Role of the strychnine-insensitive glycine binding site in the nucleus accumbens and anterodorsal striatum in sensorimotor gating: a behavioral and microdialysis study.

abstract：:The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in ...

journal_title：Psychopharmacology

authors： Dworkin SI,Gleeson S,Meloni D,Koves TR,Martin TJ

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Stress is associated with cognitive and emotional dysfunction, and increases risk for a variety of psychological disorders, including depression and posttraumatic stress disorder. Prefrontal cortex is critical for executive function and emotion regulation, is a target for stress hormones, and is implicated i...

journal_title：Psychopharmacology

authors： Wellman CL,Moench KM

更新日期：2019-01-01 00:00:00

abstract：:During the third week of life, a hyperactive period for laboratory rat, the occurrence of 8 behavioral categories was recorded in individual littermates transferred to a novel environment. Neonatal destruction of the catecholaminergic system by intraventricular injection of 6-OH-DA resulted in increased motor activity...

journal_title：Psychopharmacology

authors： Stoof JC,Duijkstra H,Hillegers JP

更新日期：1978-04-28 00:00:00

abstract：RATIONALE:Although environmental enrichment renders rats more sensitive to the neurobehavioral effects of acute amphetamine, a previous study found that enriched rats self-administer less amphetamine than isolated rats at a low unit dose (0.03 mg/kg per infusion). In that study, however, acquisition of self-administrat...

journal_title：Psychopharmacology

authors： Green TA,Gehrke BJ,Bardo MT

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophre...

journal_title：Psychopharmacology

authors： Pouget P,Wattiez N,Rivaud-Péchoux S,Gaymard B

更新日期：2010-05-01 00:00:00

abstract：RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...

journal_title：Psychopharmacology

authors： Braden BB,Garcia AN,Mennenga SE,Prokai L,Villa SR,Acosta JI,Lefort N,Simard AR,Bimonte-Nelson HA

更新日期：2011-11-01 00:00:00

abstract：:The effects of the enantiomers of 3-PPP on the maintenance of conditioned avoidance responding (CAR) were studied. The weak classical dopamine (DA) agonist (+)-3-PPP failed to interfere with CAR at any dose tested (0.8-13.6 mg/kg). Low doses of the drug produced sedation, while high doses produced behavioural stimulat...

journal_title：Psychopharmacology

authors： Clark D,Carlsson A,Hjorth S,Engel J,Lindberg P

更新日期：1983-01-01 00:00:00

abstract：:The purpose of this study was to determine if multiple aspects of drug and food-reinforced behavior could be measured in a single study. Drug or food seeking can be observed under four conditions: 1) internal drug or food cues and external stimulus cues present; self-administration, 2) only internal cues present; prim...

journal_title：Psychopharmacology

authors： Foltin RW,Evans SM

更新日期：1997-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Previous studies have demonstrated that sensitization to repeated doses of cocaine results in prolonged changes in glutamate transmission. However, little is known about long-term changes in glutamate transmission following a single dose of cocaine. Our laboratory has previously reported that a...

journal_title：Psychopharmacology

authors： Kozell B,Meshul K

更新日期：2003-02-01 00:00:00

abstract：:Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...

journal_title：Psychopharmacology

authors： Krafft K,Cleary J,Poling A

更新日期：1983-01-01 00:00:00

abstract：:The development of a differential tolerance to morphine was investigated with respect to the mean effective dose, the threshold dose of tolerance, the degree of tolerance after a fixed dose, and the speed of tolerance loss. The mean effective doses, the threshold doses of tolerance, and the degree of tolerance differe...

journal_title：Psychopharmacology

authors： Fernandes M,Kluwe S,Coper H

更新日期：1982-01-01 00:00:00

abstract：:SCH 39166 is the first selective D1-dopamine receptor antagonist developed for clinical trials in schizophrenia. SCH 39166 was evaluated as a radioligand for PET, labeled with 11C, and as a D1-dopamine receptor antagonist after single oral doses in healthy men. After intravenous injection of [11C]SCH 39166 distributio...

journal_title：Psychopharmacology

authors： Karlsson P,Sedvall G,Halldin C,Swahn CG,Farde L

更新日期：1995-10-01 00:00:00

abstract：:Latent inhibition (LI) is a phenomenon in which repeated, non-reinforced presentation of a stimulus retards subsequent conditioning to that stimulus. Several recent experiments have suggested that LI is abolished following acute, low doses of amphetamine given during pre-exposure and conditioning, and this effect has ...

journal_title：Psychopharmacology

authors： Killcross AS,Robbins TW

更新日期：1993-01-01 00:00:00

abstract：:Animal and human studies have demonstrated that, depending upon the sequence of alcohol presentation, long-term memory of events can either be enhanced or diminished. In the present study a similar phenomenon is demonstrated in the neuronal excitability of slices of hippocampus from guinea pig brains. Alcohol given af...

journal_title：Psychopharmacology

authors： Oliver AP,Parker ES,Wyatt RJ

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Recent animal research has shown that, aside from its primary and secondary reinforcing effects, nicotine may enhance reinforcement from stimuli unrelated to nicotine intake. Little human research has directly examined this potentially important influence of nicotine. OBJECTIVES:We report two virtually ident...

