Abstract：
:The aim of the present study was to (i) characterise the mouse behavioural profile (particularly social interactions) during the preweaning period, (ii) assess the effects of prenatal exposure to an anticonvulsant drug widely used in clinical practice, (iii) examine possible genetic differences both in baseline behavioural profiles and in sensitivity to drug-induced effects. Following a balanced intra-strain fostering procedure, the offspring of C57BL/6J and CBA inbred mouse strains from mothers exposed during pregnancy to either phenobarbitone (PHB, 60 mg/kg) or vehicle (VEH) given intraperitoneally (IP) during days 10-16 of gestation, were observed for early social interactions in the home cage during the last part of the preweaning period (days 20 and 21). The behavioural repertoires of the two strains differed markedly, in that C57 pups were more involved in Play soliciting, Locomotor-rotational play, and in Maintenance activities, while CBA mice spent much more time being inactive or exploring the environment. C57 and CBA mice also differed in the sensitivity to PHB exposure. On the whole, time spent in Investigative/Affiliative behaviours was increased, while the frequency of Play soliciting patterns was reduced in PHB-treated mice. The treatment of the fostering mother had only negligible effects, suggesting that PHB-induced changes in behaviour were largely due to direct effects of the substance on the foetus. These results indicate that specific items of the preweaning behavioural profile, and particularly social interactions, are influenced by early PHB exposure, and that the responses are heavily affected by the genotype.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Laviola G,Terranova ML,Sedowofia K,Clayton R,Manning Adoi
10.1007/BF02245214subject
Has Abstractpub_date
1994-01-01 00:00:00pages
388-94issue
3-4eissn
0033-3158issn
1432-2072journal_volume
113pub_type
杂志文章abstract：:The effects of intra-amygdala injections of corticotropin-releasing factor (CRF) on memory and exploratory behavior in rats were examined in the present study. Rats with chronically implanted cannulae received intra-amygdala injections of vehicle or CRF at a dose of 0.01, 0.1 or 1.0 micrograms, either immediately afte...
journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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更新日期：1976-11-24 00:00:00
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更新日期：2017-05-01 00:00:00
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doi：10.1007/BF02246668
更新日期：1996-04-01 00:00:00
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更新日期：1996-10-01 00:00:00
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更新日期：1996-04-01 00:00:00
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更新日期：1995-05-01 00:00:00
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更新日期：1996-08-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2010-04-01 00:00:00
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更新日期：2010-05-01 00:00:00
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更新日期：1999-08-01 00:00:00
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更新日期：1993-01-01 00:00:00
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更新日期：2017-04-01 00:00:00
