Reinforcing effects of methylphenidate: influence of dose and behavioral demands following drug administration.

abstract：:The increasing interest in subjective well-being and quality of life of schizophrenic patients represents a conceptual shift in therapeutic outcome criteria. Symptom reduction alone was the most essential outcome parameter for a long time; with the development of atypical antipsychotics more ambitious success criteria...

journal_title：Psychopharmacology

authors： Karow A,Naber D

更新日期：2002-06-01 00:00:00

abstract：RATIONALE:There is a close relationship between arousal and pupil diameter, decrease in the level of arousal being accompanied by constriction of the pupil (miosis), probably reflecting the attenuation of sympathetic outflow as sedation sets in. Paradoxically, sedation induced by benzodiazepines is not accompanied by m...

journal_title：Psychopharmacology

authors： Hou RH,Samuels ER,Langley RW,Szabadi E,Bradshaw CM

更新日期：2007-11-01 00:00:00

abstract：RATIONALE:The search for novel antipsychotic drugs to treat schizophrenia is driven by the poor treatment efficacy, serious side effects, and poor patient compliance of current medications. Recently, a class of compounds known as tetrahydroprotoberberines, which includes the compound d,l-govadine, have shown promise in...

journal_title：Psychopharmacology

authors： Lins BR,Marks WN,Phillips AG,Howland JG

更新日期：2017-04-01 00:00:00

abstract：:Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...

journal_title：Psychopharmacology

authors： Myers RD,Swartzwelder HS,Dyer RS

更新日期：1982-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Estradiol decline has been associated with depression and anxiety in post-menopausal women. Agomelatine (Ago) is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT2c receptors. The present study aimed to evaluate the effects of combining Ago with 17β-estr...

journal_title：Psychopharmacology

authors： El-Khatib YA,Sayed RH,Sallam NA,Zaki HF,Khattab MM

更新日期：2020-09-01 00:00:00

abstract：:The behavioral responses to separate and combined administration of the D1 agonist SKF-38393 and the D2 agonist quinpirole following acute dopamine (DA) depletion via alpha-methyl-p-tyrosine (AMPT) or AMPT/reserpine were examined in infant (10-day-old) and weanling (21-day-old) rat pups. At both ages, AMPT pretreatmen...

journal_title：Psychopharmacology

authors： Moody CA,Spear LP

更新日期：1992-01-01 00:00:00

abstract：:The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produce...

journal_title：Psychopharmacology

authors： Smith A,Piercey M,Roberts DC

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Impulsivity has been strongly linked to addictive behaviors, but can be operationalized in a number of ways that vary considerably in overlap, suggesting multidimensionality. OBJECTIVE:This study tested the hypothesis that the latent structure among multiple measures of impulsivity would reflect the followin...

journal_title：Psychopharmacology

authors： MacKillop J,Weafer J,C Gray J,Oshri A,Palmer A,de Wit H

更新日期：2016-09-01 00:00:00

abstract：RATIONALE:Prospective memory pervades our daily lives and failures can have detrimental consequences. This ability to execute delayed intentions may be impacted by stress, yet few studies have examined these effects. Moreover, as many cannabis users report using cannabis to cope with stress, it is important to understa...

journal_title：Psychopharmacology

authors： Cuttler C,Spradlin A,Nusbaum AT,Whitney P,Hinson JM,McLaughlin RJ

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...

journal_title：Psychopharmacology

authors： Broadbear JH,Winger G,Rice KC,Woods JH

更新日期：2002-11-01 00:00:00

abstract：INTRODUCTION:Gelsemine is a natural alkaloid extracted from Gelsemium elegans Benth., a traditional Chinese medicinal herb. Gelsemine has been shown to penetrate the brain, and could produce neurological activities, such as anxiolytic and neuralgia-alleviating effects, suggesting that this natural compound might be use...

journal_title：Psychopharmacology

authors： Chen L,Pan H,Bai Y,Li H,Yang W,Lin ZX,Cui W,Xian YF

更新日期：2020-07-01 00:00:00

abstract：RATIONALE/OBJECTIVES:The impact of raising glycaemia by ingestion of a glucose drink has revealed cognitive facilitation, particularly for memory and attention. This study aimed to extend current knowledge by examining, for the first time, whether glucose load also moderates task-related (TRT) and task-unrelated though...

journal_title：Psychopharmacology

authors： Birnie LH,Smallwood J,Reay J,Riby LM

更新日期：2015-08-01 00:00:00

abstract：:Acute and chronic effects of ethosuximide (40, 80, and 120 mg/kg), phenytoin (2.5, 5, and 7.5 mg/kg), clonazepam (0.25, 0.5, and 0.75 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were examined in pigeons performing under a delayed-matching-to-sample procedure. Acute administration of clonazepam or valproic acid p...

journal_title：Psychopharmacology

authors： Poling A,Picker M,Vande Polder D,Clark R

更新日期：1986-01-01 00:00:00

abstract：:Effects of two dosages of rubidium chloride on exploration, locomotion, rearing and immobility were assessed for male and female rats in an exploration box and an open field. In contrast to previous findings, rubidium was found to decrease locomotion and rearing in the exploratory box, and also to decrease locomotion ...

