Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice.

abstract：:A test system developed by the authors was used to measure serum concentrations of soluble Fas in patients with malignant and benign tumors of different location and morphology. Relationships between soluble Fas levels and the main clinical and morphological characteristics of cancer were evaluated. It is proven that ...

journal_title：Bulletin of experimental biology and medicine

authors： Abbasova SG,Vysotskii MM,Ovchinnikova LK,Obusheva MN,Digaeva MA,Britvin TA,Bahoeva KA,Karabekova ZK,Kazantzeva IA,Mamedov UR,Manuchin IB,Davidov MI

更新日期：2009-10-01 00:00:00

abstract：:Enzyme immunoassay of the serum neurospecific antigens (gliofibrillar acid protein and neurospecific enolase) was used for evaluation of the resistance of the blood-brain barrier in Wistar rats with perinatal hypoxia and ischemia of the CNS. Perinatal hypoxia and ischemia of the CNS was modeled by two methods: ligatio...

journal_title：Bulletin of experimental biology and medicine

authors： Chekhonin VP,Lebedev SV,Dmitrieva TB,Blinov DV,Gurina OI,Semenova AV,Volodin NN

更新日期：2003-09-01 00:00:00

abstract：:The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substa...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov IF,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:Integral activity of neutral deoxyribonucleases in the plasma and urine or donors, patients with benign prostatic hyperplasia, and patients with stomach and prostatic cancer was studied by IFA based on hydrolysis of DNA fragment modified with haptene molecules. In donors plasma deoxyribonuclease activity was 0.16+/-0....

journal_title：Bulletin of experimental biology and medicine

authors： Tamkovich SN,Cherepanova AV,Bryzgunova OE,Kolesnikova EV,Permyakova VI,Vlassov VV,Laktionov PP

更新日期：2008-07-01 00:00:00

abstract：:During left-ventricular myocardial ischemia, the decrease in the venous return is determined by reduction of cardiac output, which results from heart rate deceleration and decrease in left-ventricular stroke volume. The latter is related to a decrease in myocardial contractility and blood storage in the pulmonary circ...

journal_title：Bulletin of experimental biology and medicine

authors： Evlakhov VI,Poyassov IZ

更新日期：2012-02-01 00:00:00

abstract：:Immunization of mice with synthetic peptide fragments of conservative sites of meningococcal outer membrane proteins led to defense formation against infection with virulent serogroup A and B Meningococci. The role of cellular immunity in the formation of defense against meningococcal infection after immunization with...

journal_title：Bulletin of experimental biology and medicine

authors： Chibiskova OV,Kotel'nikova OV,Nesmeyanov VA,Alliluev AP,Vol'pina OM,Koroev DO,Filatova MP

更新日期：2007-06-01 00:00:00

abstract：:Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type ...

journal_title：Bulletin of experimental biology and medicine

authors： Gaenko GP,Khaidukov SV,Molotkovskii YG

更新日期：2004-01-01 00:00:00

abstract：:Experiments on rats showed that the lymphoprotective effect of Perftoran manifests in stimulation of contractile activity of myocytes in the wall and valve cusps of lymphatic microvessels, which in turn activates the pump and capacitive functions of the lymphatic system and improves central lymph outflow. These change...

journal_title：Bulletin of experimental biology and medicine

authors： Mukhutdinova FI,Khafiz'janova RKh,Triandafilov KA,Mukhutdinov DA

更新日期：2010-11-01 00:00:00

abstract：:Here we review the mechanisms underlying systemic regulation of the genome in brain nerve cells. Expression of early and late behavioral genes is regulated by systemic processes in dominant functional systems. The main elements of this molecular and genetic cascade are similar during learning and development. ...

journal_title：Bulletin of experimental biology and medicine

authors： Anokhin KV,Sudakov KV

更新日期：2003-02-01 00:00:00

abstract：:Blood coagulation was enhanced and all factors (total, enzyme, and non-enzyme) of the fibrinolytic system were suppressed in rats in 60 min after forced swimming test. Argininecontaining tetrapeptide glyproline Arg-Pro-Gly-Pro administered prior to this test activated fibrinolysis and prevented hypercoagulation. Admin...

