Clozapine's functional mesolimbic selectivity is not duplicated by the addition of anticholinergic action to haloperidol: a brain stimulation study in the rat.

abstract：RATIONALE:Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear. OBJECTIVES:To determine the effects of chronic buprenorphine treatment on intake of heroin and/or cocaine and measure nucleus accumbens (NAc) dopamine (DA) levels during self-administration. METHODS:In...

journal_title：Psychopharmacology

authors： Sorge RE,Stewart J

更新日期：2006-09-01 00:00:00

abstract：:The effect of two subcutaneous injections of 0.6 mg nicotine, administered 40 min apart, was compared with placebo in four non-smoking subjects in a counter-balanced double-blind crossover design. The nicotine injections produced mean peak plasma nicotine concentrations of 5.3 ng/ml 10 min after the first injection an...

journal_title：Psychopharmacology

authors： Foulds J,McSorley K,Sneddon J,Feyerabend C,Jarvis MJ,Russell MA

更新日期：1994-06-01 00:00:00

abstract：RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...

journal_title：Psychopharmacology

authors： Fisk JE,Montgomery C,Wareing M,Murphy PN

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Several theories propose alternative explanations for drug addiction. OBJECTIVES:We propose a general theory of transition to addiction that synthesizes knowledge generated in the field of addiction into a unitary explanatory frame. MAJOR PRINCIPLES OF THE THEORY:Transition to addiction results from a sequ...

journal_title：Psychopharmacology

authors： Piazza PV,Deroche-Gamonet V

更新日期：2013-10-01 00:00:00

abstract：RATIONAL:Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES:We investigated the role of leptin and ghrelin in the augmentation of heroin seekin...

journal_title：Psychopharmacology

authors： D'Cunha TM,Chisholm A,Hryhorczuk C,Fulton S,Shalev U

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:The purpose of the present investigation was to evaluate the effects of the D3 agonist (+/-)-7-hydroxy-dipropylaminotetralin (7-OH-DPAT), various dopamine (DA) agonists and DA antagonists on the antinociceptive effects of mu opioids. METHODS:Antinociception was assessed using a warm-water tail-withdrawal pro...

journal_title：Psychopharmacology

authors： Cook CD,Rodefer JS,Picker MJ

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...

journal_title：Psychopharmacology

authors： Albelda N,Bar-On N,Joel D

更新日期：2010-05-01 00:00:00

abstract：RATIONALE:Schizophrenia is characterized by a large variety of cognitive symptoms, among which information processing deficits have been extensively studied. So far, these aspects have been found to be remarkably stable and effective treatment is still lacking. Traditionally, information processing is subdivided into p...

journal_title：Psychopharmacology

authors： Ellenbroek BA

更新日期：2004-06-01 00:00:00

abstract：:The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated while living on a research unit. Eleven were maintained on methadone...

journal_title：Psychopharmacology

authors： Preston KL,Sullivan JT,Strain EC,Bigelow GE

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia. OBJECTIVES:The objective of this study is to determine the effect of intrav...

journal_title：Psychopharmacology

authors： Nottage JF,Stone J,Murray RM,Sumich A,Bramon-Bosch E,Ffytche D,Morrison PD

更新日期：2015-02-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Previous studies show that electrical stimulation of the ventral subiculum (vSub) can reinstate drug-seeking behavior in rats following extinction. This study examined whether vSub stimulation could also evoke reinitiation of d-amphetamine (d-AMPH) self-administration during voluntary abstinenc...

journal_title：Psychopharmacology

authors： Taepavarapruk P,Phillips AG

更新日期：2003-07-01 00:00:00

abstract：:The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice render...

journal_title：Psychopharmacology

authors： Ulkü E,Ayhan IH,Tulunay FC,Uran B,Kaymakçalan S

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:New research findings in the field of neuroactive steroids strongly suggest that to understand their role in physiopathology, it is essential to accurately measure their tissue levels. Through his broad chemical expertise and extensive knowledge of steroids, Dr. Robert H. Purdy pioneered structure-activity re...

journal_title：Psychopharmacology

authors： Vallée M

更新日期：2014-09-01 00:00:00

abstract：:In an attempt to define the nature of the involvement of delta 9-tetrahydrocannabinol (THC) with central cholinergic neurotransmission, the effects of THC on direct cholinergic stimulation of the rat brain were investigated. THC, in doses of 3 mg/kg and 6 mg/kg, administered intraperitoneally (i.p.), potentiated the e...

journal_title：Psychopharmacology

authors： Duncan GE,Dagirmanjian R

更新日期：1979-02-28 00:00:00

abstract：RATIONALE:Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. OBJECTIVES:The objective of this study was to evaluate the dose-effect relationship o...

