Abstract：
:Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four reversals of that discrimination. No effect of fluphenazine administration was seen in the rate of learning the original discrimination, but the carryover of learning across discrimination reversals was significantly reduced by fluphenazine. After overtraining on the original discrimination, the controls showed the normal difficulty in learning the first reversal. The fluphenazine-treated monkeys showed no such disruption. On subsequent reversals, the controls showed continually improving performance, so that on the third and fourth reversals they had near-perfect scores. On the other hand, the fluphenazine-treated monkeys showed no change over the four reversals. Unlike normal monkeys, their learning did not improve with practice. Although simple forms of learning seem to be relatively unaffected by chronic fluphenazine administration, more complex learning is disrupted.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Levin ED,Gunne LMdoi
10.1007/BF00439554subject
Has Abstractpub_date
1989-01-01 00:00:00pages
496-500issue
4eissn
0033-3158issn
1432-2072journal_volume
97pub_type
杂志文章abstract：:A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427112
更新日期：1981-01-01 00:00:00
abstract：:The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control d...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428551
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000470
更新日期：2000-07-01 00:00:00
abstract：RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-006-0622-x
更新日期：2007-03-01 00:00:00
abstract：RATIONALE/OBJECTIVES:The impact of raising glycaemia by ingestion of a glucose drink has revealed cognitive facilitation, particularly for memory and attention. This study aimed to extend current knowledge by examining, for the first time, whether glucose load also moderates task-related (TRT) and task-unrelated though...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3926-x
更新日期：2015-08-01 00:00:00
abstract：RATIONALE:Temporal differentiation in the free-operant psychophysical procedure is sensitive to the 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT2 receptor agonist 2,5-dimethoxy-4-iodo-amphetamine (DOI); both drugs shift the psychophysical curve leftwards...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1871-1
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-2168-8
更新日期：2005-07-01 00:00:00
abstract：INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4657-y
更新日期：2017-08-01 00:00:00
abstract：RATIONALE:Numerous substituted cathinone drugs have appeared in recreational use. This variety is often a response to legal actions; the scheduling of 3,4-methylenedioxypyrovalerone (MDPV; "bath salts") in the USA was followed by the appearance of the closely related drug α-pyrrolidinopentiophenone (alpha-PVP; "flakka"...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3944-8
更新日期：2015-08-01 00:00:00
abstract：:Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02439600
更新日期：1987-01-01 00:00:00
abstract：:Cocaine and amphetamine produce several behavioral effects, most notably locomotor stimulation. Biochemically, evidence suggests specific involvement of dopaminergic systems, although not necessarily identical sites, in mediating cocaine- and amphetamine-induced locomotor stimulation. This study examined the effects o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245649
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Beneficial effects of nicotine on cognitive processes including attention have potential therapeutic uses and have been proposed as incentives for tobacco smoking. OBJECTIVES:To establish task conditions under which the effects of nicotine on attention are obtained reliably and to characterise such effects f...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1005-6
更新日期：2002-07-01 00:00:00
abstract：RATIONALE:The cerebral microdialysis technique has been widely used to monitor the release of 5-hydroxytryptamine (5-HT). The extracellular concentration of 5-HT has generally been shown to change after pharmacological manipulation as expected. Extracellular levels of the metabolite, 5-hydroxyindoleaceticacid (5-HIAA) ...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-003-1736-z
更新日期：2004-03-01 00:00:00
abstract：RATIONALE:Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are components of the mechanism that mediates the overall effects of nic...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2895-6
更新日期：2013-03-01 00:00:00
abstract：RATIONALE:Prospective memory pervades our daily lives and failures can have detrimental consequences. This ability to execute delayed intentions may be impacted by stress, yet few studies have examined these effects. Moreover, as many cannabis users report using cannabis to cope with stress, it is important to understa...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-5184-9
更新日期：2019-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00690931
更新日期：1987-01-01 00:00:00
abstract：:Haloperidol disposition has been associated with reversible metabolism: it is reversibly reduced to its metabolite, reduced haloperidol, which has less pharmacologic activity than the parent compound. To characterize the interconversion process, six healthy male schizophrenics were administered a single dose of 10 mg ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02253726
更新日期：1990-01-01 00:00:00
abstract：:Acute alcohol intoxication disrupts memory acquisition in humans and laboratory animals. This review summarizes recent behavioral and immediate early gene expression studies addressing the mechanisms of this phenomenon. Most behavioral investigations agree that the amnestic effect of alcohol is due to its preferential...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s002130050687
更新日期：1998-09-01 00:00:00
abstract：RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100891
更新日期：2001-12-01 00:00:00
abstract：RATIONALE:Electrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about t...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2426-x
更新日期：2012-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2902-y
更新日期：2013-03-01 00:00:00
abstract：:Forskolin, a diterpene isolated from the plant Coleus forskolii, activates the catalytic subunit of adenylate cyclase, resulting in a hormone receptor-independent increase in the intracellular production of cyclic AMP. This study was undertaken to assess the effect of chronic in vivo infusion of forskolin on noradrene...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432514
更新日期：1985-01-01 00:00:00
abstract：RATIONALE:Gabolysat PC60 is a fish protein hydrolysate with anxiolytic properties commonly used as a nutritional supplement. OBJECTIVE:The diazepam-like effects of PC60 on stress responsiveness of the rat pituitary-adrenal system and on sympathoadrenal activity were studied. METHODS:The activity of the pituitary-adre...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002139900338
更新日期：2000-03-01 00:00:00
abstract：:Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050730
更新日期：1998-10-01 00:00:00
abstract：:The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432040
更新日期：1984-01-01 00:00:00
abstract：:Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03-1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00589905
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals. OBJECTIVE:The effects of salvinorin A on the zebrafish (Danio rerio) model, through its swimming behavior and conditioned place preference (CPP) task, was studied. MATE...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0639-1
更新日期：2007-03-01 00:00:00
abstract：RATIONALE:Endogenous γ-aminobutyric acidA receptor (GABAAR)-active neurosteroids (e.g., allopregnanolone) regulate central nervous system excitability and many physiological functions, so fluctuations are implicated in several neuropsychiatric disorders. Pertinently, evidence supports an inverse relationship between en...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4671-0
更新日期：2017-09-01 00:00:00
abstract：RATIONALE:Repeated high doses of morphine in the rat cause stereotypic gnawing behavior that can be re-expressed by a low dose of morphine weeks and even months after the initial treatment. The determination of the role of serotonin in this sensitized morphine-induced behavior has both empirical and theoretical relevan...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051083
更新日期：1999-09-01 00:00:00
abstract：RATIONALE:The effects of acute bouts of physical activity (PA) on Strength of Desire (SoD) and Desire to Smoke (DtS) using individual participant data (IPD) from 19 acute randomised controlled studies were quantified. However, there is a need to identify factors influencing this relationship. OBJECTIVES:To understand ...
journal_title：Psychopharmacology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00213-014-3450-4
更新日期：2014-04-01 00:00:00
