Abstract：
:Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal lobes of both hemispheres was by 36% higher than in other cortical areas, while total antioxidant activity was by 25% higher than in other areas. During ischemia, changes in oxidative status were localized only in the ischemic focus and penumbra zone and did not involve other cortical areas. We demonstrated for the first time a neuroprotective effect of therapeutic administration of carnosine in low doses (50 mg/kg) on parameters of the oxidative status under conditions of focal ischemia comparable to its effect of high doses (500 mg/kg) as well as its local effect in the penumbra zone. A dose-dependent effect of carnosine on antioxidant activity in the penumbra zone during ischemia was also demonstrated. These findings confirm effectiveness of not only preventive carnosine administration, but also its application in the postischemic period of the stroke.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Fedorova TN,Devyatov AA,Berezhnoi DS,Stvolinskii SL,Morozova MP,Gavrilova SA,Tutelyan VAdoi
10.1007/s10517-018-4256-xsubject
Has Abstractpub_date
2018-10-01 00:00:00pages
746-750issue
6eissn
0007-4888issn
1573-8221pii
10.1007/s10517-018-4256-xjournal_volume
165pub_type
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