Abstract:
:We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5-40 μM) and particle size (5-30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation inductor ADP in all applied doses (1.6, 2.0, and 5.0 μM). Nanoparticles with a diameter of >60 nm inhibited platelet aggregation. These findings and published data confirm the biological safety of gold nanoparticles for targeted delivery of drugs and phototherapy.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Aseychev AV,Azizova OA,Beckman EM,Dudnik LB,Sergienko VIdoi
10.1007/s10517-013-2226-xsubject
Has Abstractpub_date
2013-09-01 00:00:00pages
685-8issue
5eissn
0007-4888issn
1573-8221journal_volume
155pub_type
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