Myogenesis in hemopoietic tissue mesenchymal stem cell culture.


:The myogenic differentiation capacity of prenatal mesenchymal stem cells from the main sites of hemopoiesis (bone marrow, thymus, liver, and spleen) was studied. Myogenesis was observed in all studied cell cultures except splenic mesenchymal stem cells. Differentiating cells from the thymus, bone marrow, and liver were positively stained for skeletal muscle markers (myogenin and MyoD). Autonomously contracting structures positively stained for cardiotroponin I and slow muscle myosin, were detected in the same cultures. Our experiments revealed differences in differentiation of mesenchymal stem cells from hemopoietic organs depending on the source of cells.


Bull Exp Biol Med


Gornostaeva SN,Rzhaninova AA,Gol'dstein DV




Has Abstract


2006-04-01 00:00:00












  • Extracellular DNA affects NO content in human endothelial cells.

    abstract::Fragments of extracellular DNA are permanently released into the blood flow due to cell apoptosis and possible de novo DNA synthesis. To find out whether extracellular DNA can affect the synthesis of nitric oxide (NO), one of key vascular tone regulators, we studied in vitro effects of three artificial DNA probes with...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Efremova LV,Alekseeva AY,Konkova MS,Kostyuk SV,Ershova ES,Smirnova TD,Konorova IL,Veiko NN

    更新日期:2010-08-01 00:00:00

  • The Role of Inducible NOS2 Gene Polymorphism in the Development of Essential Arterial Hypertension.

    abstract::The risk of essential arterial hypertension was assessed in carriers of the NOS2 gene variants (rs1800482 (-954G>C), rs3730017 (C>T)). In subjects carrying C allele (rs1800482), the risk for essential arterial hypertension developing was higher by 1.7 times (OR=1.712, 95%CI 1.07-2.74), while the presence of T-allele (...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Topchieva LV,Balan OV,Korneeva VA,Malysheva IE

    更新日期:2019-11-01 00:00:00

  • Blood flow in the testes and epididymides of male rats with experimental blockade of testicular veins.

    abstract::Blood flow in reproductive organs was studied during experimental cessation of blood outflow in the testicular vein. This pathological state was accompanied by disturbances of the complex pathogenesis. The major component was autoregulatory focal ischemia, which resulted from the venoarterial response to venous hypert...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Artifeksov SB,Artyukhin AA

    更新日期:2007-06-01 00:00:00

  • Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins.

    abstract::Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by i...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Khavinson VKh,Lin'kova NS,Polyakova VO,Kvetnoy IM,Benberin VV,D'yakonov MM,Titkov YS

    更新日期:2012-08-01 00:00:00

  • Rats of hypertensive ISIAH strain are resistant to the development of metabolic syndrome induced by high-fat diet.

    abstract::We studied the influence of high-fat diet on the development of metabolic syndrome in rats of hypertensive ISIAH strain and normotensive WAG strain. In contrast to ISIAH rats, high-fat diet in WAG rats led visceral obesity, glucose tolerance, and dyslipidemia. DNA-binding activity of the peroxisome proliferator-activa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Dushkin MI,Khrapova MV,Kovshik GG,Chasovskikh MI,Selyatitskaya VG,Palchikova NA

    更新日期:2014-03-01 00:00:00

  • Infradian Rhythm in Proliferative Activity of a Culture of Embryonic Fibroblast-Like Cells from C57BL/6 Mice.

    abstract::We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Diatroptova MA,Ponomarenko EA,Diatroptov ME

    更新日期:2020-09-01 00:00:00

  • Xenotransplantation of embryonic precursors of human myogenesis for the correction of dystrophinopathy in mice with hereditary muscular dystrophy.

    abstract::Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Yarygin VN,Sukhikh GT,Sitnikov VF,Stenina MA,Kuznetsov AB,Poltavtseva RA,Krivov LI,Voevodin DA,Savchuk VI,Revishchin AV,Korochkin LI,Aleksandrova MA

    更新日期:2003-07-01 00:00:00

  • Fluorescent granular cells of the thymus can be identified as dendritic macrophages.

    abstract::Fluorescent granular cells of the thymus lobule containing neurotransmitter monoamines express Ia antigen and S-100 protein, which attests to their macrophage origin; positive staining with aldehyde fuchsin points to secretion of peptide hormones by these cells. These facts and the absence of phagocytic activity allow...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Gordon DS,Sergeeva VE,Smorodchenko AT,Kirillov NA,Petrova TL,Olangin OI,Spirin IV

    更新日期:2001-07-01 00:00:00

  • Effects of substance S-1 on rats with impaired hearing.

    abstract::Intraperitoneal administration of substance S-1 to male Wistar rats with impaired hearing markedly increased hearing acuity. Substance S-1 had no negative effects on hearing in intact animals. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Shestakova EV

    更新日期:2002-01-01 00:00:00

  • Vitamin B-complex initiates growth and development of human embryonic brain cells in vitro.

