Kappa opioids and the modulation of pain.

abstract：:Dopaminergic behavioral supersensitivity may be induced by chronic treatment with either dopaminergic agonists or antagonists. We demonstrate that the development of agonist-induced supersensitivity is resistant to chronic lithium exposure. Furthermore, chronic lithium alone enhances the stereotypic response to acute ...

journal_title：Psychopharmacology

authors： Rubin EH,Wooten GF

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...

journal_title：Psychopharmacology

authors： Jensen KP,Valentine G,Gueorguieva R,Sofuoglu M

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...

journal_title：Psychopharmacology

authors： Duxon MS,Stretton J,Starr K,Jones DN,Holland V,Riley G,Jerman J,Brough S,Smart D,Johns A,Chan W,Porter RA,Upton N

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated. OBJECTIVES:We examined the ingestive behavioral effects of MTII at the microstructural level using two complementary approaches. METHODS...

journal_title：Psychopharmacology

authors： Williams DL,Grill HJ,Weiss SM,Baird JP,Kaplan JM

更新日期：2002-04-01 00:00:00

abstract：:Monoamine oxidases A and B (MAO-A and B) catalyze the oxidative catabolism of biogenic amines and xenobiotics. Investigation of these mitochondrial membrane proteins shows that they differ in substrate preference, inhibitor specificity, tissue and neuronal cell distribution, immunological properties, and nucleotide an...

journal_title：Psychopharmacology

authors： Kwan SW,Bergeron JM,Abell CW

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Neurobiological models of addiction suggest that abnormalities of brain reward circuitry distort salience attribution and inhibitory control processes, which in turn contribute to high relapse rates. OBJECTIVES:The aim of this study is to determine whether impairments of salience attribution and inhibitory c...

journal_title：Psychopharmacology

authors： Powell J,Dawkins L,West R,Powell J,Pickering A

更新日期：2010-12-01 00:00:00

abstract：:Central dopaminergic transmission has been implicated in memory processes. The present experiments examined the effects of several direct acting dopaminergic agents on performance of a delayed-non-match-to-sample radial arm maze task. Preadministration of apomorphine (D1-D2 agonist; 0.25, 0.5, and 1.0 mg/kg), quinpiro...

journal_title：Psychopharmacology

authors： Chrobak JJ,Napier TC

更新日期：1992-01-01 00:00:00

abstract：:Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse e...

journal_title：Psychopharmacology

authors： Yisak W,Farde L,von Bahr C,Nilsson LB,Fredriksson G,Ogenstad S

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Preclinical studies indicate that gonadal hormones are important determinants of drug self-administration. To date, little is known about the influence of sex and estrous cycle on drug self-administration in ecologically relevant social contexts. OBJECTIVE:The objective of this study was to examine the role ...

journal_title：Psychopharmacology

authors： Lacy RT,Strickland JC,Feinstein MA,Robinson AM,Smith MA

更新日期：2016-09-01 00:00:00

abstract：:Rats were trained to bar-press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of morphine self-administration were enhanced by lesions of the frontal cortex and hippocampus and transiently reduced by lesions of the medial forebrain bundle and medial thalamus. Dose-response studies ...

journal_title：Psychopharmacology

authors： Glick SD,Cox RD

更新日期：1978-05-31 00:00:00

abstract：:The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...

journal_title：Psychopharmacology

authors： Havemann U,Magnus B,Möller HG,Kuschinsky K

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Preclinical evidence suggests that non-cannabinoid neurotransmitter systems are involved in the behavioral and physiological effects of cannabinoids, but relatively little research has been conducted in humans. OBJECTIVES:The aims of this study were to assess whether oral Delta(9)-tetrahydrocannabinol (Delta...

journal_title：Psychopharmacology

authors： Lile JA,Kelly TH,Pinsky DJ,Hays LR

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Salvinorin A is the active component of the hallucinogenic plant Salvia divinorum. The potential mode of action of this hallucinogen was unknown until recently. A recent in vitro study detected high affinity and efficacy of salvinorin A at kappa-opioid receptors. It was postulated that salvinorin A would prod...

journal_title：Psychopharmacology

authors： Butelman ER,Harris TJ,Kreek MJ

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds. OBJECTIVES:To replicate previous studies in subjects with MDD who had been drug free for a...

journal_title：Psychopharmacology

authors： Porter RJ,Gallagher P,Watson S,Smith MS,Young AH

更新日期：2003-08-01 00:00:00

abstract：:There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days wit...

