Abstract：
BACKGROUND:Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. METHODS:A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This was repeated following up to 8 weeks of anti-psychotic treatment. Ten patients had repeat scan within only 3 weeks. The choice of anti-psychotic medication was naturalistic, i.e., clinician-led. Well-matched healthy individuals were also scanned to control for non-specific changes over a 3-week period. RESULTS:After 3 weeks of anti-psychotic treatment, significant grey matter volume increase in the right caudate, superior and inferior frontal gyrus, precentral gyrus, and left inferior parietal lobule was noted. However, after 8 weeks of anti-psychotic treatment, volume increase in the right thalamus and bilateral cerebellum was observed. Significant grey matter reduction was detected in the left medial frontal gyrus at both 3- and 8-week intervals. CONCLUSIONS:Early increase in striatal volume change occurs as early as 3 weeks after anti-psychotic treatment, whilst thalamic volume increase is apparent later, by 8 weeks of treatment. We speculate that drug-mediated neuroplasticity may provide a biomarker for clinical recovery.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Deng MY,McAlonan GM,Cheung C,Chiu CP,Law CW,Cheung V,Sham PC,Chen EY,Chua SEdoi
10.1007/s00213-009-1619-zsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
437-46issue
3eissn
0033-3158issn
1432-2072journal_volume
206pub_type
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