Noradrenergic and behavioural effects of naloxone injected in the locus coeruleus of morphine-dependent rats and their control by clonidine.

abstract：:Previous studies indicate that some aspects of endotoxin-induced sickness behavior in rats may be mediated by interleukin-1 stimulated events and can be attenuated by corticosteroids, cyclooxygenase inhibitors and the interleukin-1-receptor antagonist. In the current studies, we replicate and extend these findings in ...

journal_title：Psychopharmacology

authors： Fishkin RJ,Winslow JT

更新日期：1997-08-01 00:00:00

abstract：:In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...

journal_title：Psychopharmacology

authors： Santori EM,Schmidt DE,Kalivas PW,Horita A

更新日期：1981-01-01 00:00:00

abstract：:SCH 39166 is the first selective D1-dopamine receptor antagonist developed for clinical trials in schizophrenia. SCH 39166 was evaluated as a radioligand for PET, labeled with 11C, and as a D1-dopamine receptor antagonist after single oral doses in healthy men. After intravenous injection of [11C]SCH 39166 distributio...

journal_title：Psychopharmacology

authors： Karlsson P,Sedvall G,Halldin C,Swahn CG,Farde L

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...

journal_title：Psychopharmacology

authors： Mumenthaler MS,O'Hara R,Taylor JL,Friedman L,Yesavage JA

更新日期：2001-05-01 00:00:00

abstract：:The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...

journal_title：Psychopharmacology

authors： Ritz MC,George FR

更新日期：1997-02-01 00:00:00

abstract：:The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement wa...

journal_title：Psychopharmacology

authors： Glue PW,Cowen PJ,Nutt DJ,Kolakowska T,Grahame-Smith DG

更新日期：1986-01-01 00:00:00

abstract：:Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with systemic injections of AMPH does produce a significant enhancement in the locomotor stimulant effec...

journal_title：Psychopharmacology

authors： Paulson PE,Robinson TE

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...

journal_title：Psychopharmacology

authors： Kalinichev M,Rourke C,Daniels AJ,Grizzle MK,Britt CS,Ignar DM,Jones DN

更新日期：2005-10-01 00:00:00

abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...

journal_title：Psychopharmacology

authors： Tran S,Nowicki M,Muraleetharan A,Gerlai R

更新日期：2015-02-01 00:00:00

abstract：:The purpose of this study was to determine whether repeated treatment (15 days) with d-amphetamine (AMP) or fenfluramine (FEN), administered after a daily 3 h feeding session (e.g. post-session), would result in tolerance or cross-tolerance to the decrement in food consumption induced by treatment with either drug bef...

journal_title：Psychopharmacology

authors： Hunsinger RN,Barnes TB,Kapeghian JC,Wilson MC

更新日期：1981-01-01 00:00:00

abstract：:Rats were trained to self-stimulate by interrupting a photobeam and brain stimulation was maintained for as long as the beam of light was broken. d-Amphetamine sulphate was then administered and response rate and total duration of stimulation were recorded. Both response rate and total duration were elevated by 1.0, 2...

journal_title：Psychopharmacology

authors： Zacharko RM,Wishart TB

更新日期：1979-08-08 00:00:00

abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...

journal_title：Psychopharmacology

authors： Grottick AJ,Whelan K,Sanabria EK,Behan DP,Morgan M,Sage C

更新日期：2015-06-01 00:00:00

abstract：:Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...

journal_title：Psychopharmacology

authors： Weiner I,Feldon J,Ben-Horin E

更新日期：1987-01-01 00:00:00

abstract：:A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood a...

journal_title：Psychopharmacology

authors： Radlow R

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...

journal_title：Psychopharmacology

authors： Linn GS,Lifshitz K,O'Keeffe RT,Lee K,Camp-Lifshitz J

更新日期：2001-01-01 00:00:00

abstract：:MA rats, bred for greater motor impairment following subhypnotic doses of ethanol, were found to be more sensitive to the hypnotic effects of phenobarbital and chloral hydrate than were LA rats. In addition, the previously reported finding of a difference between the two lines of rats in duration of loss of righting r...

journal_title：Psychopharmacology

authors： Riley EP,Shapiro NR,Lochry EA

更新日期：1979-02-28 00:00:00

abstract：RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...

