Abstract:
:Changes in smooth pursuit eye tracking of targets moving sinusoidally in horizontal and vertical planes before and after up to 10 mg oral methadone were measured electrooculographically in nontolerant nondependent humans. Methadone depressed the gain of horizontal tracking movements at most frequencies tested (0.2 - 1.6 Hz) without changing target-eye phase relationships. Lack of change in target-eye cross-correlation functions after methadone and examination of individual records indicate that gain reduction was due to the eye failing to follow the target to the full extent of target excusion (+5 degrees from eyes straight ahead view). Possible mechanisms and the practical consequences of methadone action on smooth pursuit were discussed.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Rothenberg S,Schottenfeld S,Selkoe D,Gross Kdoi
10.1007/BF00431261subject
Has Abstractpub_date
1980-01-01 00:00:00pages
229-34issue
3eissn
0033-3158issn
1432-2072journal_volume
67pub_type
临床试验,杂志文章,随机对照试验abstract::When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427646
更新日期:1980-01-01 00:00:00
abstract::The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212851
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2032-3
更新日期:2011-02-01 00:00:00
abstract::The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putativ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050757
更新日期:1998-11-01 00:00:00
abstract::EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244335
更新日期:1993-01-01 00:00:00
abstract::Postsynaptic dopamine-cholecystokinin (CCK) interactions in the nucleus accumbens were studied in two behavioral preparations of DA receptor supersensitivity: chronic-neuroleptic treated and 6-hydroxydopamine (6-OHDA) denervated rats. Subcutaneous (SC) injections of apomorphine (APO; 0.15 mg/kg) in experiment 1 produc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445568
更新日期:1989-01-01 00:00:00
abstract::The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00426651
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05462-7
更新日期:2020-05-01 00:00:00
abstract:RATIONALE:The search for novel antipsychotic drugs to treat schizophrenia is driven by the poor treatment efficacy, serious side effects, and poor patient compliance of current medications. Recently, a class of compounds known as tetrahydroprotoberberines, which includes the compound d,l-govadine, have shown promise in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4540-x
更新日期:2017-04-01 00:00:00
abstract:RATIONALE:Cortisol hypersecretion is regarded as important in the pathophysiology of major depression. However, recent studies in community-based samples have been inconclusive. OBJECTIVE:To determine whether acutely depressed, medication-free subjects show an exaggerated release of cortisol in saliva in relation to a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0062-z
更新日期:2005-10-01 00:00:00
abstract:INTRODUCTION:Nearly 25% of American adults remain regular smokers. Current smokers may be especially likely to possess characteristics that impair their ability to quit, such as impulsivity. Impulsive individuals may be overly prone to smoke because they are particularly drawn to rewarding stimuli and related cues. The...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0832-x
更新日期:2007-10-01 00:00:00
abstract:RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5068-4
更新日期:2019-01-01 00:00:00
abstract::Effects of the dopamine D2 receptor antagonist sulpiride and the D1 antagonist SCH-23390 were examined, in rats, in two-bottle preference tests (sucrose versus water) and in single-bottle tests, at different sucrose concentrations. Both drugs decreased sucrose intake in single bottle tests, at low sucrose concentratio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00634461
更新日期:1989-01-01 00:00:00
abstract::The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal half-life (mean +/- SE, n = 8) of 8.3 +/- 0.3 min due to a large total blood clearance of 1...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244294
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the prefrontal cortex (PFC) at doses that had similar effects in the nucleus accumbens. Since working memory depends on PFC DA, it was postulated that AMPH w...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1522-y
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:The thalamus is a major target of dopaminergic projections and is densely connected with the prefrontal cortex. A better understanding of how dopamine changes thalamo-cortical communication may shed light on how dopamine supports cognitive function. Methylphenidate has been shown to facilitate cognitive proc...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-020-05505-z
更新日期:2020-06-01 00:00:00
abstract::The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050683
更新日期:1998-08-01 00:00:00
abstract:AIM:The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF). METHOD:Following 2-4 h of nicotine abstinence, healthy chronic smokers participated in four sets of rCBF studies, H2(15)O positron emission tomography, during a simple sensory motor control...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1758-2
更新日期:2010-03-01 00:00:00
abstract::The pharmacokinetic and pharmacodynamic effects of concomitant administration of alprazolam and fluoxetine were studied in this double-blind parallel study in 80 healthy, male volunteers. Subjects were randomly assigned to one of four treatment groups. Drug treatments consisted of 4-day regimens of 1 mg alprazolam fou...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246031
更新日期:1991-01-01 00:00:00
abstract::A simple new method, the "tape test" has been developed for studying the enhancement of learning by drugs in "learning-dull" rats. A piece of adhesive tape is pressed on the left front pad of the rats. The time of tape removal by the animal, i.e., the problem-solving time is measured. In our experiments the selected l...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00423313
更新日期:1976-07-09 00:00:00
abstract:OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-017-4622-9
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. OBJECTIVES:The present experiments evaluated the influence of opioid re...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051101
更新日期:1999-09-01 00:00:00
abstract::Adult female offspring of C57BL/6J mice injected daily with phenobarbital for the last third of pregnancy were more active than control offspring during a 3-min test period in an open field arena, thus confirming previous reports of lasting effects of prenatal exposure to phenobarbital. These offspring habituated less...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432745
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Impulsive behaviour is a component of psychiatric disorders such as bipolar disorder, attention deficit hyperactivity disorder (ADHD), or personality disorders. Most experimental studies on impulsive behaviour punish impulsive choices by loss or delay of reward. In the present study, impulsive behaviour was p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2163-0
更新日期:2005-07-01 00:00:00
abstract::The aim of the present study was to (i) characterise the mouse behavioural profile (particularly social interactions) during the preweaning period, (ii) assess the effects of prenatal exposure to an anticonvulsant drug widely used in clinical practice, (iii) examine possible genetic differences both in baseline behavi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245214
更新日期:1994-01-01 00:00:00
abstract:RATIONALE:Batteries of tests that are thought to measure different aspects of anxiety-related behaviour are used to characterise mice after genetic or pharmacological manipulation. However, because of the potentially confounding effects of repeated testing and natural intra-individual variations in behaviour over time,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1873-0
更新日期:2010-07-01 00:00:00
abstract:RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05463-6
更新日期:2020-05-01 00:00:00
abstract::Depression in children is currently an area of considerable controversy, as is the use of potent psychopharmacologic agents in children. Since EEG sleep techniques have proven to be useful in understanding the mechanisms of depression in adults and in predicting their response to antidepressants, a pilot study employi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432281
更新日期:1979-01-31 00:00:00
abstract:RATIONALE:The cerebral microdialysis technique has been widely used to monitor the release of 5-hydroxytryptamine (5-HT). The extracellular concentration of 5-HT has generally been shown to change after pharmacological manipulation as expected. Extracellular levels of the metabolite, 5-hydroxyindoleaceticacid (5-HIAA) ...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-003-1736-z
更新日期:2004-03-01 00:00:00
abstract::Four-day-old chicks respond to isolation with distress calling. A decrease in distress calling during isolation seems to reflect some general aspect of depressive syndrome and appears to be sensitive to pharmacological manipulation. Diverse clinically active antidepressants are able to counteract this decrease with hi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442235
更新日期:1989-01-01 00:00:00