Attenuation by pimozide of the suppressant effect of d-amphetamine on operant behaviour.

abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...

journal_title：Psychopharmacology

authors： Bowers MB Jr,Gold BI,Roth RH

更新日期：1980-01-01 00:00:00

abstract：:The relationship between each of two pharmacologic effects (tachycardia and psychological "high") of delta-9-tetrahydrocannabinol (THC) and plasma THC concentration was investigated in three male and three female experienced marihuana smokers. Each subject smoked 1% THC cigarette on two occasions separated by 2 h. Hea...

journal_title：Psychopharmacology

authors： Cocchetto DM,Owens SM,Perez-Reyes M,DiGuiseppi S,Miller LL

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Epidemiological evidence suggests that people who begin experimenting with drugs of abuse during early adolescence are more likely to develop substance use disorders (SUDs), but this correlation does not guarantee causation. Animal models, in which age of onset can be tightly controlled, offer ...

journal_title：Psychopharmacology

authors： Schramm-Sapyta NL,Walker QD,Caster JM,Levin ED,Kuhn CM

更新日期：2009-09-01 00:00:00

abstract：:Nicotine (6 mg/kg/day) was administered subcutaneously via Alzet osmotic pumps to rats for 28 days. Nociception was measured by the hot-plate and tail-flick methods. A significant antinociceptive effect was demonstrated during the first week of the treatment; after that tolerance developed, lasting for the remaining p...

journal_title：Psychopharmacology

authors： Yang CY,Wu WH,Zbuzek VK

更新日期：1992-01-01 00:00:00

abstract：:The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...

journal_title：Psychopharmacology

authors： Austermann M,Grotemeyer KH,Evers S,Rödding D,Husstedt IW

更新日期：1998-08-01 00:00:00

abstract：:Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether sc...

journal_title：Psychopharmacology

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-09-01 00:00:00

abstract：RATIONALE:Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist. OBJECTIVES:The purpose of this work was to assess V1a receptor affinity and selectivity of JNJ-17308616 and in vivo efficacy in ...

journal_title：Psychopharmacology

authors： Bleickardt CJ,Mullins DE,Macsweeney CP,Werner BJ,Pond AJ,Guzzi MF,Martin FD,Varty GB,Hodgson RA

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Nicotinic acetylcholine systems play major roles in cognitive function. Nicotine and a variety of nicotinic agonists improve attention, and nicotinic antagonist exposure impairs it. This study was conducted to investigate the effect of a novel nicotinic receptor agonist at α4β2 nicotinic recept...

journal_title：Psychopharmacology

authors： Rezvani AH,Cauley MC,Johnson EC,Gatto GJ,Levin ED

更新日期：2012-10-01 00:00:00

abstract：:The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...

journal_title：Psychopharmacology

authors： Turski L,Turski W,Czuczwar SJ,Kleinrok Z

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...

journal_title：Psychopharmacology

authors： Roche DJO,Worley MJ,Courtney KE,Bujarski S,London ED,Shoptaw S,Ray LA

更新日期：2017-07-01 00:00:00

abstract：:Rats were trained to bar-press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of morphine self-administration were enhanced by lesions of the frontal cortex and hippocampus and transiently reduced by lesions of the medial forebrain bundle and medial thalamus. Dose-response studies ...

journal_title：Psychopharmacology

authors： Glick SD,Cox RD

更新日期：1978-05-31 00:00:00

abstract：:The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...

journal_title：Psychopharmacology

authors： Iwamoto ET

更新日期：1986-01-01 00:00:00

abstract：:Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...

journal_title：Psychopharmacology

authors： Marco LA,Joshi RS,Brown C,Aldes LD,Chronister RB

更新日期：1988-01-01 00:00:00

abstract：:Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT1A agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhib...

journal_title：Psychopharmacology

authors： Prinssen EP,Kleven MS,Koek W

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:The majority of pharmacotherapies proposed for cocaine dependence have been marginally effective and frequently have undesirable side effects. We recently demonstrated that short-term treatment with citicoline decreased self-reported desire to use cocaine in crack cocaine users. OBJECTIVE:The present study w...

journal_title：Psychopharmacology

authors： Lukas SE,Kouri EM,Rhee C,Madrid A,Renshaw PF

更新日期：2001-09-01 00:00:00

abstract：:The modulation of spontaneous (social and individual) behaviour as a function of the age of the rat (1, 3, 6, 12, 18 and 24 months) and of scopolamine dose (0.1, 0.2, 0.3 and 0.5 mg/kg) was studied. Observations were conducted during the dark phase of the reverse light/dark schedule using a reintroduction procedure. R...

