Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes.

abstract：:Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...

journal_title：Psychopharmacology

authors： Ellinwood EH Jr,Linnoila M,Easler ME,Molter DW

更新日期：1983-01-01 00:00:00

abstract：:The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml i.v.) or received yok...

journal_title：Psychopharmacology

authors： Fuchs RA,Tran-Nguyen LT,Specio SE,Groff RS,Neisewander JL

更新日期：1998-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular...

journal_title：Psychopharmacology

authors： Kuehl LK,Muhtz C,Hinkelmann K,Dettenborn L,Wingenfeld K,Spitzer C,Otte C

更新日期：2016-09-01 00:00:00

abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...

journal_title：Psychopharmacology

authors： Wright A,Terry P

更新日期：2002-03-01 00:00:00

abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...

journal_title：Psychopharmacology

authors： Agmo A,Paredes RG,Sierra L,Garcés I

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the disc...

journal_title：Psychopharmacology

authors： Marona-Lewicka D,Chemel BR,Nichols DE

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Robust intravenous (i.v.) nicotine self-administration (SA) in rats has been reported by several laboratories, including our own, using fixed ratio (FR) schedules of reinforcement. Studies on other drugs of abuse, however, suggest that progressive ratio (PR) schedules may provide additional information not ga...

journal_title：Psychopharmacology

authors： Donny EC,Caggiula AR,Mielke MM,Booth S,Gharib MA,Hoffman A,Maldovan V,Shupenko C,McCallum SE

更新日期：1999-11-01 00:00:00

abstract：RATIONALE:Evidence suggesting that the endogenous cannabinoid (eCB) system can be manipulated to facilitate or impair extinction of learned behaviours has important consequences for opiate withdrawal and abstinence. We demonstrated that the fatty acid amide hydrolase (FAAH) inhibitor URB597, which increases eCB levels,...

journal_title：Psychopharmacology

authors： Manwell LA,Mallet PE

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:State-dependent changes in physiological arousal may influence impulsive behaviours. OBJECTIVES:To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α2-adrenergic receptor antagonist, which increases physiological arousal via noradrenaline release) on performa...

journal_title：Psychopharmacology

authors： Herman AM,Critchley HD,Duka T

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:Schedule-induced polydipsia (SIP) is an established model for studying compulsive behaviour in rats. Serotoninergic drugs effectively reduce compulsive drinking on SIP, and high compulsive drinker rats selected by SIP have shown differences in serotoninergic brain activity. However, the specific serotoninergi...

journal_title：Psychopharmacology

authors： Navarro SV,Gutiérrez-Ferre V,Flores P,Moreno M

更新日期：2015-02-01 00:00:00

abstract：:These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0-8.0 mg/kg pilocarpine increased chewing movements and tongue pro...

journal_title：Psychopharmacology

authors： Salamone JD,Johnson CJ,McCullough LD,Steinpreis RE

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...

journal_title：Psychopharmacology

authors： Voorhees CM,Cunningham CL

更新日期：2011-04-01 00:00:00

abstract：RATIONALE:Drug-associated environmental stimuli may serve as conditioned reinforcers to enhance drug self-administration behaviors in humans and laboratory animals. However, it can be difficult to distinguish experimentally the conditioned reinforcing effects of a stimulus from other behavioral processes that can chang...

journal_title：Psychopharmacology

authors： Bertz JW,Woods JH

更新日期：2013-09-01 00:00:00

abstract：RATIONALE:The Scheduled High Alcohol Consumption (SHAC) binge drinking model is a simple, partial murine model with which to investigate some of the neurobiological underpinnings of alcoholism. OBJECTIVES:The SHAC model was used to characterize monoamine and amino acid adaptations produced in the nucleus accumbens (NA...

journal_title：Psychopharmacology

authors： Szumlinski KK,Diab ME,Friedman R,Henze LM,Lominac KD,Bowers MS

更新日期：2007-03-01 00:00:00

abstract：:The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...

journal_title：Psychopharmacology

authors： Nurnberger JI Jr,Simmons-Alling S,Kessler L,Jimerson S,Schreiber J,Hollander E,Tamminga CA,Nadi NS,Goldstein DS,Gershon ES

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) cont...

journal_title：Psychopharmacology

authors： Isola R,Zhang H,Tejwani GA,Neff NH,Hadjiconstantinou M

更新日期：2009-01-01 00:00:00

abstract：RATIONALE:The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of b...

journal_title：Psychopharmacology

authors： Xu H,Das S,Sturgill M,Hodgkinson C,Yuan Q,Goldman D,Grasing K

更新日期：2017-08-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) antagonists induce psychotomimetic effects in humans that closely resemble negative and cognitive symptoms of schizophrenia. NMDA agonists, in contrast, may significantly ameliorate such symptoms. In rodents, phencyclidine (PCP) and other NMDA antagonists induce a hyperlocomotory syndrome t...

