Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing.

abstract：:To investigate the role of D1 dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 mg/kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related in...

journal_title：Psychopharmacology

authors： Kleven MS,Anthony EW,Goldberg LI,Woolverton WL

更新日期：1988-01-01 00:00:00

abstract：:Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...

journal_title：Psychopharmacology

authors： Caligiuri MP,Lohr JB,Rotrosen J,Adler L,Lavori P,Edson R,Tracy K

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:Temporal differentiation in the free-operant psychophysical procedure is sensitive to the 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT2 receptor agonist 2,5-dimethoxy-4-iodo-amphetamine (DOI); both drugs shift the psychophysical curve leftwards...

journal_title：Psychopharmacology

authors： Body S,Kheramin S,Ho MY,Miranda Herrera F,Bradshaw CM,Szabadi E

更新日期：2004-11-01 00:00:00

abstract：:The behavioral performance of inbred mouse strains was examined in animal models of anxiety to evaluate the potential contribution of genetic factors to fear-motivated behaviors. The preference that randomly bred mice and rats exhibit for the enclosed as opposed to the open arms of an elevated maze has been considered...

journal_title：Psychopharmacology

authors： Trullas R,Skolnick P

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Several recent studies have focused on glutamate modulating agents for symptoms relief in schizophrenia, especially negative symptoms which are resistant to conventional therapies. OBJECTIVES:We aimed to assess the efficacy and tolerability of riluzole, an anti-glutamate agent with neuroprotective properties...

journal_title：Psychopharmacology

authors： Farokhnia M,Sabzabadi M,Pourmahmoud H,Khodaie-Ardakani MR,Hosseini SM,Yekehtaz H,Tabrizi M,Rezaei F,Salehi B,Akhondzadeh S

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...

journal_title：Psychopharmacology

authors： Nordquist RE,Vanderschuren LJ,Jonker AJ,Bergsma M,de Vries TJ,Pennartz CM,Voorn P

更新日期：2008-05-01 00:00:00

abstract：:Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). The incidence of predatory mouse killing was enhanced by 5,7-DHT, but was not affected by 6-OHdopa. Pain sensitivity ...

journal_title：Psychopharmacology

authors： Kantak KM,Hegstrand LR,Eichelman B

更新日期：1981-01-01 00:00:00

abstract：:The behavioral effects following intrastriatal MPP+, the neurotoxic metabolite of MPTP, were evaluated in mice. Bilateral injections of 10 micrograms MPP+ to mice previously trained in the shuttle box paradigm produced a 66% decrease in striatal dopamine and significant deficits in all measures of conditioned avoidanc...

journal_title：Psychopharmacology

authors： Wagner GC,Walsh SL

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...

journal_title：Psychopharmacology

authors： Peterson K,Dieperink E,Anderson J,Boundy E,Ferguson L,Helfand M

更新日期：2017-06-01 00:00:00

abstract：RATIONALE:Quitting smoking is often very challenging, leading to frequent relapse. Exposure to acute and chronic stress during abstinence increases the likelihood of relapse to smoking. In rodents, stress acutely reinstates nicotine seeking after extinction of nicotine self-administration (SA). However, whether reacqui...

journal_title：Psychopharmacology

authors： Yu G,Chen H,Sharp BM

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (...

journal_title：Psychopharmacology

authors： Petrie GN,Wills KL,Piscitelli F,Smoum R,Limebeer CL,Rock EM,Humphrey AE,Sheppard-Perkins M,Lichtman AH,Mechoulam R,Di Marzo V,Parker LA

更新日期：2019-09-01 00:00:00

abstract：RATIONALE:Recent findings have shown a complexly regulated 5-HT system as it is linked to different kinds of aggression. OBJECTIVE:We focus on (1) phasic and tonic changes of 5-HT and (2) state and trait of aggression, and emphasize the different receptor subtypes, their role in specific brain regions, feed-back regul...

journal_title：Psychopharmacology

authors： Takahashi A,Quadros IM,de Almeida RM,Miczek KA

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:The characterization of self-administration (SA) under extended access conditions is necessary for the development of addiction models. OBJECTIVE:The purposes of this experiment were to investigate: (1) dose effects on the initiation of cocaine SA under extended access conditions; (2) predictable individual ...

journal_title：Psychopharmacology

authors： Mantsch JR,Ho A,Schlussman SD,Kreek MJ

更新日期：2001-08-01 00:00:00

abstract：RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...

journal_title：Psychopharmacology

authors： Franklin AE,Engeland CG,Kavaliers M,Ossenkopp KP

更新日期：2003-12-01 00:00:00

abstract：:The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within ea...

journal_title：Psychopharmacology

authors： White NM,Packard MG,Hiroi N

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Stress experience during adolescence has been linked to the development of psychiatric disorders in adulthood, many of which are associated with impairments in prefrontal cortex function. OBJECTIVE:The current study was designed to determine the immediate and enduring effects of repeated social stress on a p...