journal_title：Psychopharmacology

authors： Bjartmar L,Johansson IM,Marcusson J,Ross SB,Seckl JR,Olsson T

更新日期：2000-07-01 00:00:00

abstract：:Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...

journal_title：Psychopharmacology

authors： Gerlach J,Christensen JK,Christensen TL,Elley J,Jensen JP,Larsen SB

更新日期：1987-01-01 00:00:00

abstract：:Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...

journal_title：Psychopharmacology

authors： Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear. OBJECTIVES:To determine the effects of chronic buprenorphine treatment on intake of heroin and/or cocaine and measure nucleus accumbens (NAc) dopamine (DA) levels during self-administration. METHODS:In...

journal_title：Psychopharmacology

authors： Sorge RE,Stewart J

更新日期：2006-09-01 00:00:00

abstract：:There is much evidence suggesting that the mesoamygdala dopaminergic (DAergic) system plays a crucial role in the formation and expression of fear conditioning, with both D1 and D2 receptors being involved. In addition, cannabinoid CB1 receptor (CB1R) signaling modulates DAergic pathways. The present study sought to d...

journal_title：Psychopharmacology

authors： Nasehi M,Hajian M,Ebrahimi-Ghiri M,Zarrindast MR

更新日期：2016-01-01 00:00:00

abstract：:A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and...

journal_title：Psychopharmacology

authors： Gentil V,McCurdy RL,Alevizos B,Lader MH

更新日期：1976-11-10 00:00:00

abstract：:To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/r...

journal_title：Psychopharmacology

authors： Francis RL,Cooper SJ

更新日期：1979-06-21 00:00:00

abstract：RATIONALE:Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularl...

journal_title：Psychopharmacology

authors： Janetsian SS,Linsenbardt DN,Lapish CC

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Casein kinase I epsilon/delta phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional/translational feedback loops that comprise the circadian oscillator in mammals. Pharmacologic inhibition leads to a delay of the oscillations with the magnitude of this effect dep...

journal_title：Psychopharmacology

authors： Sprouse J,Reynolds L,Kleiman R,Tate B,Swanson TA,Pickard GE

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...

journal_title：Psychopharmacology

authors： Langleben DD,Busch EL,O'Brien CP,Elman I

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:The extent to which non-α4β2 versus α4β2* nAChRs contribute to the behavioral effects of varenicline and other nAChR agonists is unclear. OBJECTIVES:The purpose of this study was to characterize the discriminative stimulus effects of varenicline and nicotine using various nAChR agonists and antagonists to el...

journal_title：Psychopharmacology

authors： de Moura FB,McMahon LR

更新日期：2017-03-01 00:00:00

abstract：:Chronic administration of the pre-synaptic alpha-adrenoreceptor agonist clonidine decreases the concentration of the extra-neuronal metabolite of noradrenaline normetanephrine in the amygdaloid cortex and increases it in the mid-brain. Conversely, blockade of these pre-synaptic receptors by yohimbine increases the nor...

journal_title：Psychopharmacology

authors： Fludder JM,Leonard BE

更新日期：1979-09-01 00:00:00

abstract：RATIONALE:The notion that the onset of action of antidepressant drugs (ADs) takes weeks is widely accepted; however, the sequence of events necessary for therapeutic effects still remains obscure. OBJECTIVE:We aimed to evaluate a time-course of ADs-induced alterations in the expression of 95 selected genes in 4 region...

journal_title：Psychopharmacology

authors： Gąska M,Kuśmider M,Solich J,Faron-Górecka A,Krawczyk MJ,Kułakowski K,Dziedzicka-Wasylewska M

更新日期：2012-10-01 00:00:00

abstract：:Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantl...

journal_title：Psychopharmacology

authors： Brown SL,Charney DS,Woods SW,Heninger GR,Tallman J

更新日期：1988-01-01 00:00:00

abstract：:The anorectic activity of the d and l isomers of d-fenfluramine (d-FF) (l-FF) were compared with d-amphetamine (d-amp) when given separately and together in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser. Anorectic activity was ...

journal_title：Psychopharmacology

authors： Goodall E,Feeney S,McGuirk J,Silverstone T

更新日期：1992-01-01 00:00:00

abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

journal_title：Psychopharmacology

authors： Singh PP,Das PK

更新日期：1978-04-11 00:00:00