Abstract:
:The urinary excretion of 4-hydroxy-3-methoxyphenylglycol was compared in a group of 23 depressive patients and 27 control subjects of similar age. There was no difference between patients and controls although female controls excreted less than males. After 6 weeks' treatment with 150 mg daily of amitriptyline there was no correlation between therapeutic response and pretreatment urinary excretion value.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Coppen A,Rama Rao VA,Ruthven CR,Goodwin BL,Sandler Mdoi
10.1007/BF00427352subject
Has Abstractpub_date
1979-06-28 00:00:00pages
95-7issue
1eissn
0033-3158issn
1432-2072journal_volume
64pub_type
杂志文章abstract:RATIONALE:Stimulation of central beta(2) adrenergic receptors produces antidepressant-like effects on behavior. At present, it is not known what brain sites are involved in mediating such effects, although some recent evidence suggests the importance of the dorsal hippocampus. OBJECTIVE:Experiments were carried out to...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1512-0
更新日期:2003-10-01 00:00:00
abstract:RATIONALE:Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilita...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-015-3882-5
更新日期:2015-07-01 00:00:00
abstract::To analyze the involvement of dopamine (DA) and serotonin (5-HT) release in the stimulus properties of methamphetamine, two amphetamine analogs that selectively release either brain DA (phentermine) or 5-HT (fenfluramine) were tested for their ability to substitute for methamphetamine in rats discriminating methamphet...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050836
更新日期:1999-01-01 00:00:00
abstract:RATIONALE:Although most opioid self-administration research has been conducted with laboratory animals, such research with humans is necessary to answer questions unique to human drug-taking behavior. OBJECTIVE:We investigated the influence of morphine dose and an alternative non-drug reinforcer on choice between morp...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050051
更新日期:2000-02-01 00:00:00
abstract::It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00735892
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1583-y
更新日期:2004-01-01 00:00:00
abstract:RATIONALE:Trichotillomania is characterized by repetitive pulling causing noticeable hair loss. Pharmacological treatment data for trichotillomania are limited. OBJECTIVE:Dronabinol appears to reduce the exocitotoxic damage caused by glutamate release in the striatum and offers promise in reducing compulsive behavior....
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-011-2347-8
更新日期:2011-12-01 00:00:00
abstract:RATIONALE:Prior research suggests that high levels of acetylcholine (ACh) in the nucleus accumbens (NAc) are associated with aversive states such as morphine withdrawal, but this has not been tested for nicotine withdrawal. OBJECTIVES:The goal was to test the hypothesis that acute nicotine decreases extracellular ACh ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100781
更新日期:2001-08-01 00:00:00
abstract::There were marked strain differences in the duration of the protective effects of diazepam against the convulsant actions of penylenetetrazole and picrotoxin in mice. In no case was significant protection found at 12 h or longer, regardless of whether the incidence of or the latencies to myoclonus or tonic-clonic conv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431698
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2278-4
更新日期:2011-09-01 00:00:00
abstract:RATIONALE:Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4239-4
更新日期:2016-04-01 00:00:00
abstract::NCQ 298 ((S)-3-iodo-N-[(l-ethyl-2-pyrrolidinyl)methyl]-5,6- dimethoxysalicylamide) has an iodine substituent. We have labelled NCQ 298 with 123I and 125I, and used the radioligands as tracers in receptor studies in vitro, in vivo in autoradiography and in SPECT studies on Cynomolgus monkeys. [125I]NCQ 298 bound in vit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244067
更新日期:1991-01-01 00:00:00
abstract::Administration to mice of harmaline (100 mg/kg SC) resulted in a greater than two-fold increase in cyclic GMP in the cerebellum 15 min later. This response was inhibited by pretreatment 5 min before the harmaline with pentobarbital (ED50 6.5 mg/kg), chlormethiazole (ED50 10.4 mg/kg) and dizocilpine (ED50 0.5 mg/kg). H...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02257413
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-009-1591-7
更新日期:2009-11-01 00:00:00
abstract:RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0081-9
更新日期:2005-10-01 00:00:00
abstract::The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement wa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179198
更新日期:1986-01-01 00:00:00
abstract::Animal and human studies have demonstrated that, depending upon the sequence of alcohol presentation, long-term memory of events can either be enhanced or diminished. In the present study a similar phenomenon is demonstrated in the neuronal excitability of slices of hippocampus from guinea pig brains. Alcohol given af...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426380