journal_title：Psychopharmacology

authors： Gunes A,Scordo MG,Jaanson P,Dahl ML

更新日期：2007-03-01 00:00:00

abstract：RATIONALE:The aversive effects of ∆(9)-tetrahydrocannabinol (THC) are mediated by activity at the kappa opioid receptor (KOR) as assessed in adult animals; however, no studies have assessed KOR involvement in the aversive effects of THC in adolescents. Given that adolescents have been reported to be insensitive to the ...

journal_title：Psychopharmacology

authors： Flax SM,Wakeford AG,Cheng K,Rice KC,Riley AL

更新日期：2015-09-01 00:00:00

abstract：:We investigated the possible role of dopamine receptors in the mediation of copulatory disorder induced by defeat experience in male mice, using L-dopa and apomorphine. To generate the copulatory disorder, male mice were attacked 20 times daily for 5 consecutive days, as intruders in confrontation with an aggressive r...

journal_title：Psychopharmacology

authors： Sugiura K,Yoshimura H,Yokoyama M

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:Converging evidence suggests that dopaminergic and serotonergic mechanisms affect distinct aspects of cognitive performance. Experiments using the rodent five-choice reaction time task have established a critical role for dopaminergic mechanisms in the rat medial prefrontal cortex (mPFC), but have yielded onl...

journal_title：Psychopharmacology

authors： Passetti F,Dalley JW,Robbins TW

更新日期：2003-01-01 00:00:00

abstract：:Administration of 10 mg/kg TRH to mice was found to reduce the sleep and hypothermia induced by 4.7 g/kg ethanol. However, TRH did not reduce the sleep of mice that were given gamma-hydroxybutyric acid (GHBA), baclophen, or aminooxyacetic acid (AOAA) in combination with 3 g/kg/ ethanol. TRH also failed to reverse the ...

journal_title：Psychopharmacology

authors： Cott J,Engel J

更新日期：1977-04-29 00:00:00

abstract：RATIONALE:Gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. Sex differences have also been observed in the antinociceptive effects of opioid agonis...

journal_title：Psychopharmacology

authors： Negus SS,Mello NK

更新日期：2002-01-01 00:00:00

abstract：:The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...

journal_title：Psychopharmacology

authors： Turski L,Turski W,Czuczwar SJ,Kleinrok Z

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:In an animal model for vulnerability to drug abuse, rats that are more reactive to a novel environment (high responders, HRs) are more sensitive to behavioral effects of psychostimulants than are less reactive rats (low responders, LRs). In a companion article, we reported that HRs and LRs differ in sensitivi...

journal_title：Psychopharmacology

authors： White DA,Kalinichev M,Holtzman SG

更新日期：2004-12-01 00:00:00

abstract：:We examined whether any locus postsynaptic to the GABAergic striatonigral projection might be involved in the enhancement of behavioral response to dopaminergic stimulants induced by chronic treatment with either neuroleptic drugs or stimulants. Rats exposed chronically to either chlorpromazine or cocaine were tested ...

journal_title：Psychopharmacology

authors： Bachus SE,Gale K

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of...

journal_title：Psychopharmacology

authors： Romieu P,Meunier J,Garcia D,Zozime N,Martin-Fardon R,Bowen WD,Maurice T

更新日期：2004-09-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Footshock stress reliably reinstates heroin seeking in rats, but the time course of the development of this effect following drug withdrawal is not known. Here we studied the effect of intermittent footshock stress on reinstatement of heroin seeking following different withdrawal periods (1-66 ...

journal_title：Psychopharmacology

authors： Shalev U,Morales M,Hope B,Yap J,Shaham Y

更新日期：2001-06-01 00:00:00

abstract：RATIONALE:Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) pro...

journal_title：Psychopharmacology

authors： Madsen K,Erritzoe D,Mortensen EL,Gade A,Madsen J,Baaré W,Knudsen GM,Hasselbalch SG

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...

journal_title：Psychopharmacology

authors： Hassani S,Alipour A,Darvishi Khezri H,Firouzian A,Emami Zeydi A,Gholipour Baradari A,Ghafari R,Habibi WA,Tahmasebi H,Alipour F,Ebrahim Zadeh P

更新日期：2015-03-01 00:00:00

abstract：RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...

journal_title：Psychopharmacology

authors： Lew R,Constantinescu CC,Holden D,Carson RE,Carroll V,Galluppi G,Koblan KS,Hopkins SC

更新日期：2020-11-01 00:00:00