journal_title：Psychopharmacology

authors： Perkins KA,Grottenthaler A,Wilson AS

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Alcohol drinking may lead to increased aggression in certain individuals, and both fighting and drinking increase levels of dopamine and serotonin in mesocorticolimbic structures. Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging. OB...

journal_title：Psychopharmacology

authors： van Erp AM,Miczek KA

更新日期：2007-04-01 00:00:00

abstract：RATIONAL:In recent years, evidence suggests that modafinil may be useful for certain symptom domains of schizophrenia, especially for the negative and cognitive symptoms. However, the results are not consistent. OBJECTIVE:This study was designed to investigate the effect of modafinil added to risperidone in patients w...

journal_title：Psychopharmacology

authors： Arbabi M,Bagheri M,Rezaei F,Ahmadi-Abhari SA,Tabrizi M,Khalighi-Sigaroudi F,Akhondzadeh S

更新日期：2012-04-01 00:00:00

abstract：:The effect of long-term lithium carbonate treatment on parameters of immediate, short-, and long-term memory was examined in a group of bipolar affectively ill patients. The lithium treatment group recalled significantly fewer words across trials on a verbal learning task than a group of bipolar affectively ill patien...

journal_title：Psychopharmacology

authors： Reus VI,Targum SD,Weingartner H,Post RM

更新日期：1979-05-08 00:00:00

abstract：RATIONALE:Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibitio...

journal_title：Psychopharmacology

authors： Su B,Li S,Yang L,Zheng M

更新日期：2020-04-01 00:00:00

abstract：:The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...

journal_title：Psychopharmacology

authors： Turski L,Turski W,Czuczwar SJ,Kleinrok Z

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:There is an emerging body of evidence that implicates a crucial role of γ-aminobutyric acid subtype A (GABAA) receptors in modulating the rewarding effects of a number of abused drugs. Modulation of GABAA receptors may therefore represent a novel drug-class independent mechanism for the development of abuse t...

journal_title：Psychopharmacology

authors： Tracy ME,Banks ML,Shelton KL

更新日期：2016-02-01 00:00:00

abstract：RATIONALE:The effects of caffeine, especially caffeinated coffee, on human performance have been extensively studied. However, few studies have been naturalistic representations of how tea/coffee is normally consumed in terms of dose and time of consumption. OBJECTIVES:This study investigated the effects of day-long c...

journal_title：Psychopharmacology

authors： Hindmarch I,Rigney U,Stanley N,Quinlan P,Rycroft J,Lane J

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. OBJECTIVES:Here, we decided to investigate the possible role of the group III mGlu receptor ligands, LSP1-2111, the g...

journal_title：Psychopharmacology

authors： Wierońska JM,Stachowicz K,Acher F,Lech T,Pilc A

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:The influence of the main dopaminergic brain regions controlling copulation, the medial preoptic area (mPOA) and the nucleus accumbens (NAcc), on male rat sexual behavior expression has not been fully established. OBJECTIVE:This work analyzes the sexual effects of dopamine (DA) receptor activation in the mPO...

journal_title：Psychopharmacology

authors： Guadarrama-Bazante IL,Rodríguez-Manzo G

更新日期：2019-04-01 00:00:00

abstract：:Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...

journal_title：Psychopharmacology

authors： Biegon A,Greuner N

更新日期：1992-01-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning procedures in female rats. METHODS:Animals received nicotine in their initially non-preferred side and saline on alternate days in their initially preferr...

journal_title：Psychopharmacology

authors： Torres OV,Natividad LA,Tejeda HA,Van Weelden SA,O'Dell LE

更新日期：2009-10-01 00:00:00

abstract：RATIONALE:A previously reported pharmacokinetic interaction between bromperidol and carbamazepine, an inducer of cytochrome P450 (CYP) 3A4, suggests possible involvement of CYP3A4 in the metabolism of bromperidol. OBJECTIVE:We investigated pharmacokinetic interaction between bromperidol and itraconazole, a potent inhi...

journal_title：Psychopharmacology

authors： Furukori H,Kondo T,Yasui N,Otani K,Tokinaga N,Nagashima U,Kaneko S,Inoue Y

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Little is known about the smoking topography characteristics of heavy cannabis users. Such measures may be able to predict cannabis use-related outcomes and could be used to validate self-reported measures of cannabis use. OBJECTIVES:The current study was conducted to measure cannabis smoking topography char...

journal_title：Psychopharmacology

authors： McClure EA,Stitzer ML,Vandrey R

更新日期：2012-03-01 00:00:00

abstract：RATIONALE:The ability of nicotine to induce dependence (result in a withdrawal syndrome) is typically thought to require long-term, daily smoking. Emerging evidence suggests that symptoms of nicotine withdrawal may occur following only a few cigarettes. Whether acute exposure to nicotine can induce dependence in animal...

journal_title：Psychopharmacology

authors： Harris AC,Manbeck KE,Schmidt CE,Shelley D

更新日期：2013-01-01 00:00:00

abstract：:Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...

journal_title：Psychopharmacology

authors： Piccirillo M,Alpert JE,Cohen DJ,Shaywitz BA

更新日期：1980-01-01 00:00:00