journal_title：Psychopharmacology

authors： Amato JN,Marie S,Lelong-Boulouard V,Paillet-Loilier M,Berthelon C,Coquerel A,Denise P,Bocca ML

更新日期：2013-07-01 00:00:00

abstract：:In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus ...

journal_title：Psychopharmacology

authors： Kelley AE,Delfs JM

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:So-called atypical antipsychotics (AAPs) are associated with varying levels of weight gain and associated metabolic disturbances, which in patients with serious mental illness (SMI) have been linked to non-compliance and poor functional outcomes. Mechanisms underlying AAP-induced metabolic abnormalities are o...

journal_title：Psychopharmacology

authors： Benarroch L,Kowalchuk C,Wilson V,Teo C,Guenette M,Chintoh A,Nesarajah Y,Taylor V,Selby P,Fletcher P,Remington GJ,Hahn MK

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...

journal_title：Psychopharmacology

authors： Harun N,Johari IS,Mansor SM,Shoaib M

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area. OBJECTIVES:How valid, reliable, productive, and informative are the most frequently used animal models of excessive aggressive behavior? METHODS:The rationale, key methodological featur...

journal_title：Psychopharmacology

authors： Miczek KA,de Boer SF,Haller J

更新日期：2013-04-01 00:00:00

abstract：:The behavioral effects of intraventricularly (IVT) administered (-)-nicotine on food-maintained behavior were studied. Rats responded by pressing a lever under various fixed ratio (FR) schedules. Infusion of 5 microgram of (-)-nicotine suppressed responding under an FR 16 schedule for 11-13 min. The effect was inverse...

journal_title：Psychopharmacology

authors： DeNoble VJ,Dragan VP,Carron L

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...

journal_title：Psychopharmacology

authors： Hart CL,Jatlow P,Sevarino KA,McCance-Katz EF

更新日期：2000-04-01 00:00:00

abstract：:Quantitative receptor autoradiography was used to study the effects of the selective serotonin reuptake inhibitors citalopram and fluoxetine and the tricyclic antidepressant imipramine on the regulation of beta 1-adrenergic receptors in the rat brain. Rats were treated with saline, citalopram (10 mg kg-1), fluoxetine ...

journal_title：Psychopharmacology

authors： Pälvimäki EP,Laakso A,Kuoppamäki M,Syvälahti E,Hietala J

更新日期：1994-08-01 00:00:00

abstract：:The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...

journal_title：Psychopharmacology

authors： Antkiewicz-Michaluk L,Michaluk J,Romańska I,Vetulani J

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Glucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning. OBJECTIVES:The ai...

journal_title：Psychopharmacology

authors： Römer S,Schulz A,Richter S,Lass-Hennemann J,Schächinger H

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...

journal_title：Psychopharmacology

authors： Lai SW,Lin CL,Liao KF

更新日期：2015-06-01 00:00:00

abstract：:The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...

journal_title：Psychopharmacology

authors： Andrée B,Thorberg SO,Halldin C,Farde L

更新日期：1999-06-01 00:00:00

abstract：:Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...

journal_title：Psychopharmacology

authors： Hyde TM,Egan MF,Wing LL,Wyatt RJ,Weinberger DR,Kleinman JE

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Caffeine is present in many widely consumed drinks and some foods. In the fairly extensive literature on the psychostimulant effects of caffeine, there are few dose-response studies and even fewer studies of the effects of doses of caffeine lower than 50 mg (the range of the amounts of caffeine contained in, ...

journal_title：Psychopharmacology

authors： Smit HJ,Rogers PJ

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Antidepressants (ADs) are slow to produce their therapeutic effect. This long latency promotes the development of new strategies to short their onset of action. Previous reports indicated that 17beta-estradiol (E(2)) promotes the antidepressant-like activity of fluoxetine (FLX) and desipramine (DMI) in the fo...

journal_title：Psychopharmacology

authors： Estrada-Camarena E,Rivera NM,Berlanga C,Fernández-Guasti A

更新日期：2008-12-01 00:00:00

abstract：:Chlordiazepoxide (CDP) and amphetamine (AMPH) were tested, alone or in combination, in BALB/c mice pretreated with alpha-methyl-p-tyrosine (AMT) and subjected to shuttle-box avoidance training. CDP and AMPH, given alone, partly reversed avoidance depression induced by 50 mg/kg of AMT, but were ineffective in mice pret...

journal_title：Psychopharmacology

authors： Sansone M,Renzi P

更新日期：1981-01-01 00:00:00