Comparison of alprazolam plasma levels in normal Asian and Caucasian male volunteers.

abstract：RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...

journal_title：Psychopharmacology

authors： MacKenzie G,Maguire J

更新日期：2014-09-01 00:00:00

abstract：:Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of ...

journal_title：Psychopharmacology

authors： Walsh SL,June HL,Schuh KJ,Preston KL,Bigelow GE,Stitzer ML

更新日期：1995-06-01 00:00:00

abstract：:Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that i...

journal_title：Psychopharmacology

authors： Walker MJ,Poulos CX,Le AD

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Psychostimulant sensitization heightens behavioral and motivational responses to reward-associated stimuli; however, its effects on stimuli associated with reward absence are less understood. OBJECTIVES:We examined whether amphetamine sensitization alters performance during Pavlovian-instrumental transfer (P...

journal_title：Psychopharmacology

authors： Shiflett MW,Riccie M,DiMatteo R

更新日期：2013-11-01 00:00:00

abstract：:Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...

journal_title：Psychopharmacology

authors： Biegon A,Greuner N

更新日期：1992-01-01 00:00:00

abstract：:This study was designed to compare the therapeutic and adverse effects of tranylcypromine (a monoamine oxidase inhibitor), nortriptyline (a tricyclic antidepressant), and placebo. A total of 122 depressed outpatients randomly assigned to double-blind treatment with one of these agents completed the 4-week protocol. Tr...

journal_title：Psychopharmacology

authors： White K,Razani J,Cadow B,Gelfand R,Palmer R,Simpson G,Sloane RB

更新日期：1984-01-01 00:00:00

abstract：:Pigs trained to avoid shocks by crossing a barrier in a shuttle-box according to a continuous avoidance procedure were submitted to a Pavlovian discriminative fear-conditioning procedure in which a tone was always followed by unavoidable shock (CS+) and another tone never followed by shock (CS-). The presentation of t...

journal_title：Psychopharmacology

authors： Dantzer R,Mormede P

更新日期：1976-08-26 00:00:00

abstract：RATIONALE:Several studies have demonstrated that males with a family history of alcoholism (FHP) show less of a response to alcohol (e.g. lower ratings of intoxication) than males without a family history of alcoholism (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitiv...

journal_title：Psychopharmacology

authors： Evans SM,Levin FR

更新日期：2003-08-01 00:00:00

abstract：RATIONALE:Research on the effects of nicotine abstinence and nicotine replacement has not provided consistent information about the impact of replacement therapies on tobacco withdrawal and craving. OBJECTIVE:. This study investigated craving and withdrawal symptoms over a 72-h period of abstinence from cigarettes. M...

journal_title：Psychopharmacology

authors： Teneggi V,Tiffany ST,Squassante L,Milleri S,Ziviani L,Bye A

更新日期：2002-11-01 00:00:00

abstract：:Nefiracetam is undergoing preclinical and clinical tests as a cognition-enhancing drug in Alzheimer's disease (AD). Nicotinic cholinergic receptors are lost in AD, and nicotinic as well as muscarinic cholinergic receptors are involved in the modulation of eyeblink conditioning. Experiments were carried out using young...

journal_title：Psychopharmacology

authors： Woodruff-Pak DS,Hinchliffe RM

更新日期：1997-05-01 00:00:00

abstract：:The effects of acutely or chronically administered carbamazepine were studied in rats submitted to the modified Geller-Seifter conflict test. Diazepam was used as a standard anxiolytic. The results showed an increase in punished response after carbamazepine, as observed with diazepam, leading to the suggestion of an a...

journal_title：Psychopharmacology

authors： Almeida RN,Leite JR

更新日期：1990-01-01 00:00:00

abstract：:DL-2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed to quantify sniffing...

journal_title：Psychopharmacology

authors： Schmidt WJ

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Training in research ethics is crucial for psychiatric investigators. Addressing ethical dimensions of human subjects research requires knowledge about the rules and norms governing research; sensitivity to ethical implications of actions; and skills in ethics problem solving. Investigators in training who ar...

journal_title：Psychopharmacology

authors： Chen DT

更新日期：2003-12-01 00:00:00

abstract：:Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...

journal_title：Psychopharmacology

authors： Weiner I,Feldon J,Ben-Horin E

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...

journal_title：Psychopharmacology

authors： Pelloux Y,Everitt BJ,Dickinson A

更新日期：2007-09-01 00:00:00

abstract：RATIONALE:Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules. OBJ...

journal_title：Psychopharmacology

authors： Cheung TH,Bezzina G,Asgari K,Body S,Fone KC,Bradshaw CM,Szabadi E

更新日期：2006-04-01 00:00:00

abstract：:The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of ...