journal_title：Psychopharmacology

authors： Syme GJ,Syme LA

更新日期：1979-03-22 00:00:00

abstract：:Rats may produce ultrasonic vocalizations (USV) in threatening situations. USV of adult male rats in association with aversive stimulation was evaluated as a screening method for anxiolytic drugs. The triazolobenzodiazepine alprazolam, the 5-HT uptake inhibitors fluvoxamine and clomipramine, the mixed 5-HT/NA uptake i...

journal_title：Psychopharmacology

authors： Molewijk HE,van der Poel AM,Mos J,van der Heyden JA,Olivier B

更新日期：1995-01-01 00:00:00

abstract：RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...

journal_title：Psychopharmacology

authors： Kamens HM,Phillips TJ

更新日期：2008-02-01 00:00:00

abstract：:The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during probenecid administration...

journal_title：Psychopharmacology

authors： Dunner DL,Heiber S,Perel JM

更新日期：1977-08-16 00:00:00

abstract：RATIONALE:Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions). OBJECTIVE:This study compared the influence of the presence vs absence of dose instructions on the subjective an...

journal_title：Psychopharmacology

authors： Perkins KA,Doyle T,Ciccocioppo M,Conklin C,Sayette M,Caggiula A

更新日期：2006-03-01 00:00:00

abstract：RATIONALE:The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been per...

journal_title：Psychopharmacology

authors： Serrano A,Vadas E,Ferrer B,Bilbao A,Granado N,Suárez J,Pavon FJ,Moratalla R,Rodríguez de Fonseca F

更新日期：2021-02-01 00:00:00

abstract：:Measurements of the amplitude and latency of the P3b component of the event-related potential (ERP), simple reaction time (SRT) and four psychomotor tests (VAS, DSST, DSp and CFF) were made on 12 male subjects (aged 19-24 years) 1.0-1.5 and 4.0-4.5 h after single oral doses of triprolidine (7.5 mg), terfenadine (60 mg...

journal_title：Psychopharmacology

authors： Swire FM,Marsden CA,Barber C,Birmingham AT

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Intramuscular (IM) conventional antipsychotics and/or benzodiazepines are effective in the short-term treatment of acutely agitated psychotic patients but may be associated with adverse effects. A short-acting IM formulation of the novel antipsychotic, ziprasidone, which may offer advantages over conventional...

journal_title：Psychopharmacology

authors： Daniel DG,Potkin SG,Reeves KR,Swift RH,Harrigan EP

更新日期：2001-05-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of cholinergic receptor blockade in the rat prefrontal cortex on cognitive processes. The nicotinic antagonists neuronal bungarotoxin and dihydro-beta-erythroidine and the muscarinic antagonist scopolamine were injected into the prelimbic area of the prefrontal ...

journal_title：Psychopharmacology

authors： Granon S,Poucet B,Thinus-Blanc C,Changeux JP,Vidal C

更新日期：1995-05-01 00:00:00

abstract：:MA rats, bred for greater motor impairment following subhypnotic doses of ethanol, were found to be more sensitive to the hypnotic effects of phenobarbital and chloral hydrate than were LA rats. In addition, the previously reported finding of a difference between the two lines of rats in duration of loss of righting r...

journal_title：Psychopharmacology

authors： Riley EP,Shapiro NR,Lochry EA

更新日期：1979-02-28 00:00:00

abstract：RATIONALE:Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood. OBJECTIVES:The aim of the present study was to examine the effects of the opioid antagonist, naltrexone, on neural response to rewarding and aversive sight an...

journal_title：Psychopharmacology

authors： Murray E,Brouwer S,McCutcheon R,Harmer CJ,Cowen PJ,McCabe C

更新日期：2014-11-01 00:00:00

abstract：:Prepulse inhibition (PPI) of an acoustic startle response is impaired in schizophrenics. PPI can also be studied in the rat, and is impaired by dopamine (DA) D2/3 receptor agonists such as apomorphine. This disruption is reversed by DA antagonists, leading to proposals that this approach may be a useful means to ident...

journal_title：Psychopharmacology

authors： Varty GB,Higgins GA

更新日期：1995-11-01 00:00:00

abstract：INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...

journal_title：Psychopharmacology

authors： Koethe D,Hoyer C,Leweke FM

更新日期：2009-11-01 00:00:00

abstract：RATIONALE:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies...

journal_title：Psychopharmacology

authors： Yucel K,McKinnon MC,Taylor VH,Macdonald K,Alda M,Young LT,MacQueen GM

更新日期：2007-12-01 00:00:00

abstract：RATIONALE:Several recent studies have focused on glutamate modulating agents for symptoms relief in schizophrenia, especially negative symptoms which are resistant to conventional therapies. OBJECTIVES:We aimed to assess the efficacy and tolerability of riluzole, an anti-glutamate agent with neuroprotective properties...

journal_title：Psychopharmacology

authors： Farokhnia M,Sabzabadi M,Pourmahmoud H,Khodaie-Ardakani MR,Hosseini SM,Yekehtaz H,Tabrizi M,Rezaei F,Salehi B,Akhondzadeh S

更新日期：2014-02-01 00:00:00

abstract：:EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...

journal_title：Psychopharmacology

authors： Robledo P,Lumeng L,Li TK,Ehlers CL

更新日期：1993-01-01 00:00:00

abstract：:Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...

journal_title：Psychopharmacology

authors： King DJ,Blomqvist M,Cooper SJ,Doherty MM,Mitchell MJ,Montgomery RC

更新日期：1992-01-01 00:00:00