Abstract:
:A placebo-controlled study with six normal volunteers was carried out using 1 mg haloperidol IM. In some EEG frequency bands, the power density due to haloperidol appeared to increase or decrease depending on the subject. Nevertheless, if the results of the six subjects are taken together, the effects of haloperidol are in agreement with the literature. No correlation was found between plasma concentration of haloperidol and EEG response. Some methodological problems are discussed.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wieneke GH,Verhoeven WM,Westenberg HG,de Wilde H,Lopes da Silva FH,van Praag M,Storm van Leeuwen Wdoi
10.1007/BF00431753subject
Has Abstractpub_date
1981-01-01 00:00:00pages
33-4issue
1eissn
0033-3158issn
1432-2072journal_volume
74pub_type
临床试验,杂志文章abstract::Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432549
更新日期:1982-01-01 00:00:00
abstract::This study examined whether the anticholinergic potency of the clinically superior antipsychotic drug clozapine contributes to clozapine's anatomically-selective functional inhibition of the mesolimbic dopamine (DA) system, using an electrical brain-stimulation reward (BSR) paradigm in rats that has been previously sh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246960
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4607-8
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES:This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cess...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-017-4580-2
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist. OBJECTIVES:The purpose of this work was to assess V1a receptor affinity and selectivity of JNJ-17308616 and in vivo efficacy in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1354-x
更新日期:2009-03-01 00:00:00
abstract::Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02180028
更新日期:1988-01-01 00:00:00
abstract::The uptake of 3H-5-HT in synaptosomes from rat brains was investigated. Addition of DA or NA had only a slight or no effect on the uptake. When the uptake into NA and DA neurons was inhibited by the addition of high concentrations of NA and DA, the uptake of 3H-5-HT was unchanged. This was also found after destruction...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429172
更新日期:1978-12-15 00:00:00
abstract::Postsynaptic dopamine-cholecystokinin (CCK) interactions in the nucleus accumbens were studied in two behavioral preparations of DA receptor supersensitivity: chronic-neuroleptic treated and 6-hydroxydopamine (6-OHDA) denervated rats. Subcutaneous (SC) injections of apomorphine (APO; 0.15 mg/kg) in experiment 1 produc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445568
更新日期:1989-01-01 00:00:00
abstract::The effects of vitamin B12 are compared to those of aspirin and 0.9% saline in three different experimental pain models in rats and mice; an electric shock test, the hot-plate test, and the phenylbenzoquinone writhing test. Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427267
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards. OBJECTIVES:Experiment 1 investigated whet...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1779-x
更新日期:2010-04-01 00:00:00
abstract:RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4008-9
更新日期:2015-11-01 00:00:00
abstract::The behavioral responses to separate and combined administration of the D1 agonist SKF-38393 and the D2 agonist quinpirole following acute dopamine (DA) depletion via alpha-methyl-p-tyrosine (AMPT) or AMPT/reserpine were examined in infant (10-day-old) and weanling (21-day-old) rat pups. At both ages, AMPT pretreatmen...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244963
更新日期:1992-01-01 00:00:00
abstract::Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429002
更新日期:1983-01-01 00:00:00
abstract::N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439104
更新日期:1977-04-29 00:00:00
abstract:RATIONALE:Previous observations revealed that defeated and subsequently individually housed rats do not display behavioral anticipatory responses to the conditioned presentation of a bell/light stimulus associated with free access to a 5% sucrose solution reward. The absence of the appetitive responses suggests a decre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1093-3
更新日期:2002-07-01 00:00:00
abstract:RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0992-8
更新日期:2008-03-01 00:00:00
abstract::The present studies were undertaken to investigate the neuroactive steroidal modulation of feeding behavior and possible involvement of gamma-aminobutyric acid type-A (GABA-A) and mitochondrial diazepam binding inhibitor (DBI) receptors (MDR) in food-deprived male mice. Allopregnanolone (0.5-2 mg/kg), a neurosteroid, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050635
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4579-8
更新日期:2017-05-01 00:00:00
abstract::Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426393
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-09-01 00:00:00
abstract:RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1814-x
更新日期:2004-09-01 00:00:00
abstract::The cognitive deficits, particularly memory impairment, observed in association with organic brain damage caused by chronic alcohol ingestion, are consistent with the profile of benzodiazepine-induced amnesia. This study examined the cognitive capabilities of a group of heavy social drinkers (n = 11) and a group of lo...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244897
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Glucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning. OBJECTIVES:The ai...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-010-2112-4
更新日期:2011-05-01 00:00:00
abstract:RATIONALE:Convergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between the amygdala and the prefrontal cortex (PFC), alcohol's effects are likely to extend beyond regional ch...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3090-0
更新日期:2013-09-01 00:00:00
abstract:RATIONALE:Fluoxetine (Prozac®) is the most frequently prescribed drug to battle depression in pregnant women, but its safety in the unborn child has not yet been established. Fluoxetine, a selective serotonin reuptake inhibitor, crosses the placenta, leading to increased extracellular serotonin levels and potentially n...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2299-z
更新日期:2011-10-01 00:00:00
abstract:RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1254-4
更新日期:2003-09-01 00:00:00
abstract:RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3716-x
更新日期:2015-03-01 00:00:00
abstract:RATIONALE:Acute physical dependence refers to the withdrawal syndrome precipitated by an opioid antagonist administered several hours after either a single dose or a short-term infusion of an opioid agonist. OBJECTIVES:We examined the mechanism of nicotine-induced attenuation of naloxone-precipitated withdrawal syndro...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1595-7
更新日期:2004-02-01 00:00:00
abstract:RATIONALE:Alzheimer's disease (AD) is characterized by memory loss and synaptic damage. Previous studies suggested that xanthoceraside decreases glutamate-induced PC12 cell death, ameliorates memory deficits, and increases the number of dendritic spines in AD mice. These results indicated that xanthoceraside might have...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4775-6
更新日期:2018-01-01 00:00:00
abstract:RATIONALE:In an animal model for vulnerability to drug abuse, rats that are more reactive to a novel environment (high responders, HRs) are more sensitive to behavioral effects of psychostimulants than are less reactive rats (low responders, LRs). In a companion article, we reported that HRs and LRs differ in sensitivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1921-8
更新日期:2004-12-01 00:00:00