    abstract::We studied a combined effect of subcomponents of vitamin B complex on the growth, development, and death of human embryonic brain-derived cells (E90) cultured using a modified method of Matson. Cell death was detected by trypan blue staining. According to our results, vitamin B-complex in low-doses promote the develop...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Danielyan KE,Abramyan RA,Galoyan AA,Kevorkian GA

    更新日期:2011-09-01 00:00:00

  • Morphofunctional evaluation of the effect of collagen-1-based dressing on skin regeneration after burn trauma in mice of two genetic strains.

    abstract::Morphofunctional evaluation of the effect of biological dressing with collagen-1 on healing of 3A degree burn wound in outbred and mutant Hr(hr)/Hr(hr)(hairless) mice was carried out by the histological method and optic radioautography. A pronounced stimulatory effect of the dressing on skin regeneration in mice was d...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Kolokolchikova EG,Zhirkova EA,Golovatenko-Abramov PK,Platonov ES,Botcharova VS,Khvatov VB

    更新日期:2010-07-01 00:00:00

  • Effect of Bioritm-E phytococktail and experimental medicinal drug from spurdog liver Skvaakan on microcirculation, platelet aggregation, and thromboresistance of vascular wall in rats.

    abstract::The study compared the effects of phytococktail Bioritm-E (a multicomponent phytoadaptogen) and experimental preparation Skvaakan from the liver of Black Sea spurdog on systemic homeostasis, microcirculation, and blood lipid profile in 15 days of their daily administration. Skvaakan enhanced the platelet activity prod...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Datieva FS,Khetagurova LG

    更新日期:2012-12-01 00:00:00

  • Main regularities of mutual location of different pacemaker cells in the rat heart sinoatrial node.

    abstract::The distribution of pacemaker cells and atrial working cardiomyocytes in the anterior right atrial wall was studied using intracellular glass microelectrodes under conditions of short-term culturing. It was shown that the dominant pacemaker region and the functional tail are located in the lateral area of the central ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Sutyagin PV,Kamkin AG,Gurina OY

    更新日期:2009-09-01 00:00:00

  • Antithrombotic Protective Effects of Arg-Pro-Gly-Pro Peptide during Emotional Stress Provoked by Forced Swimming Test in Rats.

    abstract::Blood coagulation was enhanced and all factors (total, enzyme, and non-enzyme) of the fibrinolytic system were suppressed in rats in 60 min after forced swimming test. Argininecontaining tetrapeptide glyproline Arg-Pro-Gly-Pro administered prior to this test activated fibrinolysis and prevented hypercoagulation. Admin...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Grigor'eva ME,Lyapina LA

    更新日期:2017-01-01 00:00:00

  • Effect of Erysod (erythrocyte superoxide dismutase) on blood concentration of reactive oxygen species in patients with severe burns and burn shock.

    abstract::The dynamics of blood concentrations of reactive oxygen species and LPO products in patients with thermal injuries of different severity was studied. Monitoring of these parameters by chemiluminescent and spectrophotometric techniques helps to predict the course of burn shock and prevent complications. Erysod (0.004% ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Churilova IV,Zinov'ev EV,Paramonov BA,Drozdova YI,Sidel'nikov VO,Chebotarev VY

    更新日期:2002-11-01 00:00:00

  • Mathematical simulation of p53-Mdm2 protein biological system regulation.

    abstract::Digital simulation of disorders in the p53 and Mdm2 protein system, involved in repair of DNA defects and in many vital processes, including tumor formation, neurodegeneration, and aging, was carried out on the base of functional nonlinear octoparametric mathematical model. Stress situations were studied, associated w...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Voropaeva OF,Shokin YI,Nepomnyashchikh LM,Senchukova SR

    更新日期:2014-08-01 00:00:00

  • Immunostimulatory effect of gold nanoparticles conjugated with transmissible gastroenteritis virus.

    abstract::Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respirat...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Staroverov SA,Vidyasheva IV,Gabalov KP,Vasilenko OA,Laskavyi VN,Dykman LA

    更新日期:2011-08-01 00:00:00

  • Survival of rats with experimental chronic heart failure depending on pharmacodynamic and pharmacokinetic parameters of angiotensin-converting enzyme inhibitors and beta-adrenoceptor blockers.

    abstract::Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity n...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Fedorov VN,Sal'nikov EV,Sidorov AV,Bogatushin AV,Fateev MM

    更新日期:2006-01-01 00:00:00

  • Immunohistochemical Phenotypes of Stable and Unstable Occlusive Atherosclerotic Plaques in Coronary Arteries.

    abstract::We performed a complex morphological analysis of atherosclerotic plaques obtained from 68 men with coronary atherosclerosis during coronary bypass surgery with endarterectomy. The expression of MMP-2 and MMP-9, collagen IV, CD31, CD34, factor VIII, and of smooth muscle cell actin was measured in the samples by morphom...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Murashov IS,Volkov AM,Kazanskaya GM,Kliver EE,Savchenko SV,Klochkova SV,Lushnikova EL

    更新日期:2018-10-01 00:00:00

  • Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.

