Abstract:
RATIONALE:Animal models of alcohol-seeking are useful for understanding alcohol addiction and for treatment development, but throughput in these models is limited by the extensive pretraining required to overcome the aversive taste of ethanol. Work by Augier et al. (Psychopharmacology 231: 4561-4568, 2014) indicates that Wistar rats will self-administer alcohol without water deprivation, exposure to sweetened ethanol solutions or intermittent access to ethanol. OBJECTIVES AND METHODS:We sought to replicate and extend the work of Augier et al. by comparing the acquisition of instrumental self-administration of ethanol in Lister-Hooded rats that had been previously saccharin faded (SF group) or not (NSF group). We also aimed to determine whether NMDA receptor antagonism with MK-801, given at memory reactivation, reduced subsequent ethanol-seeking behaviour in both groups of animals. Finally, we assessed the ethanol preference of SF and NSF rats using the two-bottle choice procedure. RESULTS:Both SF and NSF groups acquired instrumental self-administration of ethanol, though SF rats consumed fewer of the earned reinforcers. MK-801, given at memory reactivation, had different effects on NSF and SF rats: impairing the capacity of an ethanol-paired conditioned stimulus (CS) to support reinstatement in NSF rats, and enhancing it in SF rats. Finally, neither SF nor NSF rats showed a preference for ethanol. CONCLUSIONS:Our data support those of Augier et al. (Psychopharmacology 231: 4561-4568, 2014) that pretraining is unnecessary for rats to acquire instrumental self-administration of ethanol. Indeed, saccharin fading may produce a weaker memory that extinguishes more readily, thus accounting for the different effects of MK-801 on SF and NSF rats.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Puaud M,Ossowska Z,Barnard J,Milton ALdoi
10.1007/s00213-017-4824-1subject
Has Abstractpub_date
2018-04-01 00:00:00pages
1069-1082issue
4eissn
0033-3158issn
1432-2072pii
10.1007/s00213-017-4824-1journal_volume
235pub_type
杂志文章abstract:RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...
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doi:10.1007/s00213-005-0256-4
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doi:10.1007/BF02246140
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更新日期:2001-01-01 00:00:00
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更新日期:2007-04-01 00:00:00
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更新日期:2002-11-01 00:00:00
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更新日期:1992-01-01 00:00:00
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更新日期:2015-09-01 00:00:00