Abstract:
:We studied anti-ischemic activity of n-tyrozol under conditions of repeated transient myocardial ischemia in rats caused by repeated (5×3 min) occlusion of the left coronary artery. n-Tyrozol administered intraperitoneally in a dose of 20 mg/kg daily over 4 days before the ischemia modeling (the last injection 15 min prior to the start of the experiment) produced a clear-cut anti-ischemic effect: it reduced ST elevation and promoted more complete recovery of ECG during reperfusion. During reperfusion periods, n-tyrozol significantly decreased the risk of ventricular fibrillation and shortened the duration of tachyarrhythmia episodes (ventricular tachycardia and fibrillation).
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Plotnikov MB,Chernysheva GA,Smol'yakova VI,Plotnikova TM,Sysolyatin SV,Kryukov YAdoi
10.1007/s10517-018-4228-1subject
Has Abstractpub_date
2018-09-01 00:00:00pages
625-628issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-018-4228-1journal_volume
165pub_type
杂志文章abstract::Tenoten is a new anxiolytic and antidepressant based on antibodies to brain-specific protein S-100B. Experimental studies demonstrated the effect of tenoten on mechanisms of neuronal plasticity and manifestations of higher nervous activity. Tenoten is clinically comparable with amitryptiline, sertraline, and phenazepa...
journal_title:Bulletin of experimental biology and medicine
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abstract::Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type ...
journal_title:Bulletin of experimental biology and medicine
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doi:10.1007/s10517-007-0346-x
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abstract::The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased...
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doi:10.1007/s10517-005-0047-2
更新日期:2004-10-01 00:00:00
abstract::JAK/STAT signaling pathway was examined comparatively during realization of growth potential of mesenchymal progenitor cells stimulated with diterpene alkaloid songorine or fibroblast growth factor. The stimulating role of JAKs and STAT3 on the mitotic activity and differentiation of progenitor cells cultured with son...
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pub_type: 杂志文章
doi:10.1007/s10517-018-4237-0
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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