journal_title：Psychopharmacology

authors： Snyder KP,Barry M,Valentino RJ

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while respondi...

journal_title：Psychopharmacology

authors： Cope ZA,Halberstadt AL,van Enkhuizen J,Flynn AD,Breier M,Swerdlow NR,Geyer MA,Young JW

更新日期：2016-10-01 00:00:00

abstract：:Young adult rats (5 months) were compared with aged (28 months) rats in their ability to learn and perform in a diazepam drug discrimination. Both groups of rats were drug naive at the onset of the experiment. Adult and aged animals learned to discriminate diazepam. In general, the response rates under both drug and v...

journal_title：Psychopharmacology

authors： Amrick CL,Bennett DA

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...

journal_title：Psychopharmacology

authors： Woolverton WL,Hecht GS,Agoston GE,Katz JL,Newman AH

更新日期：2001-04-01 00:00:00

abstract：:2,4-Dithiobiuret (DTB) is a sulfonated derivative of urea that is used as a reducing agent in chemical manufacture. Its low acute toxicity to rodents belies a peripherally mediated, delayed-onset muscle weakness which develops during repeated daily exposure. In experiment 1, a standard dose regimen of DTB (0.5 mg/kg p...

journal_title：Psychopharmacology

authors： Bushnell PJ,Oshiro WM

更新日期：1996-02-01 00:00:00

abstract：RATIONALE:Increasing concomitant abuse of cocaine and morphine-like opioids has prompted a number of studies aimed at understanding how these drugs interact. OBJECTIVE:The present study was designed to determine if variations in opioid pretreatment time would affect how mu opioid agonists interact with cocaine. METHO...

journal_title：Psychopharmacology

authors： Green-Jordan K,Warren L,Kantak KM

更新日期：2001-08-01 00:00:00

abstract：:The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...

journal_title：Psychopharmacology

authors： Rebec GV,White IM,Puotz JK

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:Pharmacological agents used in the treatment of anxiety have been reported to decrease threat relevant processing in patients and healthy controls, suggesting a potentially relevant mechanism of action. However, the effects of the anxiolytic diazepam have typically been examined at sedative doses, which do no...

journal_title：Psychopharmacology

authors： Murphy SE,Downham C,Cowen PJ,Harmer CJ

更新日期：2008-09-01 00:00:00

abstract：RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...

journal_title：Psychopharmacology

authors： Bowen DM,Procter AW,Mann DM,Snowden JS,Esiri MM,Neary D,Francis PT

更新日期：2008-03-01 00:00:00

abstract：:The effects of meperidine on operant behavioral thermoregulation were investigated using a convective thermal controller and mice trained to alternate at will the thermal-drive condition, changing it from an air flow of 15 degrees C to one of 45 degrees C, and vice versa. Administration of 15 mg/kg meperidine resulted...

journal_title：Psychopharmacology

authors： Gessner PK,Clarke CC

更新日期：1979-09-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Previous studies show that electrical stimulation of the ventral subiculum (vSub) can reinstate drug-seeking behavior in rats following extinction. This study examined whether vSub stimulation could also evoke reinitiation of d-amphetamine (d-AMPH) self-administration during voluntary abstinenc...

journal_title：Psychopharmacology

authors： Taepavarapruk P,Phillips AG

更新日期：2003-07-01 00:00:00

abstract：:The behavioral effects of the benzodiazepine (BZP)-receptor partial inverse agonists, beta-CCE and FG 7142, are reviewed and the claim that these compounds possess "anxiogenic" properties is examined. Results obtained from human studies and global observations in animals, as well as those from experiments on aggressio...

journal_title：Psychopharmacology

authors： Thiébot MH,Soubrié P,Sanger D

更新日期：1988-01-01 00:00:00

abstract：:To analyze the involvement of dopamine (DA) and serotonin (5-HT) release in the stimulus properties of methamphetamine, two amphetamine analogs that selectively release either brain DA (phentermine) or 5-HT (fenfluramine) were tested for their ability to substitute for methamphetamine in rats discriminating methamphet...

journal_title：Psychopharmacology

authors： Munzar P,Baumann MH,Shoaib M,Goldberg SR

更新日期：1999-01-01 00:00:00

abstract：RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...

journal_title：Psychopharmacology

authors： El Yacoubi M,Ledent C,Parmentier M,Costentin J,Vaugeois JM

更新日期：2000-02-01 00:00:00

abstract：:Intracerebroventricular injections of gamma-aminobutyric acid (GABA) and of the GABA-transaminase inhibitor, ethanolamine-O-sulphate (EOS), decreased the food intake of freely-fed (GABA and EOS) and food-deprived rats (EOS). The effect, still evident 24 h after treatment, was not decreased by the GABA receptor-blocker...

journal_title：Psychopharmacology

authors： Olgiati VR,Netti C,Guidobono F,Pecile A

更新日期：1980-01-01 00:00:00