Abstract:
RATIONALE:It has been suggested that GABA(B) receptors may be part of a neural substrate mediating some of the effects of ethanol. OBJECTIVE:The purpose of this experiment was to investigate, in mice, the effects of ethanol on working memory in a delayed matching-to position (DMTP) task, and additionally to determine if these effects were modulated by GABA(B) receptors. METHODS:Female C57BL/6J and DBA/2J mice were trained in the DMTP task, and after asymptotic levels of performance accuracy were achieved, injections (IP) of ethanol, baclofen, or phaclofen were administered. Baclofen or phaclofen were then co-administered with ethanol. Each test was repeated twice. RESULTS:Ethanol caused deficits in working memory at 2.0 g/kg and higher. The highest dose (2.5 g/kg) produced additional non-specific effects, indicative of sedation. Baclofen increased performance accuracy (2.5 mg/kg), while decreasing the total number of trials completed. When combined with ethanol (1.5 g/kg), baclofen increased memory deficits at the highest dose (7.5 mg/kg). Phaclofen increased performance accuracy at 10 and 30 mg/kg but had no effect on the total number of trials completed. When combined with ethanol (2.5 g/kg), phaclofen did not significantly alter ethanol-induced deficits in performance. CONCLUSIONS:Analyses of performance accuracy, total trials completed and variables indexing bias and motor impairment indicated that GABA(B) drugs modulate working memory in a behaviorally specific manner. Overall, these receptors may be part of a neural substrate that modulates some of the effects of ethanol.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Escher T,Mittleman Gdoi
10.1007/s00213-004-1875-xsubject
Has Abstractpub_date
2004-11-01 00:00:00pages
166-74issue
2eissn
0033-3158issn
1432-2072journal_volume
176pub_type
杂志文章abstract:RATIONALE:A number of studies have indicated a relationship between the intake of palatable foods or fluids and drug self-administration. OBJECTIVES:Two experiments were conducted to determine whether the intake of sucrose or fat was related to subsequent cocaine self-administration. METHODS:In separate groups of rat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000375
更新日期:2000-04-01 00:00:00
abstract:RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100700
更新日期:2001-05-01 00:00:00
abstract:RATIONALE:Withdrawal seizure-prone and withdrawal seizure-resistant mice were selectively bred to exhibit differences in handling-induced convulsion severity during ethanol withdrawal. The glutamatergic system has been implicated in seizure activity as well as ethanol withdrawal symptoms. OBJECTIVE:This study assessed...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050933
更新日期:1999-04-01 00:00:00
abstract:RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fe...
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pub_type: 杂志文章
doi:10.1007/s00213-020-05750-2
更新日期:2021-01-06 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2014-07-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/s00213-018-5149-4
更新日期:2019-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181961
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427899
更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445571
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-09-01 00:00:00
abstract:RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3801-1
更新日期:2015-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051020
更新日期:1999-06-01 00:00:00
abstract:RATIONALE:Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders. OBJECTIVES:This brief review exemplifies this appro...
journal_title:Psychopharmacology
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更新日期:2019-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432038
更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00213-009-1591-7
更新日期:2009-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244202
更新日期:1991-01-01 00:00:00
abstract::The effect of ovarian steroids on the benzodiazepine receptor was assessed in the elevated plus-maze and, after restraint stress, in benzodiazepine receptor binding assays. Vehicle-treated proestrous rats displayed anxiolytic behavior, relative to diestrus or estrous rats. Anxiolytic behavior was observed after 1 or 2...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247394
更新日期:1996-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00492369
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journal_title:Psychopharmacology
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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更新日期:2018-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-010-1835-6
更新日期:2010-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244999
更新日期:1994-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051048
更新日期:1999-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428404
更新日期:1985-01-01 00:00:00