journal_title：Psychopharmacology

authors： Molander L,Randrup A

更新日期：1976-09-17 00:00:00

abstract：RATIONALE:Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (...

journal_title：Psychopharmacology

authors： Petrie GN,Wills KL,Piscitelli F,Smoum R,Limebeer CL,Rock EM,Humphrey AE,Sheppard-Perkins M,Lichtman AH,Mechoulam R,Di Marzo V,Parker LA

更新日期：2019-09-01 00:00:00

abstract：:We investigated the possibility that repeated electrical stimulation of the basolateral amygdala (kindling) would increase punished behavior, a pre-clinical indicator of anti-anxiety activity. Male Sprague-Dawley rats, prepared with electrodes in the left basolateral nucleus and frontal cortex, were trained to bar-pre...

journal_title：Psychopharmacology

authors： Witkin JM,Lee MA,Walczak DD

更新日期：1988-01-01 00:00:00

abstract：:We examined whether any locus postsynaptic to the GABAergic striatonigral projection might be involved in the enhancement of behavioral response to dopaminergic stimulants induced by chronic treatment with either neuroleptic drugs or stimulants. Rats exposed chronically to either chlorpromazine or cocaine were tested ...

journal_title：Psychopharmacology

authors： Bachus SE,Gale K

更新日期：1988-01-01 00:00:00

abstract：:Normal male volunteers took single acute doses of either diazepam or placebo under double-blind conditions in three simulated public speaking experiments. Measures of palmar sweating and subjective anxiety showed that anticipation of speaking in public increased anxiety relative to baseline and prestress conditions, a...

journal_title：Psychopharmacology

authors： McNair DM,Frankenthaler LM,Czerlinsky T,White TW,Sasson S,Fisher S

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Alzheimer's disease (AD) is characterized by memory loss and synaptic damage. Previous studies suggested that xanthoceraside decreases glutamate-induced PC12 cell death, ameliorates memory deficits, and increases the number of dendritic spines in AD mice. These results indicated that xanthoceraside might have...

journal_title：Psychopharmacology

authors： Zhu L,Yang L,Zhao X,Liu D,Guo X,Liu P,Chi T,Ji X,Zou L

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in p...

journal_title：Psychopharmacology

authors： Bradberry CW

更新日期：2002-12-01 00:00:00

abstract：:In order to study the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy. The EEG changes induced by apomorphine administration in comparison to those elic...

journal_title：Psychopharmacology

authors： Del Zompo M,Tocco F,Marrosu F,Passino N,Corsini GU

更新日期：1983-01-01 00:00:00

abstract：:Three adult baboons were trained using a psychophysical procedure to discriminate between different synthetic vowel sounds [symbol: see text]. Baboons pressed and held a lever down to produce a pulsed train of a single reference vowel that served as the standard stimulus. Animals were trained to release the lever only...

journal_title：Psychopharmacology

authors： Hienz RD,Spear DJ,Pyle DA,Brady JV

更新日期：1995-11-01 00:00:00

abstract：:The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...

journal_title：Psychopharmacology

authors： Devenport LD,Hale RL

更新日期：1989-01-01 00:00:00

abstract：:In the present pilot study, an attempt was made to shape and maintain cigarette smoking behavior in rhesus monkeys both with and without the simultaneous use of other reinforcers. Initially, 14 monkeys were trained to suck air and puff on cigarettes using sweetened liquid reinforcer. After smoking had been established...

journal_title：Psychopharmacology

authors： Ando K,Yanagita T

更新日期：1981-01-01 00:00:00

abstract：:This was a 4-week, three-center, double-blind, randomized, parallel, placebo-controlled evaluation of the efficacy and safety of bupropion in hospitalized depressed patients. Results from 27 placebo and 48 bupropion-treated patients were analyzed for efficacy and safety. Assessments of efficacy and safety were made at...

journal_title：Psychopharmacology

authors： Zung WW,Brodie HK,Fabre L,McLendon D,Garver D

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...

journal_title：Psychopharmacology

authors： Roberts AJ,Casal L,Huitron-Resendiz S,Thompson T,Tarantino LM

更新日期：2018-04-01 00:00:00

abstract：:This study evaluated the effects of two central nicotinic-cholinergic receptor agonists and an antagonist on performance accuracy of a rat, delayed stimulus discrimination task (DSDT). Rats were trained to discriminate between an auditory and visual stimulus by pressing a right or left lever. To diminish the rat's abi...

journal_title：Psychopharmacology

authors： Terry AV Jr,Buccafusco JJ,Jackson WJ,Zagrodnik S,Evans-Martin FF,Decker MW

更新日期：1996-01-01 00:00:00