journal_title：Psychopharmacology

authors： Soffié M,Bronchart M

更新日期：1988-01-01 00:00:00

abstract：:Ethologic analysis has been used to study the behavioural effects following injection of delta-aminolaevulinic acid (ALA) in mice. After a dose level of 1.6 mmol ALA/kg, male and female mice showed periods of immobility and scanned less frequently than saline-injected controls. Exploration of the cage was significantl...

journal_title：Psychopharmacology

authors： Cutler MG,Moore MR,Ewart FG

更新日期：1979-03-22 00:00:00

abstract：:Two studies were conducted to replicate and extend previous demonstrations of smoking-induced, dose-related reports of euphoria, and to confirm this relationship using measures of plasma nicotine. In experiment 1, overnight-deprived subjects, in three different sessions, smoked ultralow-, high-nicotine, and usual-bran...

journal_title：Psychopharmacology

authors： Pomerleau CS,Pomerleau OF

更新日期：1992-01-01 00:00:00

abstract：:A neutral stimulus can acquire conditioned rewarding properties through association with an intrinsically rewarding stimulus. The acquisition of responding for conditioned rewards requires that environmental stimuli and reward processes interact in a highly specific manner; analyses of this phenomenon may provide valu...

journal_title：Psychopharmacology

authors： Sutton MA,Beninger RJ

更新日期：1999-05-01 00:00:00

abstract：RATIONALE:An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia. OBJECTIVES:The objective of this study is to determine the effect of intrav...

journal_title：Psychopharmacology

authors： Nottage JF,Stone J,Murray RM,Sumich A,Bramon-Bosch E,Ffytche D,Morrison PD

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:Endogenous γ-aminobutyric acidA receptor (GABAAR)-active neurosteroids (e.g., allopregnanolone) regulate central nervous system excitability and many physiological functions, so fluctuations are implicated in several neuropsychiatric disorders. Pertinently, evidence supports an inverse relationship between en...

journal_title：Psychopharmacology

authors： Jensen JP,Nipper MA,Helms ML,Ford MM,Crabbe JC,Rossi DJ,Finn DA

更新日期：2017-09-01 00:00:00

abstract：:Intracerebroventricular injections of gamma-aminobutyric acid (GABA) and of the GABA-transaminase inhibitor, ethanolamine-O-sulphate (EOS), decreased the food intake of freely-fed (GABA and EOS) and food-deprived rats (EOS). The effect, still evident 24 h after treatment, was not decreased by the GABA receptor-blocker...

journal_title：Psychopharmacology

authors： Olgiati VR,Netti C,Guidobono F,Pecile A

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of th...

journal_title：Psychopharmacology

authors： Orsetti M,Ferretti C,Gamalero R,Ghi P

更新日期：2002-01-01 00:00:00

abstract：:The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...

journal_title：Psychopharmacology

authors： Rebec GV,White IM,Puotz JK

更新日期：1997-04-01 00:00:00

abstract：:The cataleptogenic effect of delta 9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 of delta 9-THC for catalepsy in experimentally naive rats was not diff...

journal_title：Psychopharmacology

authors： Prescott WR,Gold LH,Martin BR

更新日期：1992-01-01 00:00:00

abstract：:In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These th...

journal_title：Psychopharmacology

authors： Francès H,Lecrubier Y,Puech AJ,Simon P

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...

journal_title：Psychopharmacology

authors： Tidey JW,Rohsenow DJ,Kaplan GB,Swift RM,Reid N

更新日期：2011-09-01 00:00:00

abstract：:BIMT 17, the only compound reported to be a full 5-HT1A agonist and a 5-HT2A antagonist at the frontal cortex, was assessed in three animal paradigms sensitive to antidepressants in rats: olfactory bulbectomy (OB), differential-reinforcement-of-low rate 72-s (DRL 72-s) and learned helplessness (LH). In the OB rats, BI...

journal_title：Psychopharmacology

authors： Borsini F,Cesana R,Kelly J,Leonard BE,McNamara M,Richards J,Seiden L

更新日期：1997-12-01 00:00:00

abstract：:Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice. Repeated administration (5 times at 3 to 4-day intervals) of MAP, but not CAF, induced sensitization to its effect. Furthermore, the mice repeatedly receiving CAF showed no significant ch...

journal_title：Psychopharmacology

authors： Kuribara H

更新日期：1994-10-01 00:00:00

abstract：:It was the aim of the present study to determine the affinities of four neuroleptics and five antidepressants for histamine H3 receptors. In rat brain cortex membranes, the specifically bound [3H]-N alpha-methylhistamine was monophasically displaced by clozapine (pKi 6.15). The other drugs did not completely displace ...

journal_title：Psychopharmacology

authors： Kathmann M,Schlicker E,Göthert M

更新日期：1994-12-01 00:00:00