Abstract：
:A neutral stimulus can acquire conditioned rewarding properties through association with an intrinsically rewarding stimulus. The acquisition of responding for conditioned rewards requires that environmental stimuli and reward processes interact in a highly specific manner; analyses of this phenomenon may provide valuable insight into the processes that underlie reward-related learning. The effects of dopaminergic agents with different mechanisms of action in this paradigm have revealed several interesting dissociations suggesting that a rewarding signal at dopamine D1-like receptors may mediate both the acquisition of rewarding properties by neutral stimuli and their ability to control behavior. Dopamine-induced changes in responding for conditioned reward are susceptible to modulation by other neurotransmitter systems. In many cases, the molecular and cellular bases of these interactions support the notion that signaling through D1-like receptors is critical for a conditioned reward to direct responding. The model outlined in this paper reflects a comprehensive integration of the existing literature in the field, and has several implications that are readily testable by future research. Moreover, given the known biochemical coupling of D1-like receptors, this model may help in characterizing the sequence of intracellular events, from signal transduction to possible transcriptional and/or translational regulation, that give rise to the acquisition of rewarding properties by neutral stimuli.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Sutton MA,Beninger RJdoi
10.1007/s002130050982subject
Has Abstractpub_date
1999-05-01 00:00:00pages
95-110issue
2eissn
0033-3158issn
1432-2072journal_volume
144pub_type
杂志文章,评审abstract：RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...
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pub_type： 杂志文章,已发布勘误
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更新日期：1998-10-01 00:00:00
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更新日期：1982-01-01 00:00:00
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更新日期：2001-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00423257
更新日期：1976-07-28 00:00:00
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pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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更新日期：1997-09-01 00:00:00
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更新日期：1999-01-01 00:00:00
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更新日期：2011-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1976-08-17 00:00:00
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更新日期：1995-08-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：1996-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2008-03-01 00:00:00
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