Abstract:
:The effects on memory and psychomotor functions of four antidepressants which differ in sedative and anticholinergic properties were assessed. Amitriptyline (37.5, 70 mg), trazodone (100, 200 mg) viloxazine (100, 200 mg), protriptyline (10, 20 mg) or placebo were administered in a double blind, independent groups design in which 90 subjects participated. Subjects completed a battery of tests before and 2 and 4 h after drug administration. The different antidepressants produced different patterns of effects across tasks. The relatively non-sedating compounds viloxazine and protriptyline produced very similar profiles and did not impair psychomotor or memory functions. In contrast, the two more sedative antidepressants produced global impairments on test of attention, manual motor speed, recording skills and primary memory. Although both amitriptyline and trazodone impaired performance on episodic memory tasks, the effect of amitriptyline was significantly greater and this may reflect specific anticholinergic action over and above global sedative effects.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Curran HV,Sakulsriprong M,Lader Mdoi
10.1007/BF00172967subject
Has Abstractpub_date
1988-01-01 00:00:00pages
520-7issue
4eissn
0033-3158issn
1432-2072journal_volume
95pub_type
临床试验,杂志文章abstract::Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431954
更新日期:1979-04-25 00:00:00
abstract:RATIONALE:Treatment of the most widely abused drugs, nicotine and alcohol, is hampered by high rates of relapse. Varenicline tartrate, an α4β2 nicotinic receptor partial agonist, is currently prescribed as a smoking cessation aid. However, there is emerging evidence that it may also modulate alcohol seeking and cogniti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2213-8
更新日期:2011-07-01 00:00:00
abstract::The effects of amphetamine on the partial punishment effect (PPE) at one trial per day, were examined. Two groups of animals were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially punished (PP) group received food reward on every trial but in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310526
更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426811
更新日期:1979-03-14 00:00:00
abstract:RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3199-1
更新日期:2013-11-01 00:00:00
abstract::The effects of benztropine, scopolamine, atropine, methylatropine, amitriptyline, phencyclidine, and meperidine were determined alone and in conjunction with a behaviorally suppressing dose (0.05 mg/kg IM) of oxotremorine in pigeons responding under a multiple fixed-ratio 30 fixed-interval 5-min schedule of grain pres...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433492
更新日期:1981-01-01 00:00:00
abstract::This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245224
更新日期:1994-01-01 00:00:00
abstract::During the third week of life, a hyperactive period for laboratory rat, the occurrence of 8 behavioral categories was recorded in individual littermates transferred to a novel environment. Neonatal destruction of the catecholaminergic system by intraventricular injection of 6-OH-DA resulted in increased motor activity...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426882
更新日期:1978-04-28 00:00:00
abstract::Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245309
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Recent findings have shown a complexly regulated 5-HT system as it is linked to different kinds of aggression. OBJECTIVE:We focus on (1) phasic and tonic changes of 5-HT and (2) state and trait of aggression, and emphasize the different receptor subtypes, their role in specific brain regions, feed-back regul...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-010-2000-y
更新日期:2011-02-01 00:00:00
abstract::The effects of benzodiazepine (BZ) antagonists on operant behavior were examined in rats chronically administered a low dose of diazepam (DZ). The low maintenance dose of DZ (5 mg/kg twice daily) was selected as more closely associated with its anxiolytic effects than the higher treatment doses previously used to stud...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244103
更新日期:1990-01-01 00:00:00
abstract::The relationship between premenstrual dysphoria and alcohol acquistion and use patterns was studied in 14 women over 35 days on a clinical research ward. A 7-day drug-free baseline was followed by 21 days of alcohol availability and a post-alcohol drug-free period of 7 days. Women could earn alcohol or 50 cents for 30...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244221
更新日期:1990-01-01 00:00:00
abstract::Interactions of amygdala kindling and drug effects were explored in two experiments. Pretreatment with cocaine (40 mg/kg, IP) for 10 days did not significantly affect the rate of amygdala kindling compared to saline or non-kindled controls. In contrast, daily amygdala kindling with 200 microA for 0.5 s for 20 days sub...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431655
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:It has recently been shown that acute alcohol globally impairs 'prospective memory' (PM)-remembering to do something in the future (Leitz et al. in Psychopharmacology 205:379-387, 2009). In healthy, sober individuals, simulating future events at encoding enhances PM performance. AIMS:We therefore aimed to d...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1731-0
更新日期:2010-02-01 00:00:00
abstract::Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed by myo-inositol, rats were pretreated with intracerebroventricular (ICV) injections of myoinositol, artificial CSF or L-chiro-inositol. Lit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246978
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100891
更新日期:2001-12-01 00:00:00
abstract::The behavioral performance of inbred mouse strains was examined in animal models of anxiety to evaluate the potential contribution of genetic factors to fear-motivated behaviors. The preference that randomly bred mice and rats exhibit for the enclosed as opposed to the open arms of an elevated maze has been considered...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244948
更新日期:1993-01-01 00:00:00
abstract::Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4906-8
更新日期:2018-07-01 00:00:00
abstract:RATIONALE:The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. We reasoned that this system may be strongly engaged during periods of reward restriction, including food restriction. OBJECTIVES:This study examined the involvement of the orexin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2902-y
更新日期:2013-03-01 00:00:00
abstract:RATIONALE:It has been proposed that brain aldehyde dehydrogenase (ALDH) plays a role in the modulation of some psychopharmacological effects of ethanol. Diethyldithiocarbamate (DDTC), an ALDH inhibitor, elevates blood acetaldehyde levels in the presence of ethanol. Concurrent administration with 4-methylpyrazole (4-MP)...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-001-0991-0
更新日期:2002-04-01 00:00:00
abstract:RATIONALE:Research in pediatric psychopharmacology has expanded considerably in the last 10 years. Still, controversy remains about the effectiveness and safety of commonly used psychotropics and their role in child treatment, thus pointing to the need for more in-depth and targeted investigations. OBJECTIVES:To revie...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0414-3
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Negative mood states are characterized by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels. However, so far, no study examined the individual association between cortisol response and cerebral in vivo 5-HTT levels in patients su...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1903-y
更新日期:2011-02-01 00:00:00
abstract::The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245170
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1554-3
更新日期:2003-12-01 00:00:00
abstract:RATIONALE:Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions). OBJECTIVE:This study compared the influence of the presence vs absence of dose instructions on the subjective an...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0103-7
更新日期:2006-03-01 00:00:00
abstract:RATIONALE:Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: "sign-tracking" (approach toward and contact with the cue) and "goal-tracking" (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1353-y
更新日期:2009-03-01 00:00:00
abstract::Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432038
更新日期:1984-01-01 00:00:00
abstract::The 12-h brain lithium concentration was measured by lithium-7 magnetic resonance spectroscopy in ten manic-depressive patients receiving daily or alternate-day lithium carbonate treatment. The median dose of lithium carbonate was 800 mg in the daily treatment group and 1200 mg in the alternate-day group. Median 12-h ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246668
更新日期:1996-04-01 00:00:00
abstract::The authors review the literature regarding the pharmacokinetics of long-acting injectable neuroleptic drugs (LINS). There are important differences between LINS and oral neuroleptics that affect their pharmacokinetics. By avoiding first pass metabolism in gut and liver, LINS result in lower circulating concentrations...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00441937
更新日期:1989-01-01 00:00:00
abstract::The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050249
更新日期:1997-04-01 00:00:00