Abstract：
:Risperidone was studied in a 0.16 mg/kg LSD-saline drug discrimination test procedure. At doses varying from 0.0025 to 0.63 mg/kg, no LSD-like agonist effects were observed. Studies on the antagonism of the LSD-cue indicated that risperidone was able to completely block the discriminative stimulus properties of LSD with a minimum ED50-value of 0.028 mg/kg. Risperidone was also very active over time with reference to LSD antagonism, the ED50S after 2, 4 and 8 h pretreatment being 0.028, 0.064 and 0.44 mg/kg. Response rate reductions were only observed at doses greater than or equal to 0.16 mg/kg after 1 h and at 0.63 mg/kg after 2 h pretreatment. Four and 8 h after treatment, no rate-reducing effects were apparent at doses up to 2.50 mg/kg. Thus at pretreatment intervals ranging between 2 and 8 h, complete antagonism of LSD without any rate effects was obtained. As compared to other LSD antagonists, risperidone was quantitatively better than setoperone and ritanserin and longer acting than pirenperone. Based on the pharmacological profile of risperidone and the other LSD antagonists, it was concluded that a potent central 5-HT2 and catecholamine antagonism is needed for a potent and complete antagonism of the 0.16 mg/kg LSD-cue. The potential clinical effect of risperidone in the positive and negative symptoms of schizophrenia is discussed.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Meert TF,de Haes P,Janssen PAdoi
10.1007/BF00442251subject
Has Abstractpub_date
1989-01-01 00:00:00pages
206-12issue
2eissn
0033-3158issn
1432-2072journal_volume
97pub_type
杂志文章abstract：:The purpose of this study was to determine whether repeated treatment (15 days) with d-amphetamine (AMP) or fenfluramine (FEN), administered after a daily 3 h feeding session (e.g. post-session), would result in tolerance or cross-tolerance to the decrement in food consumption induced by treatment with either drug bef...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00435853
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:Caffeine is commonly believed to offset the acute effects of alcohol, but some evidence suggests that cognitive processes remain impaired when caffeine and alcohol are coadministered. OBJECTIVES:No previous study has investigated the separate and joint effects of alcohol and caffeine on conflict monitoring a...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4208-y
更新日期：2016-04-01 00:00:00
abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA) produces a long-term depletion of serotonin (5-HT) in the rat brain; this depletion may have some functional consequences. OBJECTIVE:The aim of the present study was to evaluate the acute effects of MDMA on the extracellular concentrations of dopamine and 5-HT, body t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051143
更新日期：1999-11-01 00:00:00
abstract：:A simple new method, the "tape test" has been developed for studying the enhancement of learning by drugs in "learning-dull" rats. A piece of adhesive tape is pressed on the left front pad of the rats. The time of tape removal by the animal, i.e., the problem-solving time is measured. In our experiments the selected l...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00423313
更新日期：1976-07-09 00:00:00
abstract：:A total of 97 patients, who participated in two studies on the relationship between the clinical effect and plasma levels of imipramine and clomipramine, were examined for improvement curves by use of weekly ratings on the Hamilton Depression Scale (HDS). Although we confirmed that our six-item HDS subscale, in contra...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00427459
更新日期：1984-01-01 00:00:00
abstract：:Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244602
更新日期：1990-01-01 00:00:00
abstract：:Tolerance to nicotine occurs in mice after its chronic administration. This tolerance is accompanied by an up-regulation of nicotinic receptors as assessed by the binding of (3H)-nicotine and alpha-(125I)-bungarotoxin (BTX). Past studies (Marks et al. 1983, 1986) have shown that the increase in BTX binding sites is mo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00212766
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-017-4665-y
更新日期：2017-09-01 00:00:00
abstract：RATIONALE:Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic-pituitary-adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, compounds that block the effects of stress hormones were investigated as potential therapeu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-2164-z
更新日期：2005-07-01 00:00:00
abstract：:Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427800
更新日期：1983-01-01 00:00:00
abstract：:Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432038
更新日期：1984-01-01 00:00:00
abstract：:The in vivo potency of mazindol for binding to striatal dopamine transporters (DAT) was assessed by [123I]beta-CIT ([123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n = 12) underwent three SPECT scans; one before, between, and after s...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130050625