journal_title：Psychopharmacology

authors： Javitt DC,Frusciante M

更新日期：1997-01-01 00:00:00

abstract：:Ethanol-induced locomotor stimulation has been proposed to be positively correlated with the rewarding effects of ethanol (Wise and Bozarth 1987). The present experiments provided a test of this hypothesis using a genetic model. Three behavioral indices of the motivational effects of ethanol (drinking, taste condition...

journal_title：Psychopharmacology

authors： Risinger FO,Malott DH,Prather LK,Niehus DR,Cunningham CL

更新日期：1994-10-01 00:00:00

abstract：:Preclinical studies have exploded our knowledge about the behavioral and biological underpinnings of alcoholism. These studies suggest that certain neurotransmitters, particularly those interacting with the opioid, N-methyl-D-aspartate, and monoamine systems, may play a critical role in the expression of alcohol-drink...

journal_title：Psychopharmacology

authors： Johnson BA,Ait-Daoud N

更新日期：2000-05-01 00:00:00

abstract：:The antagonist effects of clocinnamox were evaluated against opioid agonists, acting at mu, kappa and delta-receptors, in rhesus monkeys (n = 3-4) responding under a fixed-ratio 30 (FR 30) schedule for food delivery. Clocinnamox (0.032-0.1 mg/kg) dose-dependently antagonized fentanyl (0.001-0.32 mg/kg) after either a ...

journal_title：Psychopharmacology

authors： Butelman ER,Negus SS,Lewis JW,Woods JH

更新日期：1996-02-01 00:00:00

abstract：:Two behaviors related to nonreward (omission of water in an enclosure where the rats were habituated to drink) were studied. The time spent licking the bottles during water omission and the time spent drinking during a subsequent 5-min drinking session (water available) were recorded. The drinking session was performe...

journal_title：Psychopharmacology

authors： Soubrié P,Thiébot MH,Simon P,Boissier JR

更新日期：1978-09-15 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a paradigm of sensory gating with potential predictive and construct validity towards schizophrenia. OBJECTIVES:Establishment of a mouse PPI paradigm in which typical and atypical antipsychotic drugs directly improve a low perf...

journal_title：Psychopharmacology

authors： Olivier B,Leahy C,Mullen T,Paylor R,Groppi VE,Sarnyai Z,Brunner D

更新日期：2001-07-01 00:00:00

abstract：:The asymptomatic and clinical stages of Parkinson's disease (PD) are associated with comorbid non-motor symptoms including gastrointestinal (GI) dysfunction. Although the neuroprotective and gastroprotective roles of kolaviron (KV) have been reported independently, whether KV-mediated GI-protective capacity could be b...

journal_title：Psychopharmacology

authors： Farombi EO,Awogbindin IO,Olorunkalu PD,Ogbuewu E,Oyetunde BF,Agedah AE,Adeniyi PA

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...

journal_title：Psychopharmacology

authors： Forlenza OV,Wacker P,Nunes PV,Yacubian J,Castro CC,Otaduy MC,Gattaz WF

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:A variety of behavioral procedures have been developed to assess cannabinoid activity in mice; however, the feasibility of establishing Delta(9)-THC as a discriminative stimulus in mice has not been documented. OBJECTIVE:One goal was to establish Delta(9)-THC as a discriminative stimulus in mice; after havin...

journal_title：Psychopharmacology

authors： McMahon LR,Ginsburg BC,Lamb RJ

更新日期：2008-07-01 00:00:00

abstract：:Oral administration of the serotonin (5-HT) precursor L-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man. L-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1c antagoni...

journal_title：Psychopharmacology

authors： Lee MA,Nash JF,Barnes M,Meltzer HY

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Despite the critical role attributed to phosphorylated extracellular signal regulated kinase (pERK1/2) in the nucleus accumbens (Acb) in the actions of addictive drugs, the effects of morphine on ERK1/2 phosphorylation in this area are still controversial. OBJECTIVES:In order to investigate further this issu...

journal_title：Psychopharmacology

authors： Rosas M,Porru S,Fenu S,Ruiu S,Peana AT,Papale A,Brambilla R,Di Chiara G,Acquas E

更新日期：2016-08-01 00:00:00

abstract：:The alcohol-preferring AA rats have previously been shown to drink more solution containing the opioid etonitazene than the alcohol-avoiding ANA rats. The present experiments were initiated to see whether the line difference in opioid and alcohol intake would persist if an intravenous (i.v.) route of self-administrati...

journal_title：Psychopharmacology

authors： Hyytiä P,Schulteis G,Koob GF

更新日期：1996-06-01 00:00:00

abstract：RATIONALE:Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely. OBJECTIVE:Compounds with selectivity for GABAA receptor subtypes were used to evaluate the role of GABAA receptors containing alpha1 an...

journal_title：Psychopharmacology

authors： Duke AN,Platt DM,Cook JM,Huang S,Yin W,Mattingly BA,Rowlett JK

更新日期：2006-08-01 00:00:00