Abstract:
:The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose of the initial substance and 1.3% its metabolites were eliminated with excrements within 24 h after administration via both routes 0.23%.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Litvin EA,Bastrygin DV,Kolyvanov GB,Alekseyev KV,Zherdev VPdoi
10.1007/s10517-012-1746-0subject
Has Abstractpub_date
2012-08-01 00:00:00pages
481-2issue
4eissn
0007-4888issn
1573-8221journal_volume
153pub_type
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abstract::Experiments on rats showed that blockade of hyperpolarization-activated currents moderates tachycardia induced by beta-adrenoceptor agonist isoproterenol and potentiates the increase in stroke volume produced by this agonist. Electrical stimulation of the vagus nerve against the background of isoproterenol treatment a...
journal_title:Bulletin of experimental biology and medicine
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abstract::We studied high-resolution (1)H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the first episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH(2) protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of CH(2...
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abstract::Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did ...
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abstract::Local application of ointment with Bacillus spp. strain MG8 (15,000-20,000 living bacterial cells), isolated from permafrost specimens, on the skin wound of about 60 mm(2) stimulated the reparation processes in experimental mice. A possible mechanism stimulating the regeneration of the damaged tissues under the effect...
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doi:10.1007/s10517-015-2789-9
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abstract::We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous...
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abstract::Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while chan...
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abstract::The cytokine status (IFN, IL, etc.) of different monkey species (M. mulatta, P. hamadryas, C. aethiops) was studied. The interferon status is determined by the following parameters: IFN content in circulating blood and production of IFN-alpha and IFN-gamma by lymphocytes after appropriate in vitro induction. The inter...
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doi:10.1007/s10517-009-0708-7
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abstract::We studied the effects of optical (dd-, ll-, dl-, and ld-dipeptides with alpha-bond, EW) structural isomers and cyclic (dd-, ll-, dl-, and ld-dipeptides with gamma-bond, iEW) analogs of Glu-Trp synthetic dipeptide on the population of normal hemopoietic stem cells. Dipeptides containing lGlu (lGlu-lTrp, lGlu-dTrp) inj...
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abstract::The content of urokinase- and tissue-type plasminogen activators and plasminogen activator inhibitor PAI-1 in the cytosol of primary and metastatic melanomas and benign skin pigment neoplasms was estimated by enzyme immunoassay. It was shown that local growth and invasion of melanomas are related to suppressed express...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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abstract::Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormon...
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abstract::The development of dissociated cells from rat embryonic spinal ganglion after transplantation to damaged nerve of adult animals was studied using immunohistochemical differentiation markers of neural and glial cells. The cell suspension obtained after dissociation of rat embryonic spinal ganglia (embryonic day 15) was...
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doi:10.1007/s10517-014-2633-7
更新日期:2014-09-01 00:00:00
abstract::We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress). Stress exposure of animals for 30 days was followed by a decrease in the relati...
journal_title:Bulletin of experimental biology and medicine
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doi:10.1007/s10517-014-2343-1
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10517-005-0420-1
更新日期:2005-07-01 00:00:00
abstract::Correlation between changes in activity of intracellular Ca(2+)-activated proteinases and cholesterol content in mussels in response to changes in habitat saltiness was detected in mollusks from littoral and sublittoral White sea zones. Calpain activity in mussels decreased in low water saltiness and increased in high...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0518-5
更新日期:2005-10-01 00:00:00
abstract::Integral activity of neutral deoxyribonucleases in the plasma and urine or donors, patients with benign prostatic hyperplasia, and patients with stomach and prostatic cancer was studied by IFA based on hydrolysis of DNA fragment modified with haptene molecules. In donors plasma deoxyribonuclease activity was 0.16+/-0....
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pub_type: 杂志文章
doi:10.1007/s10517-008-0213-4
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abstract::The effect of epithalamin on circadian rhythms of thymic serum factor titers and melatonin concentrations in the blood of elderly people was studied. Course treatment with epithalamin modulated the rhythm of the thymic endocrine function. The increase in the titer of thymic serum factor at night coincided with the inc...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-017-3739-5
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pub_type: 杂志文章
doi:10.1023/a:1020633427502
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abstract::The relationships between open field behavior, initial nociceptive thresholds, and immunoreactivity assessed according to the development of hyperthermia triggered by LPS pyrogenal were examined in Wistar rats. Behaviorally active animals demonstrated higher nociceptive thresholds and greater immunoreactivity in compa...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-011-1478-6
更新日期:2011-12-01 00:00:00
abstract::The primary culture of rat cerebellar neurons was used to study protein kinase C activity, intracellular variations in calcium concentration ([Ca(2+)]i), changes in the mitochondrial potential, and neuronal death during hyperstimulation of glutamate receptors and after 24-h incubation with phorbol ester. Prolonged exp...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-008-0159-6
更新日期:2008-05-01 00:00:00
abstract::Treatment with a combination of artrofoon and anaferon significantly reduced clinical and laboratory parameters of rheumatoid inflammation and significantly decreased the content of antiinflammatory cytokines in the blood. These findings attest to antiinflammatory and immunomodulating effects of these preparations. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10517-010-0744-3
更新日期:2009-09-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-008-0248-6
更新日期:2008-08-01 00:00:00
abstract::Comparative analysis of proteoglycans in the control and tumor tissue of human mammary gland revealed disorders in the biosynthesis of dermatan sulfate proteoglycans in tumor cells. Using the methods of reverse transcription-PCR and Western blotting for the analysis of decorin expression we showed that these disorders...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-007-0326-1
更新日期:2007-09-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-018-4311-7
更新日期:2018-12-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04878-7
更新日期:2020-07-01 00:00:00
abstract::We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locom...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-011-1256-5
更新日期:2011-05-01 00:00:00
abstract::Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the develop...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-019-04424-0
更新日期:2019-04-01 00:00:00