journal_title：Bulletin of experimental biology and medicine

authors： Grigor'eva ME,Lyapina LA

更新日期：2017-01-01 00:00:00

abstract：:Applications of cold and warm activated cellular immunity and orientation and exploratory behavior in mice. Application of cold increased the number of turns to the left in the open field, muscle force, and activity of the food instinct, and caused an increase in the total count of peripheral blood leukocytes. Warm ap...

journal_title：Bulletin of experimental biology and medicine

authors： Kalyonova LF,Novikova MA

更新日期：2013-04-01 00:00:00

abstract：:Inductors of the monooxygenase system benzonal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by a-naphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metaboli...

journal_title：Bulletin of experimental biology and medicine

authors： Saratikov AS,Novozheeva TP,Akhmedzhanov RR

更新日期：2002-09-01 00:00:00

abstract：:Taftsin, an endogenous peptide immunostimulator, exhibits also high antiulcer activity. In a dose of 0.6 micromol/kg Taftsin decreases the area of ulcerative lesions in albino rats on various models of ulceration. ...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov TS,Samonina GE

更新日期：2004-08-01 00:00:00

abstract：:We studied morphological changes in rat abdominal aorta and vena cava inferior induced by endovascular microwave destruction. This treatment induced thrombosis and necrosis of the vascular walls, but fibrous framework was not completely destroyed. Then we observed irreversible changes in vessels: obliteration, atrophy...

journal_title：Bulletin of experimental biology and medicine

authors： Denisov-Nikol'skii YI,Shafranov VV,Borkhunova EN,Doktorov AA,Mikhaleva LM,Mikhalev AP

更新日期：2002-07-01 00:00:00

abstract：:We demonstrated the influence of short peptides on the expression of signaling molecules in organotypic culture of the pineal gland from 3-month-old rats. Peptides Ala-Glu-Asp-Gly and Lys-Glu-Asp stimulate the expression of proliferative protein Ki-67 in pineal gland culture. These peptides as well as Glu-Asp-Arg and ...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Linkova NS,Chalisova NI,Dudkov AV,Koncevaya EA

更新日期：2011-11-01 00:00:00

abstract：:We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of pancreatic β cells, and insulin system in the liver of rats with cafeteria diet-induced metabolic syndrome. The therapy reduced body weight and blood levels of insul...

journal_title：Bulletin of experimental biology and medicine

authors： Derkach KV,Ivantsov AO,Chistyakova OV,Sukhov IB,Buzanakov DM,Kulikova AA,Shpakov AO

更新日期：2017-06-01 00:00:00

abstract：:We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous...

journal_title：Bulletin of experimental biology and medicine

authors： Diatroptova MA,Ponomarenko EA,Diatroptov ME

更新日期：2020-09-01 00:00:00

abstract：:We studied the effect of interleukin-1beta on the behavior of rats with different individual typological characteristics during mild stress in the open-field test. Intraperitoneal injection of interleukin-1beta (5 microg/kg, 108 U/mg) was followed by a decrease in orientation and exploratory activity of passive and, p...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Koplik EV,Simbirtsev AS,Kalinichenko LS

更新日期：2009-11-01 00:00:00

abstract：:We compared the effect of xymedon (100 mg/kg) and Mexidol (50 mg/kg) on morphometric parameters of erythrocytes and oxygen-transporting function of hemoglobin in rats with Walker-256 carcinoma treated with docetaxel (15 mg/kg once intraperitoneally on day 11 after tumor cells transplantation). Xymedon and Mexidol were...

journal_title：Bulletin of experimental biology and medicine

authors： Siprov AV,Solovyova MA

更新日期：2017-11-01 00:00:00

abstract：:Fragments of extracellular DNA are permanently released into the blood flow due to cell apoptosis and possible de novo DNA synthesis. To find out whether extracellular DNA can affect the synthesis of nitric oxide (NO), one of key vascular tone regulators, we studied in vitro effects of three artificial DNA probes with...