更新日期:1984-01-01 00:00:00
abstract::Rats treated weekly with cumulative doses (1-100 mg/kg, IP) of naltrexone develop an enhanced sensitivity to the operant response-rate decreasing effect of naltrexone. In the present experiment the pharmacological specificity of that enhanced sensitivity was determined by testing a variety of drugs for cross-sensitivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246951
更新日期:1993-01-01 00:00:00
abstract::Single oral and intramuscular (i.m.) doses of imipramine (IMI) were administered to four normal males. Serum and urine concentrations of IMI, desipramine (DMI) and their unconjugated 2-hydroxy metabolites were measured by high-pressure liquid chromatography (HPLC). Urinary conjugated 2-hydroxy metabolites were also me...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427676
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:It has recently been reported that chronic nicotine administration at subconvulsive doses causes seizures, a phenomenon referred to as kindling. Evidence points to the involvement of oxidative stress in pharmacological and electrical kindling, sex is known to influence the brain's response to nicotine. OBJEC...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2799-5
更新日期:2013-01-01 00:00:00
abstract::In two experiments, phenobarbitone sodium (30 mg/kg) reliably enhanced water consumption and extended the duration of drinking in 24h water-deprived male rats. The opiate receptor antagonists naloxone (0.1-10 mg/kg) and naltrexone (0.1-10 mg/kg) both decreased water intake and reduced the duration of drinking. When th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433011
更新日期:1983-01-01 00:00:00
abstract::Few studies have examined the association between ethanol use and cigarette smoking topography. In particular, no study has objectively investigated the relationship between chronic ethanol exposure and cigarette smoking. The aim of this study was to quantify the relationship between cigarette smoking and past and cur...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245794
更新日期:1990-01-01 00:00:00
abstract::A study was performed to examine behavioral response to a challenge of selective dopamine D-1 and D-2 agonists in rats previously sensitized by subchronic administration of methamphetamine or cocaine. Rats in three groups received repeated injections (IP) of saline, methamphetamine (4 mg/kg/day) or cocaine (20 mg/kg/d...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247125
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:In an animal model for vulnerability to drug abuse, rats that are more reactive to a novel environment (high responders, HRs) are more sensitive to behavioral effects of psychostimulants than are less reactive rats (low responders, LRs). In a companion article, we reported that HRs and LRs differ in sensitivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1921-8
更新日期:2004-12-01 00:00:00
abstract::Chronic administration of the pre-synaptic alpha-adrenoreceptor agonist clonidine decreases the concentration of the extra-neuronal metabolite of noradrenaline normetanephrine in the amygdaloid cortex and increases it in the mid-brain. Conversely, blockade of these pre-synaptic receptors by yohimbine increases the nor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427519
更新日期:1979-09-01 00:00:00
abstract::The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within ea...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244216
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:One third of US smokers are intermittent smokers (ITS) who do not smoke daily. Unlike daily smokers (DS), whose smoking is negatively reinforced by withdrawal relief, ITS may be motivated by immediate positive reinforcement. In contrast, incentive salience theory posits hypothesis that "liking" of drug effect...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4682-x
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differenti...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-019-05246-8
更新日期:2019-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Dopamine (DA) agonists reliably disrupt prepulse inhibition (PPI) of the startle reflex in animals but less so in humans despite cross-species similarities in the neural regulation of PPI. This study examines whether individual variation in baseline PPI may account for the inconsistencies in DA...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0056-x
更新日期:2005-10-01 00:00:00
abstract::Both muscarinic antagonists, such as scopolamine, and benzodiazepine receptor (BZR) agonists, such as diazepam, produce a reliable impairment in the performance of one trial passive avoidance. Such deficits are frequently interpreted as drug-induced amnesia. However, these deficits could also result from a learning im...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245247
更新日期:1995-03-01 00:00:00