Abstract:
:The content of urokinase- and tissue-type plasminogen activators and plasminogen activator inhibitor PAI-1 in the cytosol of primary and metastatic melanomas and benign skin pigment neoplasms was estimated by enzyme immunoassay. It was shown that local growth and invasion of melanomas are related to suppressed expression of tissue plasminogen activator. The content of urokinase plasminogen activator increases in patients with distant metastases and large thickness of the primary tumor.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Gershtein ES,Medvedeva SV,Babkina IV,Kushlinskii NE,Trapeznikov NNdoi
10.1023/a:1012532412896subject
Has Abstractpub_date
2001-07-01 00:00:00pages
670-4issue
1eissn
0007-4888issn
1573-8221journal_volume
132pub_type
杂志文章abstract::Plasma concentration of immune complexes and antibodies to serotonin and dopamine were higher in patients with Alzheimer's disease compared to mentally healthy volunteers of the same age. Plasma concentrations of antibodies to serotonin and dopamine decreased with the increase in the duration of this disease. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1020692218416
更新日期:2002-07-01 00:00:00
abstract::Behavioral responses of 90-day-old male offspring from female Wistar rats exposed to restraint stress during the last week of pregnancy were studied in the formalin test. Specific biphasic behavioral response characterized acute (phase 1) and persistent tonic pain (phase 2). The intensity of nociceptive responses (eva...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1015530318241
更新日期:2002-02-01 00:00:00
abstract::Chinese hamster cells in culture were blocked in prometaphase by the addition of chloral hydrate. After 2 h the chloral hydrate was removed and the ultrastructural changes in the kinetochore studied during recovery of mitosis. The kinetochore in the blocked cells is a disc measuring 300-350 nm in diameter and 30-35 nm...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/BF00799327
更新日期:1975-01-01 00:00:00
abstract::Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF-/- mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantita...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04991-7
更新日期:2020-10-01 00:00:00
abstract::We developed a cytochrome P450 substrate-inhibitor panel for preclinical in vitro evaluation of drugs in a 3D histotypical microfluidic cell model of human liver (liver-on-a-chip technology). The concentrations of substrates and inhibitors were optimized to ensure reliable detection of the principal metabolites by HPL...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-016-3567-z
更新日期:2016-11-01 00:00:00
abstract::We performed a complex morphological analysis of atherosclerotic plaques obtained from 68 men with coronary atherosclerosis during coronary bypass surgery with endarterectomy. The expression of MMP-2 and MMP-9, collagen IV, CD31, CD34, factor VIII, and of smooth muscle cell actin was measured in the samples by morphom...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-018-4268-6
更新日期:2018-10-01 00:00:00
abstract::Effects of pentobarbital on spectral characteristics and phase ratios of wave oscillations of the cardiac contraction period (RR interval) and time of atrioventricular conduction (AV interval) were studied in experiments of cats. Pentobarbital moderately reduced the mean values of both intervals and significantly redu...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0151-y
更新日期:2006-03-01 00:00:00
abstract::The absence of negative effects of anoceptin on the liver tissue and detoxifying function was proven experimentally in vitro and in vivo. It was proven for the first time that comenic acid (anoceptin active substance) in concentrations of 10(-4)-10(-12) does not modulate the growth of liver explants from 10-12-day chi...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-010-1066-1
更新日期:2010-12-01 00:00:00
abstract::Histaminergic contractile reactions of smooth muscles in rabbit lobar pulmonary arteries were studied using in vitro mechanographic technique. Histamine via activation of H-receptors induced a dose-dependent constriction of smooth muscle segments, while endothelium inhibited histamine-induced contractile reactions. Hi...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1013013524747
更新日期:2001-08-01 00:00:00
abstract::Activation of free radical oxidation and inhibition of antioxidant activity in mouse myocardium after long-term dipyridamole treatment were demonstrated using chemiluminescent techniques. At the same time, dipyridamole 10-fold inhibited free radical oxidation and slightly increased antioxidant activity in the plasma. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1012342300406
更新日期:2001-06-01 00:00:00
abstract::The third author's name should read: V. V. Matchkov. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10517-019-04487-z
更新日期:2019-05-01 00:00:00
abstract::Experiments on rat model of toxic liver damage (CCl4, subcutaneously) have demonstrated that selenium nanopreparation on arabinogalactan matrix and partially arabinogalactan alone prevented the development of oxidative stress assessed by the balance of LPO and antioxidant defense processes. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-015-2928-3
更新日期:2015-06-01 00:00:00
abstract::The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose of the initial substance and 1.3% its metabolites were eliminated with excrements within 24 h after administration via both routes 0.23%. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-012-1746-0
更新日期:2012-08-01 00:00:00