journal_title：Bulletin of experimental biology and medicine

authors： Efremova LV,Alekseeva AY,Konkova MS,Kostyuk SV,Ershova ES,Smirnova TD,Konorova IL,Veiko NN

更新日期：2010-08-01 00:00:00

abstract：:The mechanisms of therapeutic resistance of human glioblastoma multiforme are analyzed. The authors make an attempt at systematization and scientific theoretical validation of new approaches to creation of biomedical cellular preparations, based on the oncoproteomic technologies, for personified therapy of the glial t...

journal_title：Bulletin of experimental biology and medicine

authors： Bryukhovetskii IS,Bryukhovetskii AS,Khotimchenko YS

更新日期：2015-04-01 00:00:00

abstract：:Groups of microRNA genes, methylation of which is associated with the initial (I-II) stages of breast cancer, are determined, and new markers and marker systems for the disease diagnosis were created on the basis of these data. A total of 14 genes in which methylation was associated with breast cancer were identified ...

journal_title：Bulletin of experimental biology and medicine

authors： Braga EA,Filippova EA,Loginov VI,Pronina IV,Burdennyi AM,Kazubskaya TP,Fridman MV,Khodyrev DS,Kushlinskii NE

更新日期：2019-12-01 00:00:00

abstract：:The efficiency of ascorbate and alpha-tocopherol as stabilizers of beta-carotene, which is widely used in complex therapy and prevention of some diseases accompanied by oxidative stress, was studied. The latency of induced beta-carotene oxidation linearly depends on ascorbate concentration, while steady-state rate non...

journal_title：Bulletin of experimental biology and medicine

authors： Kozachenko AI,Gurevich SM,Nagler LG

更新日期：2000-07-01 00:00:00

abstract：:Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (0.1 ml, 1 M) to the...

journal_title：Bulletin of experimental biology and medicine

authors： Podoprigora GI,Nartsissov YR

更新日期：2009-03-01 00:00:00

abstract：:The effects of unilateral cortical spreading depression on the resistance to acute hypoxia with hypercapnia were studied in male SHR mice. The life-span of mice with active right hemisphere was significantly longer than that of intact, but not of sham-operated (active control) animals. Mice with active left hemisphere...

journal_title：Bulletin of experimental biology and medicine

authors： Marysheva VV,Mikheev VV,Shabanov PD

更新日期：2011-07-01 00:00:00

abstract：:We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produ...

journal_title：Bulletin of experimental biology and medicine

authors： Golubeva MG,Grigoreva ME,Smirnova MP

更新日期：2005-08-01 00:00:00

abstract：:The formation of an ischemic focus in the myocardium is paralleled by autoimmune processes involving immunoglobulins with abnormal thermal solubility, cryoglobulins. Serum levels of cryoglobulins and their complexes were measured in 25 patients with Q-forming myocardial infarction on days 1, 2, 3, 7, and 14 of the dis...

journal_title：Bulletin of experimental biology and medicine

authors： Konstantinova NA,Yeremin II,Konstantinova EV,Karandashov EN,Shostak NA

更新日期：2011-02-01 00:00:00

abstract：:The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment. ...

journal_title：Bulletin of experimental biology and medicine

authors： Fadyukova OE,Kadi A,Bai O,Andzhusheva GM,Koshelev VB

更新日期：2005-04-01 00:00:00

abstract：:The qualitative and quantitative differences in lipids composition were found in chromatin fractions differing by attachment to the nuclear matrix and transcriptional activity. During liver regeneration after partial hepatectomy Changes in the lipid spectrum of chromatin fractions in G1- and S-phases are associated wi...

journal_title：Bulletin of experimental biology and medicine

authors： Trofimov VA,Dudko AA

更新日期：2006-01-01 00:00:00

abstract：:Characteristics of distribution of cholinergic and adrenoceptor structures along the sinoatrial node artery in rat heart were evaluated by autoradiography on semithin sections by determining the density of (3)H-dihydroalprenolol and (3)H-quinuclidinyl benzilate binding sites. The relative density of binding sites for ...

journal_title：Bulletin of experimental biology and medicine

authors： Sutyagin PV,Kalinina EE,Pylaev AS

更新日期：2005-07-01 00:00:00