Effect of Hepatitis C Virus Coinfection on the Content of CD4(+) and CD8(+) T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy.

Abstract:

:We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4(+) T cells and an increase in the count of central CD8(+) memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4(+) memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.

journal_name

Bull Exp Biol Med

authors

Korolevskaya LB,Shmagel KV,Saidakova EV,Shmagel NG,Slobodchikova SV,Chereshnev VA

doi

10.1007/s10517-016-3395-1

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

281-3

issue

2

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-016-3395-1

journal_volume

161

pub_type

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