abstract::The epileptogenic effects of applications of NMDA and kainic acid solutions to the frontal cortex were attenuated in rats receiving ketogenic diet (80% lipids, 3.3% carbohydrates, and 16.7% proteins) during 4 weeks. Spike latency increased, the power of focal epileptic activity decreased, and focus lifetime was shorte...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-013-1976-9
更新日期:2013-02-01 00:00:00
abstract::The concentrations of the key factors of molecular pathogenesis of prehypertension (angiotensin II, HLDF24, S100b, endothelin, autoantibodies to these molecules, and VEGF) were analyzed in subjects with optimal BP (<120/80 mm Hg) and prehypertension (120-139/80-89 mm Hg). Comparative and correlation analysis of the le...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04696-x
更新日期:2020-01-01 00:00:00
abstract::The cell composition of leukocyte infiltrates in the endometrium, myometrium, and vaginal walls was studied in Wistar rats with modeled chronic endomyometritis after administration of IFNγ (0.1 μg/100 g body weight) in different daily regimens (10.00 or 20.00). Morning injections of this cytokine ameliorated inflammat...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04921-7
更新日期:2020-08-01 00:00:00
abstract::Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal lobes of both hemispheres was by 36% higher than in other cortical areas, while total antioxid...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-018-4256-x
更新日期:2018-10-01 00:00:00
abstract::In acute experiments on cats neural inotropic and lusitropic reactions of the heart to enhancement of pre- and afterload were assessed by changes in contractility and relaxation indices, which were preliminary chosen for their maximum specificity and sensitivity. The control cardiac responses to increased pre- and aft...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1024644310907
更新日期:2003-04-01 00:00:00
abstract::Monoamine metabolism in the hypothalamus and striatum of BALB/c and C57Bl/6 mice (intact and stressed in the open field test) was studied using single- and multidimensional statistical methods. It is suggested that the revealed difference in neurotransmitter metabolism is associated with genetically controlled behavio...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/BF02439811
更新日期:2000-05-01 00:00:00
abstract::Ultrastructural characteristics of cell populations in the gastric tube mucosa were studied after plastic surgery for benign esophageal disease. The foveolar epithelium mainly consisted of secretory active mucocytes with small changes in cytoplasmic organelles. Functionally immature parietal cells and gland cells in t...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-011-1175-5
更新日期:2011-02-01 00:00:00
abstract::We studied the effects of a concentrate of metabolites of Trichoderma harzianum Rifai F-180, an active producer of L-lysine-α-oxidase, and homogenous enzyme on a highly virulent bacteria Erwinia amylovora. The producer of antitumor and antiviral Trichoderma enzyme L-lysine-α-oxidase was cultured on a processing system...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-017-3901-0
更新日期:2017-10-01 00:00:00
abstract::We studied the effect of sodium hydrosulfite (NaHS), a donor of hydrogen sulfide (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the prep...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2551-8
更新日期:2014-07-01 00:00:00
abstract::We studied the effect of continuous vibration and treatment with licorice root (Glycyrrhiza glabra L.) on peripheral blood red cells in rabbits. Active substances of licorice root accelerated metabolism in cells of the bone marrow erythroid stem, enhanced compensatory reserve of the organism, and increased animal's re...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0444-6
更新日期:2005-08-01 00:00:00
abstract::The dynamics of blood concentrations of reactive oxygen species and LPO products in patients with thermal injuries of different severity was studied. Monitoring of these parameters by chemiluminescent and spectrophotometric techniques helps to predict the course of burn shock and prevent complications. Erysod (0.004% ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1022638213724
更新日期:2002-11-01 00:00:00
abstract::Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by mar...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-017-3782-2
更新日期:2017-06-01 00:00:00
abstract::Single intramuscular injection of selective of NMDA receptor blocker memantine in the maximum dose of 20 mg/kg prevented the development of acute generalized tonic-clonic kainate seizures in 60% rats, but did not alleviate clonic kainate seizures and prevented chronic kainate lethality in only 30% rats. Intramuscular ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2480-6
更新日期:2014-05-01 00:00:00
abstract::Fifty-six primary neuroendocrine lung tumors were examined morphologically and histologically and their apoptosis level was determined. Malignant carcinomas were characterized by increased apoptotic index and enhanced expression ofBcl-2, Bak, p53, and Ki-67 compared to typical carcinoid. However, apoptosis in these tu...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/BF02682109
更新日期:2000-07-01 00:00:00
abstract::Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/b:bebm.0000010969.76881.87
更新日期:2003-10-01 00:00:00
abstract::No appreciable disorders of cellular immunity were detected in patients with glandular cystic endometrial hyperplasia. Atypical endometrial hyperplasia was associated with quantitative changes in T lymphocytes and their subpopulations, decreased level of lymphocytes carrying activation antigens, and increased count of...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1023410332246
更新日期:2003-01-01 00:00:00
abstract::We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-012-1736-2
更新日期:2012-08-01 00:00:00