Abstract:
:The possibility of using hyaluronidase for the regulation of the state of different pools of mesenchymal precursors in vivo was demonstrated. The reaction of mesenchymal precursor cells depended on the dose of the enzyme. Administration of hyaluronidase in a dose of 20 U/mouse increased the content of stromal precursors and mesenchymal stem cells in the bone marrow and promotes mobilization of precursor cells induced by granulocyte CSF. Administration of high dose of hyaluronidase (100 U/mouse) reduced the content of mesenchymal precursors in hemopoietic tissue and abolished granulocyte CSF-induced mobilization of mesenchymal precursor cells of different maturity.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Goldberg ED,Dygai AM,Zyuz'kov GN,Zhdanov VV,Simanina EV,Gur'yantseva LAdoi
10.1007/s10517-007-0176-xsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
548-51issue
4eissn
0007-4888issn
1573-8221journal_volume
143pub_type
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