Evidence for behavioral sensitization to cocaine in preweanling rat pups.

    abstract::While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050653

    authors: Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LP

    更新日期:1998-07-01 00:00:00

  • Comparison of anti-conflict drug effects in three experimental animal models of anxiety.

    abstract::A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427112

    authors: Kilts CD,Commissaris RL,Rech RH

    更新日期:1981-01-01 00:00:00

  • Clonidine and diazepam have differential effects on tests of attention and learning.

    abstract::The noradrenergic system has repeatedly been implicated in the mediation of attentional processes. Using a double-blind, placebo-controlled design, the present investigation examines the effects of two doses (1.5 micrograms/kg and 2.5 micrograms/kg) of the alpha 2 adrenoceptor agonist clonidine (CLO) on performance of...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02311180

    authors: Coull JT,Middleton HC,Robbins TW,Sahakian BJ

    更新日期:1995-08-01 00:00:00

  • Up-regulation of beta 1-adrenergic receptors in rat brain after chronic citalopram and fluoxetine treatments.

    abstract::Quantitative receptor autoradiography was used to study the effects of the selective serotonin reuptake inhibitors citalopram and fluoxetine and the tricyclic antidepressant imipramine on the regulation of beta 1-adrenergic receptors in the rat brain. Rats were treated with saline, citalopram (10 mg kg-1), fluoxetine ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02245579

    authors: Pälvimäki EP,Laakso A,Kuoppamäki M,Syvälahti E,Hietala J

    更新日期:1994-08-01 00:00:00

  • Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons.

    abstract:INTRODUCTION:Genetic causes, or predisposition, are increasingly accepted to be part of the ethiopathogenesis of many neuropsychiatric diseases. While genes can be studied in any type of cells, their physiological function in human brain cells is difficult to evaluate, particularly in living subjects. METHODS:As a fir...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-013-3384-2

    authors: Dage JL,Colvin EM,Fouillet A,Langron E,Roell WC,Li J,Mathur SX,Mogg AJ,Schmitt MG,Felder CC,Merchant KM,Isaac J,Broad LM,Sher E,Ursu D

    更新日期:2014-03-01 00:00:00

  • Opioids for hedonic experience and dopamine to get ready for it.

    abstract:BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-006-0521-1

    authors: Barbano MF,Cador M

    更新日期:2007-04-01 00:00:00

  • Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli.

    abstract::The current study examined whether stimuli predictive of heroin availability were capable of inducing a relapse of drug-seeking behavior in an operant runway task. Olfactory stimuli (orange and almond food extract) served as discriminative cues about the availability (S+) or unavailability (S-) of heroin reinforcement...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050269

    authors: McFarland K,Ettenberg A

    更新日期:1997-05-01 00:00:00

  • Presynaptic regulation of extracellular dopamine levels in the medial prefrontal cortex and striatum during tyrosine depletion.

    abstract:RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-013-2977-0

    authors: Brodnik Z,Double M,Jaskiw GE

    更新日期:2013-05-01 00:00:00

  • Animal models of Parkinson's disease and L-dopa induced dyskinesia: how close are we to the clinic?

    abstract:BACKGROUND:Several different animal models are currently used to research the neurodegenerative movement disorder Parkinson's disease (PD). RESULTS:Models based on the genetic deficits associated with a small percentage of sufferers demonstrate the pathological accumulation of alpha-synuclein characteristic of the dis...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-007-0931-8

    authors: Lane E,Dunnett S

    更新日期:2008-08-01 00:00:00

  • Dietary additives and the acquisition of cocaine self-administration in rats.

    abstract::The effects of dietary caffeine and the amount and palatability of food on the acquisition of cocaine (0.2 mg/kg) self-administration were examined. Using an autoshaping procedure, seven groups of 13 rats each were trained to press a lever resulting in a cocaine (0.2 mg/kg infusion under a fixed-ratio 1 (FR 1) schedul...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050596

    authors: Carroll ME,Lac ST

    更新日期:1998-05-01 00:00:00

  • Alcohol-induced increases in smoking behavior for nicotinized and denicotinized cigarettes in men and women.

