Abstract:
INTRODUCTION:The comparative effects of a newly described specific alpha7 nAChR partial agonist, S 24795, and a cholinesterase inhibitor, donepezil, currently used as a symptomatic Alzheimer's disease treatment were studied in two mouse models of aging-related memory deficits. MATERIALS AND METHODS:We employed radial arm-maze paradigms assessing short-term working memory (STWM, experiment A) and mnemonic flexibility, a cardinal property of long-term declarative (LTDM, experiment B). Both compounds were administered daily at 0.3 and 1 mg/kg subcutaneously (~3 weeks). RESULTS:In the STWM experiment, vehicle-treated aged mice displayed a severe and persistent deficit in the retention of successive arm visits in comparison to younger controls. S 24795 at 1 mg/kg (trends at 0.3 mg/kg) and donepezil at 0.3 mg/kg (but not 1 mg/kg) exerted beneficial effects on this deficit: The performance of aged mice treated with these drugs remarkably increased across the testing days and almost reached young adult performance level. In the critical test trials of memory flexibility (i.e., LTDM), in experiment B, S 24795 at 1 mg/kg (trends at 0.3 mg/kg) and donepezil at the dose of 1 mg/kg (but not 0.3 mg/kg) improved aged mice performance. CONCLUSION:This preclinical demonstration that S 24795 restored specific age-related memory deficits with as much efficacy as donepezil adds to recent literature in highlighting the potential interest of an alpha7 nAChR drug as a symptomatic AD therapeutic.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Marighetto A,Valerio S,Desmedt A,Philippin JN,Trocmé-Thibierge C,Morain Pdoi
10.1007/s00213-007-1063-xsubject
Has Abstractpub_date
2008-04-01 00:00:00pages
499-508issue
3eissn
0033-3158issn
1432-2072journal_volume
197pub_type
杂志文章abstract:RATIONALE:Cortisol hypersecretion is regarded as important in the pathophysiology of major depression. However, recent studies in community-based samples have been inconclusive. OBJECTIVE:To determine whether acutely depressed, medication-free subjects show an exaggerated release of cortisol in saliva in relation to a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0062-z
更新日期:2005-10-01 00:00:00
abstract::The noradrenergic system has repeatedly been implicated in the mediation of attentional processes. Using a double-blind, placebo-controlled design, the present investigation examines the effects of two doses (1.5 micrograms/kg and 2.5 micrograms/kg) of the alpha 2 adrenoceptor agonist clonidine (CLO) on performance of...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02311180
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abstract::The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml i.v.) or received yok...
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pub_type: 杂志文章
doi:10.1007/s002130050496
更新日期:1998-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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abstract:RATIONALE:Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES:Here, we sought to investigate sex differences in dopamine release after oral D-amphetamine ad...
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doi:10.1007/s00213-011-2619-3
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244252
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2005-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050275
更新日期:1997-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1978-12-08 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-002-1187-y
更新日期:2002-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310620
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pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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更新日期:2020-12-21 00:00:00
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更新日期:2006-01-01 00:00:00
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更新日期:2003-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1987-01-01 00:00:00
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更新日期:2004-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-01-01 00:00:00