Abstract：
:Nicotine (0.16--0.50 mg/kg, SC) was found to exert a potent antinociceptive action on thermal stimuli as measured by the tail-flick test. This antinociceptive action of nicotine could be blocked by centrally active nicotinic or muscarinic blockers implicating both classes of cholinergic receptors in this effect. Quaternary blockers, however, failed to prevent nicotine-induced antinociception. This finding, together with the ability of small doses of nicotine (25 micrograms) to induce potent antinociceptive effects when administered centrally, suggests a central site of action for the antinociceptive action of nicotine. The present results also support the suggestion that nicotine may selectively reduce sensitivity to certain classes of pain stimuli, perhaps through a central releasing action on acetylcholine.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Sahley TL,Berntson GGdoi
10.1007/BF00492216subject
Has Abstractpub_date
1979-11-01 00:00:00pages
279-83issue
3eissn
0033-3158issn
1432-2072journal_volume
65pub_type
杂志文章abstract：RATIONALE:Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapse OBJECTIVE:This present study was designed to investigate the potential role for the HPA axis in the cue- and methamphetamine-i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0625-7
更新日期：2007-02-01 00:00:00
abstract：RATIONALE:The positive modulation of gamma-aminobutyric acid type-A (GABAA) receptors is a putative mechanism via which alcohol escalates aggressive behavior. Broad-spectrum benzodiazepine antagonists block alcohol-heightened aggression in rats and monkeys. However, the degree to which GABAA subunit composition plays a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1661-1
更新日期：2004-03-01 00:00:00
abstract：RATIONALE:Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy or attention deficit disorders and to enhance vigilance in sleep-deprived military personal. So far, understanding of the cognitive enhancing effects of modafinil and the relevant neu...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-004-1926-3
更新日期：2004-12-01 00:00:00
abstract：:The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00426651
更新日期：1980-01-01 00:00:00
abstract：:The effects of benztropine, scopolamine, atropine, methylatropine, amitriptyline, phencyclidine, and meperidine were determined alone and in conjunction with a behaviorally suppressing dose (0.05 mg/kg IM) of oxotremorine in pigeons responding under a multiple fixed-ratio 30 fixed-interval 5-min schedule of grain pres...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433492
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05758-8
更新日期：2021-01-29 00:00:00
abstract：INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4657-y
更新日期：2017-08-01 00:00:00
abstract：RATIONALE:A previous study found that a 10-min bout of moderate intensity exercise reduced cigarette withdrawal symptoms and desire to smoke in sedentary smokers but the effect may have been due to participants focusing attention on physical activity rather than the activity itself. OBJECTIVES:This study examined the ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-003-1762-x
更新日期：2004-07-01 00:00:00
abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3610-6
更新日期：2014-12-01 00:00:00
abstract：:The effects of long-term amphetamine treatment were evaluated on responding supported by self-stimulation of the substantia nigra. Rats repeatedly treated with d-amphetamine, and tested with a low dose of the drug that ordinarily has no behavioral effect, showed higher response rates than animals repeatedly treated wi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426653
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Severe, traumatic stress or repeated exposure to stress can result in long-term deleterious effects, including hippocampal cell atrophy and death, which, in turn, result in memory impairments and behavioural abnormalities. The dopaminergic D(2) receptor agonist, bromocriptine, has been shown to modulate learn...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0801-4
更新日期：2007-08-01 00:00:00
abstract：RATIONALE:The amygdala and insular cortex are integral to the processing of emotionally salient stimuli. We have shown in healthy volunteers that an anxiolytic agent, lorazepam, dose-dependently attenuates activation of limbic structures. OBJECTIVE:The current study investigated whether administration of a selective s...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-007-1004-8
更新日期：2008-03-01 00:00:00
abstract：RATIONALE:Salvinorin A, the primary psychoactive derivative of the hallucinogenic herb Salvia divinorum, is a potent and highly selective kappa-opioid receptor (KOR) agonist. Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects. OBJECTIVES:This study represents a syst...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1827-6