更新日期：1998-06-01 00:00:00
abstract：:Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00215480
更新日期：1987-01-01 00:00:00
abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174701
更新日期：1988-01-01 00:00:00
abstract：:Nefiracetam is undergoing preclinical and clinical tests as a cognition-enhancing drug in Alzheimer's disease (AD). Nicotinic cholinergic receptors are lost in AD, and nicotinic as well as muscarinic cholinergic receptors are involved in the modulation of eyeblink conditioning. Experiments were carried out using young...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050275
更新日期：1997-05-01 00:00:00
abstract：RATIONALE:A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. OBJECTIVE:To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130051111
更新日期：1999-09-01 00:00:00
abstract：:Chlordiazepoxide (CDP) and amphetamine (AMPH) were tested, alone or in combination, in BALB/c mice pretreated with alpha-methyl-p-tyrosine (AMT) and subjected to shuttle-box avoidance training. CDP and AMPH, given alone, partly reversed avoidance depression induced by 50 mg/kg of AMT, but were ineffective in mice pret...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433495
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:The social interaction test is a valuable behavioural model for testing anxiolytic drugs in rodents, quantifying the level of social behaviour between pairs of rats. OBJECTIVE:The aim of the present study was to assess the appropriateness of the social interaction test for use with a Sprague-Dawley rat line,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1914-7
更新日期：2004-12-01 00:00:00
abstract：RATIONALE:Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well. OBJECTIVE:The aim of the study was to evaluate learning and working memory...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-010-1963-z
更新日期：2010-10-01 00:00:00
abstract：:Cocaine and amphetamine produce several behavioral effects, most notably locomotor stimulation. Biochemically, evidence suggests specific involvement of dopaminergic systems, although not necessarily identical sites, in mediating cocaine- and amphetamine-induced locomotor stimulation. This study examined the effects o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245649
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Latent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaser amphetamine which produces and exacerbates psychotic (positive) symptoms, and this is reversed by treatment with typical and a...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1313-x
更新日期：2003-09-01 00:00:00
abstract：:The serotonin 5-HT(3) receptor is thought to play a role in the reward pathway and drug abuse by modulating dopamine release within the mesolimbic pathway. Dopamine release stimulated by cocaine and methamphetamine is blocked by administration of 5-HT(3) receptor antagonists. Animal studies demonstrate that 5-HT(3) re...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100833
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:Traumatic events are associated with alcohol use problems with increased alcohol craving as a potential mediator. There is still a lack of knowledge regarding the causal nature of this association and its underlying mechanisms. This study investigated the effects of acute trauma exposure on alcohol craving i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4979-4
更新日期：2018-10-01 00:00:00
abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100686
更新日期：2001-04-01 00:00:00
abstract：:Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02180028
更新日期：1988-01-01 00:00:00
abstract：:Patients taking lithium often report difficulties in concentration, memory, learning, and attention and many of these complaints are verified on psychometric testing. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning processes are apparent ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00427911
更新日期：1985-01-01 00:00:00
abstract：:A continuous intravenous infusion of the opiate receptor antagonist naloxone, at doses ranging from 0.7 to 1.0 micrograms/kg/min (total dose 8.8-13.2 mg), was performed in eight normal subjects during the first 240 min of night sleep. A significant reduction in stage REM and in stage 4 percent duration was observed. P...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00429731
更新日期：1984-01-01 00:00:00
abstract：:A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood a...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245438
更新日期：1994-02-01 00:00:00
abstract：:After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00207236
更新日期：1987-01-01 00:00:00
abstract：RATIONALE:Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibitio...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05434-6
更新日期：2020-04-01 00:00:00