    abstract:INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-009-1638-9

    authors: King A,McNamara P,Conrad M,Cao D

    更新日期:2009-11-01 00:00:00

  • The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

    abstract:RATIONALE:Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is little information regardi...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-005-0217-y

    authors: Hodge CW,Miles MF,Sharko AC,Stevenson RA,Hillmann JR,Lepoutre V,Besheer J,Schroeder JP

    更新日期:2006-01-01 00:00:00

  • A new method for the evaluation of benzodiazepines based on their ability to block muscimol-induced myoclonic jerks in mice.

    abstract::A number of clinically used benzodiazepines were tested for their effectiveness in blocking muscimol-induced myoclonic jerks in mice. Their ED50 values were determined from their dose-response curves. These data gave the following relative potencies with respect to diazepam: diazepam = 1, medazepam = 0.24, oxazepam = ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00432441

    authors: Menon MK,Vivonia CA,Haddox VG

    更新日期:1981-01-01 00:00:00

  • NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice.

    abstract:RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-012-2734-9

    authors: Newman EL,Chu A,Bahamón B,Takahashi A,Debold JF,Miczek KA

    更新日期:2012-11-01 00:00:00

  • Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.

    abstract:RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-014-3793-x

    authors: Viana TG,Hott SC,Resstel LB,Aguiar DC,Moreira FA

    更新日期:2015-05-01 00:00:00

  • Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients.

    abstract:RATIONALE:Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds. OBJECTIVES:To replicate previous studies in subjects with MDD who had been drug free for a...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00213-003-1475-1

    authors: Porter RJ,Gallagher P,Watson S,Smith MS,Young AH

    更新日期:2003-08-01 00:00:00

  • Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition.

    abstract:RATIONALE:Impulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement. OBJECTIVE:Employ functional magnetic resonance imaging (f...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-013-3038-4

    authors: Kareken DA,Dzemidzic M,Wetherill L,Eiler W 2nd,Oberlin BG,Harezlak J,Wang Y,O'Connor SJ

    更新日期:2013-07-01 00:00:00

  • Effects of chlordiazepoxide training dose on the mixed agonist-antagonist properties of benzodiazepine receptor antagonist Ro 15-1788, in a drug discrimination procedure.

    abstract::In experiment 1, rats (n = 12) were trained to discriminate the benzodiazepine (BDZ) compound chlordiazepoxide (CDP, 20 mg/kg, IP) from saline in a two-lever food-reinforced procedure, and subsequently were tested for stimulus control with different doses of CDP, Ro 15-1788 (a proposed BDZ receptor antagonist) and Ro ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00652236

    authors: De Vry J,Slangen JL

    更新日期:1986-01-01 00:00:00

  • Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models.

    abstract:BACKGROUND AND RATIONALE:Epidemiological evidence suggests that people who begin experimenting with drugs of abuse during early adolescence are more likely to develop substance use disorders (SUDs), but this correlation does not guarantee causation. Animal models, in which age of onset can be tightly controlled, offer ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-009-1585-5

    authors: Schramm-Sapyta NL,Walker QD,Caster JM,Levin ED,Kuhn CM

    更新日期:2009-09-01 00:00:00

  • Reinforcing effectiveness of nicotine in nonhuman primates: effects of nicotine dose and history of nicotine self-administration.

    abstract:RATIONALE:Despite the high prevalence of nicotine use in humans, robust nicotine self-administration has been difficult to demonstrate in laboratory animals. OBJECTIVES:A parametric analysis of nicotine self-administration was conducted to study its reinforcing effects in nonhuman primates. METHODS:Adult rhesus macaq...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-016-4293-y

    authors: Kohut SJ,Bergman J

    更新日期:2016-07-01 00:00:00

  • Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers.

    abstract:RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05463-6

    authors: Jensen KP,Valentine G,Gueorguieva R,Sofuoglu M

    更新日期:2020-05-01 00:00:00

  • Adrenalectomy reverses chronic injection-induced tolerance to nicotine.

    abstract::A recent study from our laboratory has demonstrated that C57BL/6 male mice that are chronically injected with nicotine develop a profound tolerance to nicotine that is not associated with changes in brain nicotinic receptors. We have proposed that alterations in the secretion of corticosterone (CCS) may regulate toler...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02245877

    authors: Grun EA,Pauly JR,Collins AC

    更新日期:1992-01-01 00:00:00