更新日期：2010-06-01 00:00:00
abstract：:It has been suggested that anxiety may be a critical factor in certain forms of non-opioid environmental analgesia. In the present study, 5-min exposure to the elevated plus-maze test of anxiety (EPM) induced a mild, though enduring, elevation in tail-flick latencies in male mice. Pretreatment with the opiate antagoni...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247133
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Convergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between the amygdala and the prefrontal cortex (PFC), alcohol's effects are likely to extend beyond regional ch...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-013-3090-0
更新日期：2013-09-01 00:00:00
abstract：:Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s002130050320
更新日期：1997-07-01 00:00:00
abstract：:The asymptomatic and clinical stages of Parkinson's disease (PD) are associated with comorbid non-motor symptoms including gastrointestinal (GI) dysfunction. Although the neuroprotective and gastroprotective roles of kolaviron (KV) have been reported independently, whether KV-mediated GI-protective capacity could be b...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05605-w
更新日期：2020-11-01 00:00:00
abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100686
更新日期：2001-04-01 00:00:00
abstract：RATIONALE:Functional interactions between limbic regions that process emotions and frontal networks that guide response functions provide a substrate for emotional cues to influence behavior. Stimulation of postsynaptic α₂ adrenoceptors enhances the function of prefrontal regions in these networks. However, the impact ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-012-2893-8
更新日期：2013-03-01 00:00:00
abstract：RATIONALE:Control of reward-seeking behavior under conditions of punishment is an important function for survival. OBJECTIVES AND METHODS:We designed a task in which rats could choose to either press a lever and obtain a food pellet accompanied by a footshock or refrain from pressing the lever to avoid footshock, in r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05398-7
更新日期：2020-03-01 00:00:00
abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2527-6
更新日期：2012-04-01 00:00:00
abstract：:Two putative predictors of placebo response were studied in three samples of psychiatric outpatients. Two groups, 73 university medical center patients and 56 college health service patients, underwent 1 week of placebo treatment. A quasi-control group of 112 patients receiving no medication waited about 1 week before...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00433557
更新日期：1979-06-21 00:00:00
abstract：RATIONALE:An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and imp...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3542-1
更新日期：2014-10-01 00:00:00
abstract：RATIONALE:Stressful life events are suggested to contribute to the development of various pathologies, such as cardiovascular disorders, whose etiopathogenesis is highly associated with elevated levels of serum amyloid A (SAA) proteins. SAA synthesis in the liver is regulated by a complex network of cytokines acting in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5149-4
更新日期：2019-06-01 00:00:00
abstract：RATIONALE:The C57BL/6 is one of the most widely used mouse strains in behavioral, pharmacological, and genetic research but little is known about their response on tests for antidepressant drugs. OBJECTIVES:The behavior of C57BL/6 mice, and mice from other strains, was examined in the tail suspension test (TST), a com...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100687
更新日期：2001-04-01 00:00:00
abstract：RATIONALE:Alcohol intoxication can dampen negative affective reactions to stressors. Recently, it has been proposed that these acute anxiolytic effects of alcohol may extend to dampening of negative affective reactions to error commission during cognitive control tasks. Nonetheless, empirical verification of this claim...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05619-4
更新日期：2020-11-01 00:00:00
abstract：RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1526-3
更新日期：2009-07-01 00:00:00
abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174701
更新日期：1988-01-01 00:00:00
abstract：:The fatty acid specificity of the depressant actions associated with prostaglandin (PG) administration was studied in mice. Administration of PG-E2 (0.4 and 1.0 mg/kg) or PG-D2 (0.4 and 4 mg/kg) significantly potentiated pentobarbital sleeping time. Arachidonic acid (3.3 mg/kg) administration also significantly potent...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00555225
更新日期：1984-01-01 00:00:00
abstract：:Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245234
更新日期：1994-01-01 00:00:00