    abstract::Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank dem...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Rogozinskaya EY,Lyapina MG

    更新日期:2017-12-01 00:00:00

  • Effect of 2-aminoadamantane derivatives on behavior of mice in a modified light/dark test.

    abstract::The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affecte...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Avgustinovich DF,Fomina MK,Suslov EV,Tolstikova TG,Volcho KP,Salakhutdinov NF

    更新日期:2014-12-01 00:00:00

  • Experimental investigation of pharmacodynamics and pharmacokinetics of carbamazepine nanoemulsion.

    abstract::Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Prokhorov DI,Sariev AK,Abramov DA,Voronina TA,Kapitsa IG,Zhuravko AS,Shiriaeva MV,Kaplun AP,Seifulla RD

    更新日期:2014-10-01 00:00:00

  • Role of receptors to fibroblast growth factor (FGF) on mesenchymal precursor cells in the realization of regenerative effects of alkaloid songorine.

    abstract::We studied the mechanisms of regenerative (wound healing) effects of songorine associated with functional activation of mesenchymal progenitor cells. The key role of FGF receptors on these progenitor cells in the stimulation of realization of their growth potential under the effect of the alkaloid was demonstrated. Un...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Zyuz'kov GN,Chaikovskii AV,Ligacheva AA,Zhdanov VV,Udut EV,Danilets MG,Miroshnichenko LA,Simanina EV,Suslov NI,Losev EA,Trofimova ES,Povet'eva TN,Nesterova YV,Fomina TI,Minakova MY,Dygai AM

    更新日期:2014-05-01 00:00:00

  • Role of placenta in the regulation of fetal erythropoiesis.

    abstract::We studied erythropoiesis in newborn infants delivered by mothers with normal pregnancy and gestosis. The effects of placental extracts on hemopoiesis in JCR mice were also evaluated. Our results suggest that the placenta is involved in the regulation of fetal erythropoiesis. The placenta activates fetal erythropoiesi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Evseenko DA,Tsirel'nikov NI

    更新日期:2001-11-01 00:00:00

  • Adrenocortical system response to induction of inflammation with silicon dioxide in rats with alloxan-induced diabetes mellitus.

    abstract::Alloxan-induced diabetes mellitus in rats was characterized by persistent increase in blood levels of corticosterone, while chronic granulomatous inflammation induced by silicon dioxide and its combination with alloxan-induced diabetes mellitus were associated with transient increase in blood corticosterone level foll...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Kuznetsova NV,Palchikova NA,Selyatitskaya VG,Shkurupiy VA

    更新日期:2010-11-01 00:00:00

  • Quantitative assessment of neurons and neuroglia with computer morphometry.

    abstract::The morphology of neural and glial cells in different cerebral areas and in various experimental models was quantitatively studied by methods of computer morphometry combined with video image analysis systems. The following parameters were obtained: density of neurons and glial cells per 1 mm(2), number of satellite p...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Khudoerkov RM,Voronkov DN

    更新日期:2010-07-01 00:00:00

  • Evaluation of the vitamin status in nursing women by vitamin content in breast milk.

    abstract::The dependence of daily vitamin excretion with breast milk on dietary vitamin content and blood vitamin level was studied in nursing women. Breast mils vitamins were assayed in women supplied with vitamins. We identified the criteria for adequate vitamin supply in nursing women over the 1st month after labor (vitamins...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Kodentsova VM,Vrzhesinskaya OA

    更新日期:2006-03-01 00:00:00

  • Comparison of the Effect of Platinum (IV) Complexes on Spheroids and Monolayer Culture of HeLa Cells.

    abstract::We performed a comparative study of the cytotoxicity of cisplatin, JM216 complex, and aminonitroxyl platinum(IV) complexes for HeLa cells grown in monolayer and 3D culture. The growth dynamics of spheroids was studied and optimal conditions for evaluation of cytotoxicity were determined. Spheroids were less sensitive ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Trigub ММ,Filatova NV,Areshidze DА,Sen' VD,Terentiev АА

    更新日期:2020-02-01 00:00:00

  • Role of Bcl-2, Bax, and Bak in spontaneous apoptosis and proliferation in neuroendocrine lung tumors: immunohistochemical study.

    abstract::Fifty-six primary neuroendocrine lung tumors were examined morphologically and histologically and their apoptosis level was determined. Malignant carcinomas were characterized by increased apoptotic index and enhanced expression ofBcl-2, Bak, p53, and Ki-67 compared to typical carcinoid. However, apoptosis in these tu...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Pal'tsev MA,Demura SA,Kogan EA,Jaques G,Zende B

    更新日期:2000-07-01 00:00:00

  • Neuroprotective Effects of Peptides during Ischemic Preconditioning.

    abstract::Experiments on rats showed that neurospecific protein preparations reduce the severity of neurological deficit, restore the structure of individual behavior of the animals with different hypoxia tolerance, and exert antioxidant action during chronic ischemic damage to the brain unfolding during the early and late phas...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Zarubina IV,Shabanov PD

    更新日期:2016-02-01 00:00:00