Structural and functional changes in pulmonary macrophages and lungs of mice infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05.

Abstract:

:C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fibrosis of the interstitium. On days 6-10 after infection, fibrosis was found in the zones of postnecrotic inflammatory infiltration. The expression of lysozyme and myeloperoxidase by pulmonary macrophages was initially increased, but decreased on day 10 of the study. The number of cathepsin D-expressing macrophages was elevated up to the 10th day of examination.

journal_name

Bull Exp Biol Med

authors

Kovner AV,Anikina AG,Potapova OV,Sharkova TV,Cherdanceva LA,Shkurupy VA,Shestopalov AM

doi

10.1007/s10517-012-1683-y

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

229-32

issue

2

eissn

0007-4888

issn

1573-8221

journal_volume

153

pub_type

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