Abstract:
RATIONALE:The social interaction test is a valuable behavioural model for testing anxiolytic drugs in rodents, quantifying the level of social behaviour between pairs of rats. OBJECTIVE:The aim of the present study was to assess the appropriateness of the social interaction test for use with a Sprague-Dawley rat line, because of increasing use of this strain in targeted mutagenesis research. METHODS:Sprague-Dawley and Wistar rats received either diazepam or mCPP or were exposed to different environmental conditions (lighting, social isolation prior testing, habituation, testing-time). General anxiety-related parameters measured were: duration of active social contact, frequency of active social contact, latency to first contact. Different forms of active social contact were recorded: number of crawls, follows and sniffs. Secondly, aversion-induced hippocampal serotonin release and serotonin content in brain regions were measured. RESULTS:In Wistar rats habituation to the test substantially increased the time of social contact, an effect comparable with treatment with diazepam (1 mg/kg), whereas changes in the lighting level had less impact. Latency to the first contact increased under "anxiety-reducing" conditions, the frequency of contacts did not change consistently. Sprague-Dawley rats behaviour did not change under varying environmental conditions, and treatment with diazepam had only sedating effects at higher doses (5 mg/kg). Anxiogenic doses of mCPP caused reduced social interaction in both strains. Serotonin release and serotonin content were higher in the anxious Wistar rats. CONCLUSIONS:Different rat strains as well as differing test conditions have a major impact on the outcome of this animal test for anxiety.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Rex A,Voigt JP,Gustedt C,Beckett S,Fink Hdoi
10.1007/s00213-004-1914-7subject
Has Abstractpub_date
2004-12-01 00:00:00pages
23-34issue
1-2eissn
0033-3158issn
1432-2072journal_volume
177pub_type
杂志文章abstract::The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174512
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1007/BF00177913
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更新日期:1997-04-01 00:00:00
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更新日期:2015-05-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-03-01 00:00:00
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更新日期:2008-11-01 00:00:00
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