Abstract：
:Nadcin in a dose of 90 mg/kg administered to dogs with subacute stage of ischemia-reperfusion myocardial injury immediately after blood flow resumption normalized redox potential of cardiomyocytes and mitochondria and restored the total content of adenyl and pyridine nucleotides. The decrease in the synthesis of ATP and pyridine nucleotides and reduction of the redox potential of the energy supply system were inversely related to the increase in poly-(ADP-ribose)-polymerase activity in the ischemic area and nonischemic region. Nadcin abolished the increase in poly-(ADP-ribose)-polymerase activity in the ischemic area of the right ventricle, nonischemic region, and ischemic area of the left ventricle (by 2.4, 2.9, and 1.52 times, respectively) and normalized bioenergetic activity of cardiomyocytes during ischemia-reperfusion myocardial injury.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sukoyan GV,Kavadze IKdoi
10.1007/s10517-008-0268-2subject
Has Abstractpub_date
2008-09-01 00:00:00pages
321-4issue
3eissn
0007-4888issn
1573-8221pii
doijournal_volume
146pub_type
杂志文章abstract：:The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose of the initial substance and 1.3% its metabolites were eliminated with excrements within 24 h after administration via both routes 0.23%. ...
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